(45 nodes) Regulation of myoblast differentiation network (Enhydra lutris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111161096	LOW QUALITY PROTEIN: myocardin. (957 aa)
	LOC111160240	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
	LOC111158683	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (743 aa)
	LOC111157077	Insulin-like growth factor-binding protein 3 isoform X2. (299 aa)
	LOC111158128	Transcription factor SOX-9 isoform X1. (510 aa)
	LOC111157888	Prickle-like protein 1. (832 aa)
	LOC111156410	T-box transcription factor TBX3 isoform X1. (744 aa)
	LOC111154732	DNA-binding protein inhibitor ID-3. (119 aa)
	LOC111156095	Transcription factor SOX-8. (462 aa)
	LOC111157422	C-C motif chemokine. (99 aa)
	LOC111157043	Kelch-like protein 41. (606 aa)
	LOC111155950	Transmembrane protein 182. (229 aa)
	LOC111153834	Cell adhesion molecule-related/down-regulated by oncogenes. (1260 aa)
	LOC111152376	Peroxisome proliferator-activated receptor delta. (441 aa)
	LOC111152248	Tumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family. (234 aa)
	LOC111153229	Activating signal cointegrator 1 isoform X1. (581 aa)
	LOC111151332	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	LOC111152183	Mitogen-activated protein kinase. (360 aa)
	LOC111149712	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
	LOC111149152	C-X-C motif chemokine. (155 aa)
	LOC111148655	mRNA decay activator protein ZFP36L1. (338 aa)
	LOC111148615	Brother of CDO isoform X1. (1239 aa)
	LOC111148445	Myocyte-specific enhancer factor 2C isoform X1. (483 aa)
	LOC111149252	C-X-C motif chemokine. (98 aa)
	LOC111145671	Neurogenic locus notch homolog protein 1. (2562 aa)
	LOC111147502	Mitogen-activated protein kinase kinase kinase 5 isoform X1. (1364 aa)
	LOC111147437	Sclerostin domain-containing protein 1. (206 aa)
	LOC111146368	Volume-regulated anion channel subunit LRRC8A. (810 aa)
	LOC111145240	Hypoxia-inducible factor 1-alpha inhibitor. (352 aa)
	LOC111145106	LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 2. (363 aa)
	LOC111142272	Myogenic factor 6. (242 aa)
	LOC111143259	XK-related protein. (400 aa)
	LOC111142992	Akirin-1. (192 aa)
	LOC111143851	Growth/differentiation factor 8. (375 aa)
	LOC111142355	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
	LOC111138631	Transcription factor SOX. (473 aa)
	LOC111138641	Rho family-interacting cell polarization regulator 2 isoform X1. (1085 aa)
	LOC111141178	C-X-C motif chemokine 14. (99 aa)
	LOC111140997	Ran-binding protein 3-like isoform X1. (489 aa)
	LOC111140804	Steroid receptor RNA activator 1 isoform X1. (227 aa)
	LOC111140675	CKLF-like MARVEL transmembrane domain-containing protein 5. (156 aa)
	LOC111161420	Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
	LOC111162155	Muscleblind-like protein 3 isoform X1. (369 aa)
	LOC111161860	Tumor necrosis factor ligand superfamily member 14 isoform X1; Belongs to the tumor necrosis factor family. (241 aa)
	LOC111162047	Bone morphogenetic protein 4 isoform X1. (456 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111138631	LOC111156095	A0A2Y9IJZ2	A0A2Y9KM00	Transcription factor SOX.	Transcription factor SOX-8.	0.451
LOC111141178	LOC111149152	A0A2Y9IKR3	A0A2Y9JVV4	C-X-C motif chemokine 14.	C-X-C motif chemokine.	0.953
LOC111141178	LOC111149252	A0A2Y9IKR3	A0A2Y9JLE5	C-X-C motif chemokine 14.	C-X-C motif chemokine.	0.949
LOC111141178	LOC111157422	A0A2Y9IKR3	A0A2Y9KLJ2	C-X-C motif chemokine 14.	C-C motif chemokine.	0.940
LOC111142272	LOC111142355	A0A2Y9IRW3	A0A2Y9IYU5	Myogenic factor 6.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.685
LOC111142272	LOC111143851	A0A2Y9IRW3	A0A2Y9IYR4	Myogenic factor 6.	Growth/differentiation factor 8.	0.568
LOC111142272	LOC111148445	A0A2Y9IRW3	A0A2Y9JM62	Myogenic factor 6.	Myocyte-specific enhancer factor 2C isoform X1.	0.674
LOC111142272	LOC111157043	A0A2Y9IRW3	A0A2Y9KJE7	Myogenic factor 6.	Kelch-like protein 41.	0.440
LOC111142355	LOC111142272	A0A2Y9IYU5	A0A2Y9IRW3	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Myogenic factor 6.	0.685
LOC111142355	LOC111143851	A0A2Y9IYU5	A0A2Y9IYR4	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Growth/differentiation factor 8.	0.848
LOC111142355	LOC111148445	A0A2Y9IYU5	A0A2Y9JM62	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Myocyte-specific enhancer factor 2C isoform X1.	0.725
LOC111143851	LOC111142272	A0A2Y9IYR4	A0A2Y9IRW3	Growth/differentiation factor 8.	Myogenic factor 6.	0.568
LOC111143851	LOC111142355	A0A2Y9IYR4	A0A2Y9IYU5	Growth/differentiation factor 8.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.848
LOC111143851	LOC111148445	A0A2Y9IYR4	A0A2Y9JM62	Growth/differentiation factor 8.	Myocyte-specific enhancer factor 2C isoform X1.	0.439
LOC111145240	LOC111145671	A0A2Y9J4D2	A0A2Y9JFB7	Hypoxia-inducible factor 1-alpha inhibitor.	Neurogenic locus notch homolog protein 1.	0.739
LOC111145671	LOC111145240	A0A2Y9JFB7	A0A2Y9J4D2	Neurogenic locus notch homolog protein 1.	Hypoxia-inducible factor 1-alpha inhibitor.	0.739
LOC111145671	LOC111149712	A0A2Y9JFB7	A0A2Y9JYN0	Neurogenic locus notch homolog protein 1.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.478
LOC111145671	LOC111152248	A0A2Y9JFB7	A0A2Y9K411	Neurogenic locus notch homolog protein 1.	Tumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family.	0.533
LOC111145671	LOC111158128	A0A2Y9JFB7	A0A2Y9KWM5	Neurogenic locus notch homolog protein 1.	Transcription factor SOX-9 isoform X1.	0.457
LOC111145671	LOC111158683	A0A2Y9JFB7	A0A2Y9KZ31	Neurogenic locus notch homolog protein 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.996