(44 nodes) Somatic stem cell population maintenance network (Enhydra lutris)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111150307	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	LOC111150414	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1454 aa)
	LOC111146987	DNA ligase. (911 aa)
	LOC111149018	Mediator of RNA polymerase II transcription subunit 28. (175 aa)
	LOC111146663	Mediator of RNA polymerase II transcription subunit 30 isoform X1. (178 aa)
	LOC111147089	cullin-4A isoform X2; Belongs to the cullin family. (765 aa)
	LOC111146585	Krueppel-like factor 10. (480 aa)
	LOC111145789	Mediator of RNA polymerase II transcription subunit 27 isoform X1. (311 aa)
	LOC111146516	Zinc fingers and homeoboxes protein 2. (841 aa)
	LOC111144836	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
	LOC111144679	Nodal homolog. (348 aa)
	LOC111144769	LIM domain-binding protein 1 isoform X1. (411 aa)
	LOC111144482	Secreted frizzled-related protein 1-like. (250 aa)
	LOC111144443	Secreted frizzled-related protein 1. (314 aa)
	LOC111144322	RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
	LOC111142727	Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (747 aa)
	LOC111141764	Sal-like protein 4 isoform X1. (1056 aa)
	LOC111141115	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	LOC111142737	Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (232 aa)
	LOC111141032	Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (233 aa)
	LOC111140842	Nipped-B protein. (2803 aa)
	LOC111140164	LOW QUALITY PROTEIN: mRNA decay activator protein ZFP36L2-like. (494 aa)
	LOC111139815	Structural maintenance of chromosomes protein. (1233 aa)
	LOC111160085	Leukemia inhibitory factor. (202 aa)
	LOC111160986	Mediator of RNA polymerase II transcription subunit 12. (2095 aa)
	LOC111151241	Signal transducer and activator of transcription. (802 aa)
	LOC111161348	Mediator of RNA polymerase II transcription subunit 28. (175 aa)
	LOC111162000	Vacuolar protein sorting-associated protein 72 homolog isoform X1. (374 aa)
	LOC111151807	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	LOC111154499	Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (651 aa)
	LOC111155108	Transcription factor HES-1. (281 aa)
	LOC111155923	mRNA decay activator protein ZFP36L2. (493 aa)
	LOC111159664	Homeobox protein NANOG. (310 aa)
	LOC111153891	B-cell CLL/lymphoma 9-like protein isoform X1. (1498 aa)
	LOC111158128	Transcription factor SOX-9 isoform X1. (510 aa)
	LOC111158202	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	LOC111158222	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	LOC111159956	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (144 aa)
	LOC111153716	LOW QUALITY PROTEIN: transcriptional coactivator YAP1. (422 aa)
	LOC111151941	Serine/threonine-protein kinase B-raf isoform X1. (817 aa)
	LOC111149489	Low-density lipoprotein receptor-related protein 5. (2138 aa)
	LOC111149312	LIM domain-binding protein 2 isoform X1. (373 aa)
	LOC111149307	RE1-silencing transcription factor. (1074 aa)
	LOC111151280	Telomere-associated protein RIF1 isoform X1. (2478 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111139815	LOC111140842	A0A2Y9IH34	A0A2Y9IJB4	Structural maintenance of chromosomes protein.	Nipped-B protein.	0.997
LOC111139815	LOC111160986	A0A2Y9IH34	A0A2Y9L2I3	Structural maintenance of chromosomes protein.	Mediator of RNA polymerase II transcription subunit 12.	0.426
LOC111140164	LOC111155923	A0A2Y9IIY0	A0A2Y9KL10	LOW QUALITY PROTEIN: mRNA decay activator protein ZFP36L2-like.	mRNA decay activator protein ZFP36L2.	0.900
LOC111140842	LOC111139815	A0A2Y9IJB4	A0A2Y9IH34	Nipped-B protein.	Structural maintenance of chromosomes protein.	0.997
LOC111140842	LOC111160986	A0A2Y9IJB4	A0A2Y9L2I3	Nipped-B protein.	Mediator of RNA polymerase II transcription subunit 12.	0.465
LOC111141032	LOC111142727	A0A2Y9IP00	A0A2Y9IWH7	Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery.	Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.947
LOC111141032	LOC111145789	A0A2Y9IP00	A0A2Y9JAK2	Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery.	Mediator of RNA polymerase II transcription subunit 27 isoform X1.	0.954
LOC111141032	LOC111146663	A0A2Y9IP00	A0A2Y9JJM2	Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery.	Mediator of RNA polymerase II transcription subunit 30 isoform X1.	0.918
LOC111141032	LOC111149018	A0A2Y9IP00	A0A2Y9JKX4	Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery.	Mediator of RNA polymerase II transcription subunit 28.	0.755
LOC111141032	LOC111150414	A0A2Y9IP00	A0A2Y9JRA3	Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery.	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.958
LOC111141032	LOC111154499	A0A2Y9IP00	A0A2Y9K9Q7	Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery.	Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.967
LOC111141032	LOC111159956	A0A2Y9IP00	A0A2Y9KZ71	Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery.	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.943
LOC111141032	LOC111160986	A0A2Y9IP00	A0A2Y9L2I3	Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery.	Mediator of RNA polymerase II transcription subunit 12.	0.863
LOC111141032	LOC111161348	A0A2Y9IP00	A0A2Y9L436	Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery.	Mediator of RNA polymerase II transcription subunit 28.	0.755
LOC111141115	LOC111150307	A0A2Y9IT68	A0A2Y9JS03	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.487
LOC111141115	LOC111151241	A0A2Y9IT68	A0A2Y9K559	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Signal transducer and activator of transcription.	0.444
LOC111141115	LOC111151807	A0A2Y9IT68	A0A2Y9K8A0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.777
LOC111141115	LOC111158128	A0A2Y9IT68	A0A2Y9KWM5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transcription factor SOX-9 isoform X1.	0.526
LOC111141115	LOC111159664	A0A2Y9IT68	A0A2Y9KW02	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein NANOG.	0.524
LOC111141115	LOC111160085	A0A2Y9IT68	A0A2Y9KZU4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Leukemia inhibitory factor.	0.537