(18 nodes) Thyroid gland development network (Enhydra lutris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111140657	Homeobox protein Nkx-2.1. (477 aa)
	LOC111141908	Homeobox protein Nkx-2.2. (273 aa)
	LOC111141115	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	LOC111141224	Homeobox protein Nkx-2.5. (323 aa)
	LOC111142759	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	LOC111144322	RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
	LOC111144269	Homeobox protein Hox-D3. (430 aa)
	LOC111144368	Homeobox expressed in ES cells 1. (207 aa)
	LOC111147191	Homeobox protein Hox-A3. (443 aa)
	LOC111147733	Serum response factor. (508 aa)
	LOC111147192	Homeobox protein Hox-A5. (381 aa)
	LOC111151651	Homeobox protein Hox-B3. (424 aa)
	LOC111151941	Serine/threonine-protein kinase B-raf isoform X1. (817 aa)
	LOC111153179	Mothers against decapentaplegic homolog. (425 aa)
	LOC111156738	Endothelin-1. (202 aa)
	LOC111156746	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	LOC111158488	Paired box protein Pax-8 isoform X1. (499 aa)
	LOC111162236	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111140657	LOC111141115	A0A2Y9IIW5	A0A2Y9IT68	Homeobox protein Nkx-2.1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.474
LOC111140657	LOC111158488	A0A2Y9IIW5	A0A2Y9KY46	Homeobox protein Nkx-2.1.	Paired box protein Pax-8 isoform X1.	0.624
LOC111141115	LOC111140657	A0A2Y9IT68	A0A2Y9IIW5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein Nkx-2.1.	0.474
LOC111141224	LOC111147733	A0A2Y9ITU2	A0A2Y9JF31	Homeobox protein Nkx-2.5.	Serum response factor.	0.493
LOC111141908	LOC111158488	A0A2Y9ISZ8	A0A2Y9KY46	Homeobox protein Nkx-2.2.	Paired box protein Pax-8 isoform X1.	0.445
LOC111142759	LOC111144322	A0A2Y9IWM6	A0A2Y9J054	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	RAF proto-oncogene serine/threonine-protein kinase isoform X1.	0.684
LOC111142759	LOC111151941	A0A2Y9IWM6	A0A2Y9JXN1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Serine/threonine-protein kinase B-raf isoform X1.	0.818
LOC111142759	LOC111153179	A0A2Y9IWM6	A0A2Y9K3C9	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Mothers against decapentaplegic homolog.	0.942
LOC111142759	LOC111162236	A0A2Y9IWM6	A0A2Y9LAC7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.989
LOC111144322	LOC111142759	A0A2Y9J054	A0A2Y9IWM6	RAF proto-oncogene serine/threonine-protein kinase isoform X1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.684
LOC111144322	LOC111151941	A0A2Y9J054	A0A2Y9JXN1	RAF proto-oncogene serine/threonine-protein kinase isoform X1.	Serine/threonine-protein kinase B-raf isoform X1.	0.992
LOC111144322	LOC111162236	A0A2Y9J054	A0A2Y9LAC7	RAF proto-oncogene serine/threonine-protein kinase isoform X1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.684
LOC111147191	LOC111147192	A0A2Y9JCM5	A0A2Y9JGL2	Homeobox protein Hox-A3.	Homeobox protein Hox-A5.	0.726
LOC111147192	LOC111147191	A0A2Y9JGL2	A0A2Y9JCM5	Homeobox protein Hox-A5.	Homeobox protein Hox-A3.	0.726
LOC111147733	LOC111141224	A0A2Y9JF31	A0A2Y9ITU2	Serum response factor.	Homeobox protein Nkx-2.5.	0.493
LOC111151941	LOC111142759	A0A2Y9JXN1	A0A2Y9IWM6	Serine/threonine-protein kinase B-raf isoform X1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.818
LOC111151941	LOC111144322	A0A2Y9JXN1	A0A2Y9J054	Serine/threonine-protein kinase B-raf isoform X1.	RAF proto-oncogene serine/threonine-protein kinase isoform X1.	0.992
LOC111151941	LOC111158488	A0A2Y9JXN1	A0A2Y9KY46	Serine/threonine-protein kinase B-raf isoform X1.	Paired box protein Pax-8 isoform X1.	0.439
LOC111151941	LOC111162236	A0A2Y9JXN1	A0A2Y9LAC7	Serine/threonine-protein kinase B-raf isoform X1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.818
LOC111153179	LOC111142759	A0A2Y9K3C9	A0A2Y9IWM6	Mothers against decapentaplegic homolog.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.942