(49 nodes) Negative regulation of BMP signaling pathway network (Enhydra lutris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	LOC111145934	Von Willebrand factor C domain-containing protein 2-like. (222 aa)
	LOC111140644	Gremlin-1 isoform X1. (240 aa)
	LOC111139315	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	LOC111141989	Low-density lipoprotein receptor-related protein 2. (4705 aa)
	LOC111142142	Inner nuclear membrane protein Man1. (913 aa)
	LOC111142011	Inner nuclear membrane protein Man1-like. (353 aa)
	LOC111142519	Twisted gastrulation protein homolog 1. (223 aa)
	LOC111142744	Mothers against decapentaplegic homolog. (426 aa)
	LOC111142763	SKI family transcriptional corepressor 2. (1010 aa)
	LOC111144443	Secreted frizzled-related protein 1. (314 aa)
	LOC111144482	Secreted frizzled-related protein 1-like. (250 aa)
	LOC111142981	E3 ubiquitin-protein ligase TRIM33 isoform X1. (1127 aa)
	LOC111144968	Tumor necrosis factor-inducible gene 6 protein. (277 aa)
	LOC111145504	E3 ubiquitin-protein ligase. (728 aa)
	LOC111146116	Tyrosine-protein kinase. (1149 aa)
	LOC111145746	Homeobox protein DLX-1 isoform X1. (255 aa)
	LOC111147437	Sclerostin domain-containing protein 1. (206 aa)
	LOC111145671	Neurogenic locus notch homolog protein 1. (2562 aa)
	LOC111147356	BMP-binding endothelial regulator protein. (685 aa)
	LOC111149183	Serine protease HTRA3 isoform X2. (456 aa)
	LOC111150788	Ski-like protein. (684 aa)
	LOC111150438	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (956 aa)
	LOC111151788	Protein Tob1 isoform X1. (345 aa)
	LOC111153274	Mothers against decapentaplegic homolog. (497 aa)
	LOC111153127	LOW QUALITY PROTEIN: SKI family transcriptional corepressor 1. (954 aa)
	LOC111150923	Gremlin. (168 aa)
	LOC111151807	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	LOC111151859	Homeodomain-interacting protein kinase 2 isoform X1. (1233 aa)
	LOC111154704	Secreted frizzled-related protein 2. (294 aa)
	LOC111152226	LEM domain-containing protein 2 isoform X1. (501 aa)
	LOC111154686	Neuroblastoma suppressor of tumorigenicity 1. (175 aa)
	LOC111153957	Sortilin-related receptor isoform X1. (2326 aa)
	LOC111156587	Cerberus. (269 aa)
	LOC111154591	Ski oncogene isoform X1. (730 aa)
	LOC111157084	Brorin. (325 aa)
	LOC111158015	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	LOC111158675	Fibrillin-1. (2871 aa)
	LOC111159358	Chordin-like protein 2 isoform X1. (462 aa)
	LOC111158971	CTD small phosphatase-like protein 2. (466 aa)
	LOC111159664	Homeobox protein NANOG. (310 aa)
	LOC111158164	E3 ubiquitin-protein ligase. (748 aa)
	LOC111158419	Cysteine-rich motor neuron 1 protein. (1034 aa)
	LOC111158546	Spartin isoform X1. (671 aa)
	LOC111157540	Transmembrane protease serine 6 isoform X2; Belongs to the peptidase S1 family. (802 aa)
	LOC111158020	Sclerostin. (213 aa)
	LOC111160958	Chordin-like protein 1 isoform X1. (459 aa)
	LOC111162072	Hemojuvelin isoform X1. (427 aa)
	LOC111162593	Protein phosphatase 1A isoform X3. (403 aa)
	LOC111161797	Follistatin-related protein 3 isoform X1. (362 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111139315	LOC111142744	A0A2Y9IMK0	A0A2Y9IT89	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.957
LOC111139315	LOC111153274	A0A2Y9IMK0	A0A2Y9K338	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.753
LOC111139315	LOC111154704	A0A2Y9IMK0	A0A2Y9K9Z4	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Secreted frizzled-related protein 2.	0.453
LOC111140644	LOC111150923	A0A2Y9IMH2	A0A2Y9K3Q7	Gremlin-1 isoform X1.	Gremlin.	0.901
LOC111141989	LOC111158015	A0A2Y9IQ17	A0A2Y9KNG0	Low-density lipoprotein receptor-related protein 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.470
LOC111141989	LOC111158020	A0A2Y9IQ17	A0A2Y9L211	Low-density lipoprotein receptor-related protein 2.	Sclerostin.	0.527
LOC111142011	LOC111162593	A0A2Y9IQU1	A0A2Y9LC85	Inner nuclear membrane protein Man1-like.	Protein phosphatase 1A isoform X3.	0.466
LOC111142142	LOC111162593	A0A2Y9IQP1	A0A2Y9LC85	Inner nuclear membrane protein Man1.	Protein phosphatase 1A isoform X3.	0.466
LOC111142519	LOC111147356	A0A2Y9IRW9	A0A2Y9JMI8	Twisted gastrulation protein homolog 1.	BMP-binding endothelial regulator protein.	0.422
LOC111142519	LOC111150438	A0A2Y9IRW9	A0A2Y9JVT7	Twisted gastrulation protein homolog 1.	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	0.722
LOC111142519	LOC111158419	A0A2Y9IRW9	A0A2Y9KXT0	Twisted gastrulation protein homolog 1.	Cysteine-rich motor neuron 1 protein.	0.450
LOC111142519	LOC111159358	A0A2Y9IRW9	A0A2Y9KUQ7	Twisted gastrulation protein homolog 1.	Chordin-like protein 2 isoform X1.	0.651
LOC111142519	LOC111160958	A0A2Y9IRW9	A0A2Y9L3X8	Twisted gastrulation protein homolog 1.	Chordin-like protein 1 isoform X1.	0.424
LOC111142519	LOC111161797	A0A2Y9IRW9	A0A2Y9LIF5	Twisted gastrulation protein homolog 1.	Follistatin-related protein 3 isoform X1.	0.511
LOC111142744	LOC111139315	A0A2Y9IT89	A0A2Y9IMK0	Mothers against decapentaplegic homolog.	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	0.957
LOC111142744	LOC111145504	A0A2Y9IT89	A0A2Y9J8T1	Mothers against decapentaplegic homolog.	E3 ubiquitin-protein ligase.	0.999
LOC111142744	LOC111150438	A0A2Y9IT89	A0A2Y9JVT7	Mothers against decapentaplegic homolog.	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	0.426
LOC111142744	LOC111150788	A0A2Y9IT89	A0A2Y9JSX4	Mothers against decapentaplegic homolog.	Ski-like protein.	0.620
LOC111142744	LOC111151807	A0A2Y9IT89	A0A2Y9K8A0	Mothers against decapentaplegic homolog.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.453
LOC111142744	LOC111153274	A0A2Y9IT89	A0A2Y9K338	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.938