(48 nodes) Clathrin-coated vesicle membrane network (Enhydra lutris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111142216	Ras association domain-containing protein 9. (435 aa)
	LOC111142671	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1911 aa)
	LOC111141023	Clathrin interactor 1 isoform X1. (643 aa)
	LOC111140858	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
	LOC111139248	Epsin-2 isoform X1. (640 aa)
	LOC111139355	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (155 aa)
	LOC111139608	Epsin-1 isoform X2. (602 aa)
	LOC111139189	V-type proton ATPase subunit S1. (464 aa)
	LOC111138893	AP-1 complex subunit gamma. (830 aa)
	LOC111160803	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (144 aa)
	LOC111162523	AP-1 complex subunit mu-2 isoform X1; Belongs to the adaptor complexes medium subunit family. (436 aa)
	LOC111161889	Receptor expression-enhancing protein. (184 aa)
	LOC111161173	Ribonuclease kappa. (98 aa)
	LOC111160560	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
	LOC111159822	V-type proton ATPase subunit E 1 isoform X1. (226 aa)
	LOC111159808	Adaptin ear-binding coat-associated protein 1. (274 aa)
	LOC111156988	Drebrin-like protein isoform X4. (485 aa)
	LOC111156039	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
	LOC111157446	ENTH domain-containing protein 1. (610 aa)
	LOC111155413	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
	LOC111152627	AP-3 complex subunit beta. (1102 aa)
	LOC111155049	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
	LOC111154605	Adaptin ear-binding coat-associated protein 2. (266 aa)
	LOC111153792	Neurogranin. (78 aa)
	LOC111151829	Synergin gamma isoform X1. (1389 aa)
	LOC111150515	Renin receptor isoform X1. (351 aa)
	LOC111152837	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
	LOC111152802	AP-1 complex subunit gamma. (829 aa)
	LOC111151299	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (870 aa)
	LOC111151745	Epsin-3. (636 aa)
	LOC111151383	AP complex subunit beta. (951 aa)
	LOC111151260	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
	LOC111151188	V-type proton ATPase catalytic subunit A. (618 aa)
	LOC111149627	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (938 aa)
	LOC111147969	Aftiphilin isoform X1. (934 aa)
	LOC111148774	V-type proton ATPase subunit D isoform X1. (247 aa)
	LOC111148502	Uncharacterized protein C14orf79 homolog. (419 aa)
	LOC111148498	AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (455 aa)
	LOC111148044	Clathrin heavy chain linker domain-containing protein 1. (589 aa)
	LOC111148283	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1090 aa)
	LOC111146645	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (384 aa)
	LOC111145755	DENN domain-containing protein 1A. (1074 aa)
	LOC111145430	Vesicular acetylcholine transporter. (517 aa)
	LOC111146117	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
	LOC111145614	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
	LOC111143472	V-type proton ATPase 21 kDa proteolipid subunit isoform X1; Belongs to the V-ATPase proteolipid subunit family. (248 aa)
	LOC111144152	AP-1 complex subunit mu-1 isoform X2; Belongs to the adaptor complexes medium subunit family. (435 aa)
	LOC111143082	SH3-containing GRB2-like protein 3-interacting protein 1. (828 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111138893	LOC111139248	A0A2Y9IDW0	A0A2Y9IIV6	AP-1 complex subunit gamma.	Epsin-2 isoform X1.	0.671
LOC111138893	LOC111139355	A0A2Y9IDW0	A0A2Y9IGA0	AP-1 complex subunit gamma.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.979
LOC111138893	LOC111139608	A0A2Y9IDW0	A0A2Y9IG98	AP-1 complex subunit gamma.	Epsin-1 isoform X2.	0.507
LOC111138893	LOC111140858	A0A2Y9IDW0	A0A2Y9IJI5	AP-1 complex subunit gamma.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.712
LOC111138893	LOC111141023	A0A2Y9IDW0	A0A2Y9INX9	AP-1 complex subunit gamma.	Clathrin interactor 1 isoform X1.	0.443
LOC111138893	LOC111142671	A0A2Y9IDW0	A0A2Y9IT27	AP-1 complex subunit gamma.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.838
LOC111138893	LOC111143472	A0A2Y9IDW0	A0A2Y9J4H1	AP-1 complex subunit gamma.	V-type proton ATPase 21 kDa proteolipid subunit isoform X1; Belongs to the V-ATPase proteolipid subunit family.	0.669
LOC111138893	LOC111144152	A0A2Y9IDW0	A0A2Y9IZH4	AP-1 complex subunit gamma.	AP-1 complex subunit mu-1 isoform X2; Belongs to the adaptor complexes medium subunit family.	0.979
LOC111138893	LOC111145614	A0A2Y9IDW0	A0A2Y9J6X6	AP-1 complex subunit gamma.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.712
LOC111138893	LOC111146117	A0A2Y9IDW0	A0A2Y9J8C9	AP-1 complex subunit gamma.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.987
LOC111138893	LOC111148044	A0A2Y9IDW0	A0A2Y9JHR9	AP-1 complex subunit gamma.	Clathrin heavy chain linker domain-containing protein 1.	0.663
LOC111138893	LOC111148283	A0A2Y9IDW0	A0A2Y9JHH7	AP-1 complex subunit gamma.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.821
LOC111138893	LOC111148498	A0A2Y9IDW0	A0A2Y9JIE1	AP-1 complex subunit gamma.	AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family.	0.851
LOC111138893	LOC111151260	A0A2Y9IDW0	A0A2Y9JVL6	AP-1 complex subunit gamma.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.838
LOC111138893	LOC111151299	A0A2Y9IDW0	A0A2Y9JZI0	AP-1 complex subunit gamma.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.597
LOC111138893	LOC111151383	A0A2Y9IDW0	A0A2Y9JVQ6	AP-1 complex subunit gamma.	AP complex subunit beta.	0.887
LOC111138893	LOC111151745	A0A2Y9IDW0	A0A2Y9JXP6	AP-1 complex subunit gamma.	Epsin-3.	0.507
LOC111138893	LOC111151829	A0A2Y9IDW0	A0A2Y9K219	AP-1 complex subunit gamma.	Synergin gamma isoform X1.	0.537
LOC111138893	LOC111152627	A0A2Y9IDW0	A0A2Y9KBS3	AP-1 complex subunit gamma.	AP-3 complex subunit beta.	0.821
LOC111138893	LOC111152802	A0A2Y9IDW0	A0A2Y9K1H5	AP-1 complex subunit gamma.	AP-1 complex subunit gamma.	0.902