(16 nodes) Embryonic camera-type eye morphogenesis network (Enhydra lutris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111149573	Paired box protein Pax-6 isoform X1. (436 aa)
	LOC111156340	Lysine-specific demethylase 2B isoform X1. (1327 aa)
	LOC111156640	Forkhead box protein F2. (449 aa)
	LOC111155546	Zinc finger E-box-binding homeobox 1 isoform X1. (1125 aa)
	LOC111156728	Transcription factor AP-2-alpha isoform X3. (446 aa)
	LOC111153296	Stimulated by retinoic acid gene 6 protein homolog isoform X2. (658 aa)
	LOC111155751	Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (173 aa)
	LOC111151859	Homeodomain-interacting protein kinase 2 isoform X1. (1233 aa)
	LOC111152582	Aldehyde dehydrogenase family 1 member A3 isoform X1; Belongs to the aldehyde dehydrogenase family. (512 aa)
	LOC111151576	T-box transcription factor TBX2. (713 aa)
	LOC111150797	Prospero homeobox protein 1 isoform X1. (738 aa)
	LOC111147852	Cbp/p300-interacting transactivator 2. (273 aa)
	LOC111142858	Homeodomain-interacting protein kinase 1 isoform X1. (1210 aa)
	LOC111143246	Phosphatase and actin regulator. (705 aa)
	LOC111142350	Transcription factor Sp3. (781 aa)
	LOC111142213	Fibroblast growth factor receptor substrate 2. (508 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111147852	LOC111156728	A0A2Y9JGV1	A0A2Y9KIR6	Cbp/p300-interacting transactivator 2.	Transcription factor AP-2-alpha isoform X3.	0.487
LOC111149573	LOC111156728	A0A2Y9JMR1	A0A2Y9KIR6	Paired box protein Pax-6 isoform X1.	Transcription factor AP-2-alpha isoform X3.	0.459
LOC111152582	LOC111153296	A0A2Y9K0X1	A0A2Y9KES6	Aldehyde dehydrogenase family 1 member A3 isoform X1; Belongs to the aldehyde dehydrogenase family.	Stimulated by retinoic acid gene 6 protein homolog isoform X2.	0.483
LOC111153296	LOC111152582	A0A2Y9KES6	A0A2Y9K0X1	Stimulated by retinoic acid gene 6 protein homolog isoform X2.	Aldehyde dehydrogenase family 1 member A3 isoform X1; Belongs to the aldehyde dehydrogenase family.	0.483
LOC111156728	LOC111147852	A0A2Y9KIR6	A0A2Y9JGV1	Transcription factor AP-2-alpha isoform X3.	Cbp/p300-interacting transactivator 2.	0.487
LOC111156728	LOC111149573	A0A2Y9KIR6	A0A2Y9JMR1	Transcription factor AP-2-alpha isoform X3.	Paired box protein Pax-6 isoform X1.	0.459