(10 nodes) Histone H2B ubiquitination network (Enhydra lutris)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111155054	E3 ubiquitin-protein ligase DTX3L. (745 aa)
	LOC111160609	RNA polymerase-associated protein LEO1 isoform X1. (665 aa)
	LOC111159484	RNA polymerase-associated protein CTR9 homolog isoform X1. (1173 aa)
	LOC111162266	E3 ubiquitin protein ligase; Belongs to the BRE1 family. (1001 aa)
	LOC111161378	RNA polymerase II-associated factor 1 homolog isoform X2. (536 aa)
	LOC111151037	Parafibromin. (531 aa)
	LOC111147879	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa)
	LOC111146135	E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
	LOC111140117	RNA polymerase-associated protein LEO1-like. (298 aa)
	LOC111139306	WW domain-containing adapter protein with coiled-coil isoform X1. (652 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111139306	LOC111140117	A0A2Y9IF17	A0A2Y9IIW4	WW domain-containing adapter protein with coiled-coil isoform X1.	RNA polymerase-associated protein LEO1-like.	0.633
LOC111139306	LOC111146135	A0A2Y9IF17	A0A2Y9J8G5	WW domain-containing adapter protein with coiled-coil isoform X1.	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	0.839
LOC111139306	LOC111151037	A0A2Y9IF17	A0A2Y9JTS6	WW domain-containing adapter protein with coiled-coil isoform X1.	Parafibromin.	0.598
LOC111139306	LOC111159484	A0A2Y9IF17	A0A2Y9L8C4	WW domain-containing adapter protein with coiled-coil isoform X1.	RNA polymerase-associated protein CTR9 homolog isoform X1.	0.591
LOC111139306	LOC111160609	A0A2Y9IF17	A0A2Y9LDD1	WW domain-containing adapter protein with coiled-coil isoform X1.	RNA polymerase-associated protein LEO1 isoform X1.	0.633
LOC111139306	LOC111161378	A0A2Y9IF17	A0A2Y9L395	WW domain-containing adapter protein with coiled-coil isoform X1.	RNA polymerase II-associated factor 1 homolog isoform X2.	0.627
LOC111139306	LOC111162266	A0A2Y9IF17	A0A2Y9L896	WW domain-containing adapter protein with coiled-coil isoform X1.	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	0.875
LOC111140117	LOC111139306	A0A2Y9IIW4	A0A2Y9IF17	RNA polymerase-associated protein LEO1-like.	WW domain-containing adapter protein with coiled-coil isoform X1.	0.633
LOC111140117	LOC111146135	A0A2Y9IIW4	A0A2Y9J8G5	RNA polymerase-associated protein LEO1-like.	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	0.791
LOC111140117	LOC111151037	A0A2Y9IIW4	A0A2Y9JTS6	RNA polymerase-associated protein LEO1-like.	Parafibromin.	0.999
LOC111140117	LOC111159484	A0A2Y9IIW4	A0A2Y9L8C4	RNA polymerase-associated protein LEO1-like.	RNA polymerase-associated protein CTR9 homolog isoform X1.	0.997
LOC111140117	LOC111161378	A0A2Y9IIW4	A0A2Y9L395	RNA polymerase-associated protein LEO1-like.	RNA polymerase II-associated factor 1 homolog isoform X2.	0.998
LOC111140117	LOC111162266	A0A2Y9IIW4	A0A2Y9L896	RNA polymerase-associated protein LEO1-like.	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	0.786
LOC111146135	LOC111139306	A0A2Y9J8G5	A0A2Y9IF17	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	WW domain-containing adapter protein with coiled-coil isoform X1.	0.839
LOC111146135	LOC111140117	A0A2Y9J8G5	A0A2Y9IIW4	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	RNA polymerase-associated protein LEO1-like.	0.791
LOC111146135	LOC111147879	A0A2Y9J8G5	A0A2Y9JFM5	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.437
LOC111146135	LOC111151037	A0A2Y9J8G5	A0A2Y9JTS6	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	Parafibromin.	0.762
LOC111146135	LOC111159484	A0A2Y9J8G5	A0A2Y9L8C4	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	RNA polymerase-associated protein CTR9 homolog isoform X1.	0.691
LOC111146135	LOC111160609	A0A2Y9J8G5	A0A2Y9LDD1	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	RNA polymerase-associated protein LEO1 isoform X1.	0.791
LOC111146135	LOC111161378	A0A2Y9J8G5	A0A2Y9L395	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	RNA polymerase II-associated factor 1 homolog isoform X2.	0.744