(33 nodes) Positive regulation of smooth muscle cell proliferation network (Enhydra lutris)

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Predicted Interactions

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co-expression

protein homology

Your Input:
	LOC111143252	Insulin-like growth factor-binding protein 5. (271 aa)
	LOC111162047	Bone morphogenetic protein 4 isoform X1. (456 aa)
	LOC111162394	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1619 aa)
	LOC111161172	Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
	LOC111161597	Thrombospondin-1. (1170 aa)
	LOC111159572	P2Y purinoceptor 6. (328 aa)
	LOC111158091	Serine/threonine-protein kinase/endoribonuclease IRE1. (975 aa)
	LOC111157602	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
	LOC111157534	Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (243 aa)
	LOC111159933	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	LOC111159794	Forkhead box protein J2. (567 aa)
	LOC111156825	Extracellular sulfatase Sulf-1 isoform X1. (1107 aa)
	LOC111156738	Endothelin-1. (202 aa)
	LOC111156005	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (341 aa)
	LOC111154798	Low density lipoprotein receptor adapter protein 1 isoform X1. (309 aa)
	LOC111154723	Mitofusin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (762 aa)
	LOC111154575	Transcription factor HES-5. (167 aa)
	LOC111152768	Cadherin-13. (713 aa)
	LOC111152294	Allograft inflammatory factor 1 isoform X1. (147 aa)
	LOC111152248	Tumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family. (234 aa)
	LOC111151550	A disintegrin and metalloproteinase with thrombospondin motifs 1. (951 aa)
	LOC111151595	Neurofibromin isoform X1. (2841 aa)
	LOC111151546	Prohibitin. (272 aa)
	LOC111151239	Alpha-2-antiplasmin isoform X1; Belongs to the serpin family. (548 aa)
	LOC111146169	Nuclear receptor subfamily 4 group A member 3 isoform X1. (652 aa)
	LOC111147365	Interleukin-6 isoform X2. (212 aa)
	LOC111144836	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
	LOC111143744	Forkhead box protein P1 isoform X4. (693 aa)
	LOC111143174	Transcription factor AP-1; Belongs to the bZIP family. (334 aa)
	LOC111141144	Proheparin-binding EGF-like growth factor. (208 aa)
	LOC111141074	Calcitonin gene-related peptide type 1 receptor; Belongs to the G-protein coupled receptor 2 family. (462 aa)
	LOC111138851	Myocyte-specific enhancer factor 2D isoform X1. (517 aa)
	LOC111140848	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1113 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111140848	LOC111147365	A0A2Y9IJC4	A0A2Y9JDG5	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	Interleukin-6 isoform X2.	0.823
LOC111140848	LOC111156005	A0A2Y9IJC4	A0A2Y9KEQ6	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.857
LOC111140848	LOC111157534	A0A2Y9IJC4	A0A2Y9KZY4	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family.	0.999
LOC111140848	LOC111159933	A0A2Y9IJC4	A0A2Y9KZ18	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.825
LOC111141144	LOC111151550	A0A2Y9IPD1	A0A2Y9JWX3	Proheparin-binding EGF-like growth factor.	A disintegrin and metalloproteinase with thrombospondin motifs 1.	0.435
LOC111141144	LOC111156005	A0A2Y9IPD1	A0A2Y9KEQ6	Proheparin-binding EGF-like growth factor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.441
LOC111143174	LOC111147365	A0A2Y9IV49	A0A2Y9JDG5	Transcription factor AP-1; Belongs to the bZIP family.	Interleukin-6 isoform X2.	0.949
LOC111143174	LOC111152248	A0A2Y9IV49	A0A2Y9K411	Transcription factor AP-1; Belongs to the bZIP family.	Tumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family.	0.951
LOC111143252	LOC111147365	A0A2Y9IVA9	A0A2Y9JDG5	Insulin-like growth factor-binding protein 5.	Interleukin-6 isoform X2.	0.440
LOC111143252	LOC111161597	A0A2Y9IVA9	A0A2Y9LBU2	Insulin-like growth factor-binding protein 5.	Thrombospondin-1.	0.420
LOC111144836	LOC111162047	A0A2Y9J3I8	A0A2Y9LJR5	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4 isoform X1.	0.994
LOC111147365	LOC111140848	A0A2Y9JDG5	A0A2Y9IJC4	Interleukin-6 isoform X2.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.823
LOC111147365	LOC111143174	A0A2Y9JDG5	A0A2Y9IV49	Interleukin-6 isoform X2.	Transcription factor AP-1; Belongs to the bZIP family.	0.949
LOC111147365	LOC111143252	A0A2Y9JDG5	A0A2Y9IVA9	Interleukin-6 isoform X2.	Insulin-like growth factor-binding protein 5.	0.440
LOC111147365	LOC111152248	A0A2Y9JDG5	A0A2Y9K411	Interleukin-6 isoform X2.	Tumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family.	0.840
LOC111147365	LOC111156005	A0A2Y9JDG5	A0A2Y9KEQ6	Interleukin-6 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.643
LOC111147365	LOC111156738	A0A2Y9JDG5	A0A2Y9KIS9	Interleukin-6 isoform X2.	Endothelin-1.	0.512
LOC111147365	LOC111157602	A0A2Y9JDG5	A0A2Y9L0B3	Interleukin-6 isoform X2.	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	0.645
LOC111147365	LOC111159933	A0A2Y9JDG5	A0A2Y9KZ18	Interleukin-6 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.530
LOC111147365	LOC111161597	A0A2Y9JDG5	A0A2Y9LBU2	Interleukin-6 isoform X2.	Thrombospondin-1.	0.556