STRINGSTRING
LOC111162203 LOC111162203 LOC111138616 LOC111138616 LOC111139266 LOC111139266 LOC111139993 LOC111139993 LOC111141409 LOC111141409 LOC111142134 LOC111142134 LOC111142001 LOC111142001 LOC111142184 LOC111142184 LOC111142084 LOC111142084 LOC111142104 LOC111142104 LOC111142498 LOC111142498 LOC111142587 LOC111142587 LOC111141629 LOC111141629 LOC111143247 LOC111143247 LOC111143278 LOC111143278 LOC111142961 LOC111142961 LOC111144881 LOC111144881 LOC111144929 LOC111144929 LOC111145298 LOC111145298 LOC111145638 LOC111145638 LOC111145665 LOC111145665 LOC111144982 LOC111144982 LOC111145691 LOC111145691 LOC111145299 LOC111145299 LOC111144673 LOC111144673 LOC111144855 LOC111144855 LOC111147387 LOC111147387 LOC111145976 LOC111145976 LOC111147900 LOC111147900 LOC111147573 LOC111147573 LOC111148511 LOC111148511 LOC111148542 LOC111148542 LOC111161589 LOC111161589 LOC111149803 LOC111149803 LOC111150761 LOC111150761 LOC111150816 LOC111150816 LOC111150863 LOC111150863 LOC111151216 LOC111151216 LOC111152144 LOC111152144 LOC111152264 LOC111152264 LOC111152858 LOC111152858 LOC111153007 LOC111153007 LOC111153400 LOC111153400 LOC111152653 LOC111152653 LOC111153446 LOC111153446 LOC111154830 LOC111154830 LOC111155429 LOC111155429 LOC111154461 LOC111154461 LOC111155802 LOC111155802 LOC111155943 LOC111155943 LOC111154283 LOC111154283 LOC111155286 LOC111155286 LOC111158305 LOC111158305 LOC111158692 LOC111158692 LOC111157029 LOC111157029 LOC111159115 LOC111159115 LOC111159051 LOC111159051 LOC111160161 LOC111160161 LOC111157388 LOC111157388 LOC111158100 LOC111158100 LOC111160147 LOC111160147
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111162203Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (312 aa)
LOC111138616Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (545 aa)
LOC111139266Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (483 aa)
LOC111139993C-1-tetrahydrofolate synthase, cytoplasmic. (940 aa)
LOC111141409Acyl-coenzyme A thioesterase 8 isoform X1. (317 aa)
LOC111142134Probable imidazolonepropionase. (426 aa)
LOC111142001Glutaminase kidney isoform, mitochondrial isoform X1. (674 aa)
LOC111142184Histidine ammonia-lyase; Belongs to the PAL/histidase family. (657 aa)
LOC11114208410-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
LOC111142104Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (486 aa)
LOC111142498Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (492 aa)
LOC111142587Malic enzyme. (589 aa)
LOC111141629Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
LOC111143247Kynurenine--oxoglutarate transaminase 3 isoform X1. (454 aa)
LOC111143278Glutamate--cysteine ligase regulatory subunit isoform X1. (274 aa)
LOC111142961D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1. (578 aa)
LOC111144881Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa)
LOC111144929Aspartate aminotransferase. (413 aa)
LOC1111452984-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1; Belongs to the DapA family. (327 aa)
LOC111145638Malate dehydrogenase. (338 aa)
LOC111145665Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (589 aa)
LOC111144982Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
LOC111145691Argininosuccinate lyase isoform X1. (520 aa)
LOC111145299Uncharacterized protein C10orf62 homolog. (227 aa)
LOC111144673Putative malate dehydrogenase 1B isoform X1. (532 aa)
LOC111144855Ornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
LOC111147387Succinate dehydrogenase assembly factor 3, mitochondrial. (125 aa)
LOC111145976Argininosuccinate synthase. (412 aa)
LOC111147900Malate dehydrogenase. (353 aa)
LOC111147573Malic enzyme. (572 aa)
LOC1111485112-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). (455 aa)
LOC111148542D-glutamate cyclase, mitochondrial. (621 aa)
LOC111161589Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (461 aa)
LOC111149803Glutamate decarboxylase 1 isoform X1. (594 aa)
LOC111150761Fumarate hydratase, mitochondrial. (508 aa)
LOC111150816Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
LOC111150863Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (531 aa)
LOC111151216ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
LOC111152144Omega-amidase NIT2. (283 aa)
LOC111152264Glutamate--cysteine ligase catalytic subunit isoform X1. (637 aa)
LOC111152858acyl-CoA synthetase family member 3, mitochondrial isoform X1. (633 aa)
LOC111153007Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
LOC111153400Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (687 aa)
LOC111152653Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (451 aa)
LOC111153446Methionine synthase reductase isoform X1. (711 aa)
LOC111154830Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (564 aa)
LOC111155429Hydroxyacid-oxoacid transhydrogenase, mitochondrial. (467 aa)
LOC111154461Malic enzyme. (604 aa)
LOC111155802Formimidoyltransferase-cyclodeaminase. (541 aa)
LOC1111559433-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa)
LOC111154283LOW QUALITY PROTEIN: glutamate decarboxylase 1-like. (543 aa)
LOC11115528628S ribosomal protein S36, mitochondrial. (103 aa)
LOC111158305D-aspartate oxidase. (339 aa)
LOC111158692Monofunctional C1-tetrahydrofolate synthase, mitochondrial. (978 aa)
LOC1111570292-oxoglutarate dehydrogenase, mitochondrial isoform X1. (1023 aa)
LOC111159115LOW QUALITY PROTEIN: urocanate hydratase. (676 aa)
LOC11115905110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
LOC111160161Glutaminase liver isoform, mitochondrial isoform X2. (603 aa)
LOC111157388Aspartate aminotransferase. (430 aa)
LOC111158100N-acetylglutamate synthase, mitochondrial. (534 aa)
LOC111160147Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
Your Current Organism:
Enhydra lutris
NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni
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