(29 nodes) Negative regulation of epithelial cell differentiation network (Enhydra lutris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	LOC111147279	Homeobox protein Hox-A7. (231 aa)
	LOC111147050	Protein sprouty homolog 2. (315 aa)
	LOC111144679	Nodal homolog. (348 aa)
	LOC111144379	Homeobox protein Nkx-6.3. (263 aa)
	LOC111141115	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	LOC111141735	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	LOC111141664	Serine/arginine-rich splicing factor 6 isoform X1. (344 aa)
	LOC111141296	Secreted frizzled-related protein 3. (325 aa)
	LOC111140886	Follistatin isoform X1. (344 aa)
	LOC111153716	LOW QUALITY PROTEIN: transcriptional coactivator YAP1. (422 aa)
	LOC111151954	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	LOC111147588	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	LOC111149160	Tumor protein 63-like. (333 aa)
	LOC111145671	Neurogenic locus notch homolog protein 1. (2562 aa)
	LOC111159984	GTPase KRas isoform X1. (227 aa)
	LOC111157941	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (632 aa)
	LOC111160357	Sprouty-related, EVH1 domain-containing protein 1 isoform X1. (456 aa)
	LOC111158683	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (743 aa)
	LOC111159794	Forkhead box protein J2. (567 aa)
	LOC111158128	Transcription factor SOX-9 isoform X1. (510 aa)
	LOC111156410	T-box transcription factor TBX3 isoform X1. (744 aa)
	LOC111154333	Histone-lysine N-methyltransferase EZH2 isoform X1. (751 aa)
	LOC111155546	Zinc finger E-box-binding homeobox 1 isoform X1. (1125 aa)
	LOC111155108	Transcription factor HES-1. (281 aa)
	LOC111153624	LOW QUALITY PROTEIN: sphingosine 1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (396 aa)
	LOC111155610	Protein sprouty homolog 1. (319 aa)
	LOC111152017	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
	LOC111154575	Transcription factor HES-5. (167 aa)
	LOC111154152	Protein odd-skipped-related 1. (267 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111140886	LOC111141115	A0A2Y9IJN8	A0A2Y9IT68	Follistatin isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.485
LOC111141115	LOC111140886	A0A2Y9IT68	A0A2Y9IJN8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Follistatin isoform X1.	0.485
LOC111141115	LOC111158128	A0A2Y9IT68	A0A2Y9KWM5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transcription factor SOX-9 isoform X1.	0.526
LOC111141115	LOC111159984	A0A2Y9IT68	A0A2Y9L483	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GTPase KRas isoform X1.	0.591
LOC111141735	LOC111145671	A0A2Y9INZ5	A0A2Y9JFB7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 1.	0.998
LOC111141735	LOC111154575	A0A2Y9INZ5	A0A2Y9K887	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Transcription factor HES-5.	0.644
LOC111141735	LOC111155108	A0A2Y9INZ5	A0A2Y9KHC7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Transcription factor HES-1.	0.617
LOC111141735	LOC111158128	A0A2Y9INZ5	A0A2Y9KWM5	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Transcription factor SOX-9 isoform X1.	0.458
LOC111141735	LOC111158683	A0A2Y9INZ5	A0A2Y9KZ31	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.456
LOC111145671	LOC111141735	A0A2Y9JFB7	A0A2Y9INZ5	Neurogenic locus notch homolog protein 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.998
LOC111145671	LOC111154333	A0A2Y9JFB7	A0A2Y9KJU6	Neurogenic locus notch homolog protein 1.	Histone-lysine N-methyltransferase EZH2 isoform X1.	0.470
LOC111145671	LOC111154575	A0A2Y9JFB7	A0A2Y9K887	Neurogenic locus notch homolog protein 1.	Transcription factor HES-5.	0.645
LOC111145671	LOC111155108	A0A2Y9JFB7	A0A2Y9KHC7	Neurogenic locus notch homolog protein 1.	Transcription factor HES-1.	0.637
LOC111145671	LOC111155546	A0A2Y9JFB7	A0A2Y9KJ26	Neurogenic locus notch homolog protein 1.	Zinc finger E-box-binding homeobox 1 isoform X1.	0.449
LOC111145671	LOC111158128	A0A2Y9JFB7	A0A2Y9KWM5	Neurogenic locus notch homolog protein 1.	Transcription factor SOX-9 isoform X1.	0.457
LOC111145671	LOC111158683	A0A2Y9JFB7	A0A2Y9KZ31	Neurogenic locus notch homolog protein 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.996
LOC111145671	LOC111159984	A0A2Y9JFB7	A0A2Y9L483	Neurogenic locus notch homolog protein 1.	GTPase KRas isoform X1.	0.505
LOC111147050	LOC111155610	A0A2Y9JDH6	A0A2Y9KCT8	Protein sprouty homolog 2.	Protein sprouty homolog 1.	0.534
LOC111147588	LOC111149160	A0A2Y9JNN5	A0A2Y9JL49	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	Tumor protein 63-like.	0.900
LOC111147588	LOC111153716	A0A2Y9JNN5	A0A2Y9K4U5	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	LOW QUALITY PROTEIN: transcriptional coactivator YAP1.	0.665