(32 nodes) B cell receptor signaling pathway network (Enhydra lutris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111155370	Tyrosine-protein kinase. (512 aa)
	LOC111154650	Tyrosine-protein kinase. (526 aa)
	LOC111157143	Tyrosine-protein kinase. (653 aa)
	LOC111157588	NFAT activation molecule 1. (261 aa)
	LOC111157715	Nck-associated protein 1-like isoform X1. (1145 aa)
	LOC111159177	Tyrosine-protein kinase. (686 aa)
	LOC111158187	B-cell antigen receptor complex-associated protein beta chain isoform X2. (227 aa)
	LOC111159680	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	LOC111162208	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	LOC111162308	B-lymphocyte antigen CD19 isoform X1. (568 aa)
	LOC111139538	B-cell antigen receptor complex-associated protein alpha chain. (193 aa)
	LOC111140995	Tyrosine-protein kinase. (620 aa)
	LOC111142837	Guanine nucleotide exchange factor VAV3. (847 aa)
	LOC111141942	Lck-interacting transmembrane adapter 1 isoform X1. (298 aa)
	LOC111141582	LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2. (912 aa)
	LOC111142759	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	LOC111143531	Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
	LOC111145558	MORN repeat-containing protein 5 isoform X2. (172 aa)
	LOC111145701	Linker for activation of T-cells family member 2 isoform X1. (233 aa)
	LOC111145374	B-cell linker protein isoform X1. (483 aa)
	LOC111146116	Tyrosine-protein kinase. (1149 aa)
	LOC111145176	Pleckstrin homology domain-containing family A member 1 isoform X1. (403 aa)
	LOC111145688	SH2B adapter protein 2 isoform X1. (639 aa)
	LOC111148794	Kelch-like protein 6. (621 aa)
	LOC111149008	Tyrosine-protein kinase. (652 aa)
	LOC111148445	Myocyte-specific enhancer factor 2C isoform X1. (483 aa)
	LOC111150935	Receptor-type tyrosine-protein phosphatase C isoform X1. (1298 aa)
	LOC111152853	Breast cancer anti-estrogen resistance protein 1 isoform X1. (890 aa)
	LOC111153538	Tyrosine-protein kinase. (635 aa)
	LOC111154657	Tyrosine-protein kinase. (398 aa)
	LOC111154956	Raftlin. (560 aa)
	LOC111152978	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111139538	LOC111142837	A0A2Y9IJV0	A0A2Y9IT49	B-cell antigen receptor complex-associated protein alpha chain.	Guanine nucleotide exchange factor VAV3.	0.463
LOC111139538	LOC111143531	A0A2Y9IJV0	A0A2Y9IWY4	B-cell antigen receptor complex-associated protein alpha chain.	Cytotoxic T-lymphocyte protein 4 isoform X1.	0.532
LOC111139538	LOC111145374	A0A2Y9IJV0	A0A2Y9J8C7	B-cell antigen receptor complex-associated protein alpha chain.	B-cell linker protein isoform X1.	0.854
LOC111139538	LOC111150935	A0A2Y9IJV0	A0A2Y9JTM5	B-cell antigen receptor complex-associated protein alpha chain.	Receptor-type tyrosine-protein phosphatase C isoform X1.	0.439
LOC111139538	LOC111152978	A0A2Y9IJV0	A0A2Y9KDH7	B-cell antigen receptor complex-associated protein alpha chain.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.621
LOC111139538	LOC111153538	A0A2Y9IJV0	A0A2Y9K4U3	B-cell antigen receptor complex-associated protein alpha chain.	Tyrosine-protein kinase.	0.825
LOC111139538	LOC111154650	A0A2Y9IJV0	A0A2Y9KLH9	B-cell antigen receptor complex-associated protein alpha chain.	Tyrosine-protein kinase.	0.558
LOC111139538	LOC111154657	A0A2Y9IJV0	A0A2Y9K8W6	B-cell antigen receptor complex-associated protein alpha chain.	Tyrosine-protein kinase.	0.558
LOC111139538	LOC111155370	A0A2Y9IJV0	A0A2Y9KDK4	B-cell antigen receptor complex-associated protein alpha chain.	Tyrosine-protein kinase.	0.965
LOC111139538	LOC111157143	A0A2Y9IJV0	A0A2Y9KLX9	B-cell antigen receptor complex-associated protein alpha chain.	Tyrosine-protein kinase.	0.427
LOC111139538	LOC111158187	A0A2Y9IJV0	A0A2Y9L2X2	B-cell antigen receptor complex-associated protein alpha chain.	B-cell antigen receptor complex-associated protein beta chain isoform X2.	0.999
LOC111139538	LOC111159177	A0A2Y9IJV0	A0A2Y9L177	B-cell antigen receptor complex-associated protein alpha chain.	Tyrosine-protein kinase.	0.702
LOC111139538	LOC111159680	A0A2Y9IJV0	A0A2Y9L924	B-cell antigen receptor complex-associated protein alpha chain.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.569
LOC111139538	LOC111162308	A0A2Y9IJV0	A0A2Y9LKU8	B-cell antigen receptor complex-associated protein alpha chain.	B-lymphocyte antigen CD19 isoform X1.	0.947
LOC111140995	LOC111142837	A0A2Y9ISR9	A0A2Y9IT49	Tyrosine-protein kinase.	Guanine nucleotide exchange factor VAV3.	0.956
LOC111140995	LOC111143531	A0A2Y9ISR9	A0A2Y9IWY4	Tyrosine-protein kinase.	Cytotoxic T-lymphocyte protein 4 isoform X1.	0.423
LOC111140995	LOC111145374	A0A2Y9ISR9	A0A2Y9J8C7	Tyrosine-protein kinase.	B-cell linker protein isoform X1.	0.445
LOC111140995	LOC111149008	A0A2Y9ISR9	A0A2Y9JLY6	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.945
LOC111140995	LOC111150935	A0A2Y9ISR9	A0A2Y9JTM5	Tyrosine-protein kinase.	Receptor-type tyrosine-protein phosphatase C isoform X1.	0.548
LOC111140995	LOC111152978	A0A2Y9ISR9	A0A2Y9KDH7	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.575