(20 nodes) Enteroendocrine cell differentiation network (Enhydra lutris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111158579	Pancreas/duodenum homeobox protein 1. (281 aa)
	LOC111151852	Paired box protein Pax-4. (298 aa)
	LOC111152017	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
	LOC111153691	SID1 transmembrane family member 2 isoform X1. (853 aa)
	LOC111155108	Transcription factor HES-1. (281 aa)
	LOC111156661	Bone morphogenetic protein 6. (509 aa)
	LOC111157852	Homeobox protein Nkx-6.1. (368 aa)
	LOC111156293	3-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
	LOC111158683	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (743 aa)
	LOC111162047	Bone morphogenetic protein 4 isoform X1. (456 aa)
	LOC111160222	LOW QUALITY PROTEIN: growth/differentiation factor 11. (407 aa)
	LOC111141652	Hepatocyte nuclear factor 4-alpha isoform X1. (503 aa)
	LOC111142563	Transcription factor GATA-6. (592 aa)
	LOC111144379	Homeobox protein Nkx-6.3. (263 aa)
	LOC111145443	Homeobox protein Nkx-6.2. (278 aa)
	LOC111146020	Class A basic helix-loop-helix protein 15. (187 aa)
	LOC111147246	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	LOC111147841	DNA-binding protein RFX6. (928 aa)
	LOC111149573	Paired box protein Pax-6 isoform X1. (436 aa)
	LOC111152343	Bone morphogenetic protein 5 isoform X1. (454 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111142563	LOC111149573	A0A2Y9IS32	A0A2Y9JMR1	Transcription factor GATA-6.	Paired box protein Pax-6 isoform X1.	0.524
LOC111142563	LOC111162047	A0A2Y9IS32	A0A2Y9LJR5	Transcription factor GATA-6.	Bone morphogenetic protein 4 isoform X1.	0.595
LOC111144379	LOC111147841	A0A2Y9J0E7	A0A2Y9JFH4	Homeobox protein Nkx-6.3.	DNA-binding protein RFX6.	0.457
LOC111147841	LOC111144379	A0A2Y9JFH4	A0A2Y9J0E7	DNA-binding protein RFX6.	Homeobox protein Nkx-6.3.	0.457
LOC111147841	LOC111149573	A0A2Y9JFH4	A0A2Y9JMR1	DNA-binding protein RFX6.	Paired box protein Pax-6 isoform X1.	0.466
LOC111147841	LOC111151852	A0A2Y9JFH4	A0A2Y9K8E9	DNA-binding protein RFX6.	Paired box protein Pax-4.	0.622
LOC111147841	LOC111157852	A0A2Y9JFH4	A0A2Y9KMV4	DNA-binding protein RFX6.	Homeobox protein Nkx-6.1.	0.422
LOC111147841	LOC111158579	A0A2Y9JFH4	A0A2Y9KYL1	DNA-binding protein RFX6.	Pancreas/duodenum homeobox protein 1.	0.445
LOC111149573	LOC111142563	A0A2Y9JMR1	A0A2Y9IS32	Paired box protein Pax-6 isoform X1.	Transcription factor GATA-6.	0.524
LOC111149573	LOC111147841	A0A2Y9JMR1	A0A2Y9JFH4	Paired box protein Pax-6 isoform X1.	DNA-binding protein RFX6.	0.466
LOC111149573	LOC111152017	A0A2Y9JMR1	A0A2Y9K926	Paired box protein Pax-6 isoform X1.	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	0.491
LOC111149573	LOC111158579	A0A2Y9JMR1	A0A2Y9KYL1	Paired box protein Pax-6 isoform X1.	Pancreas/duodenum homeobox protein 1.	0.481
LOC111149573	LOC111162047	A0A2Y9JMR1	A0A2Y9LJR5	Paired box protein Pax-6 isoform X1.	Bone morphogenetic protein 4 isoform X1.	0.516
LOC111151852	LOC111147841	A0A2Y9K8E9	A0A2Y9JFH4	Paired box protein Pax-4.	DNA-binding protein RFX6.	0.622
LOC111151852	LOC111158579	A0A2Y9K8E9	A0A2Y9KYL1	Paired box protein Pax-4.	Pancreas/duodenum homeobox protein 1.	0.445
LOC111152017	LOC111149573	A0A2Y9K926	A0A2Y9JMR1	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	Paired box protein Pax-6 isoform X1.	0.491
LOC111152343	LOC111162047	A0A2Y9JZS0	A0A2Y9LJR5	Bone morphogenetic protein 5 isoform X1.	Bone morphogenetic protein 4 isoform X1.	0.667
LOC111155108	LOC111158683	A0A2Y9KHC7	A0A2Y9KZ31	Transcription factor HES-1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.542
LOC111156661	LOC111162047	A0A2Y9KJX6	A0A2Y9LJR5	Bone morphogenetic protein 6.	Bone morphogenetic protein 4 isoform X1.	0.964
LOC111157852	LOC111147841	A0A2Y9KMV4	A0A2Y9JFH4	Homeobox protein Nkx-6.1.	DNA-binding protein RFX6.	0.422