(34 nodes) Detection of mechanical stimulus network (Enhydra lutris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111142041	Glia-derived nexin; Belongs to the serpin family. (397 aa)
	LOC111141574	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin. (570 aa)
	LOC111141888	Transmembrane channel-like protein. (891 aa)
	LOC111141999	Phosphatidylinositol phosphatase PTPRQ. (2300 aa)
	LOC111141298	Polycystic kidney disease 2-like 2 protein isoform X1. (611 aa)
	LOC111142277	Leucine-rich repeat and IQ domain-containing protein 1. (1660 aa)
	LOC111142520	Piezo-type mechanosensitive ion channel component. (2756 aa)
	LOC111144224	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	LOC111145266	LOW QUALITY PROTEIN: polycystic kidney disease 2-like 1 protein. (855 aa)
	LOC111145682	Transmembrane protein 120A. (343 aa)
	LOC111146044	Whirlin isoform X1. (962 aa)
	LOC111145824	Pejvakin. (352 aa)
	LOC111146441	PHD finger protein 24. (400 aa)
	LOC111148912	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
	LOC111149622	Cysteine and glycine-rich protein 3. (194 aa)
	LOC111149997	Potassium channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (400 aa)
	LOC111149772	Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (667 aa)
	LOC111149311	Neuronal acetylcholine receptor subunit alpha-9. (479 aa)
	LOC111151683	Junction plakoglobin. (744 aa)
	LOC111151698	Telethonin isoform X1. (177 aa)
	LOC111152774	Piezo-type mechanosensitive ion channel component. (2510 aa)
	LOC111153064	LOW QUALITY PROTEIN: polycystic kidney disease protein 1-like 3. (1588 aa)
	LOC111153074	LOW QUALITY PROTEIN: polycystic kidney disease protein 1-like 2. (2449 aa)
	LOC111152458	Tetraspan membrane protein of hair cell stereocilia. (255 aa)
	LOC111153626	Transmembrane channel-like protein. (779 aa)
	LOC111154325	Acid-sensing ion channel 3 isoform X1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (578 aa)
	LOC111156789	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1369 aa)
	LOC111157012	Polycystic kidney disease protein 1-like 1. (812 aa)
	LOC111157013	Polycystic kidney disease protein 1-like 1. (1780 aa)
	LOC111157463	LOW QUALITY PROTEIN: polycystic kidney disease and receptor for egg jelly-related protein. (2169 aa)
	LOC111156258	Polycystin-1 isoform X3. (4310 aa)
	LOC111156195	Polycystin-2. (970 aa)
	LOC111159717	Stereocilin. (1772 aa)
	LOC111161519	Serine protease hepsin; Belongs to the peptidase S1 family. (417 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111141298	LOC111153064	A0A2Y9IQ48	A0A2Y9K274	Polycystic kidney disease 2-like 2 protein isoform X1.	LOW QUALITY PROTEIN: polycystic kidney disease protein 1-like 3.	0.491
LOC111141298	LOC111153074	A0A2Y9IQ48	A0A2Y9K2T2	Polycystic kidney disease 2-like 2 protein isoform X1.	LOW QUALITY PROTEIN: polycystic kidney disease protein 1-like 2.	0.491
LOC111141298	LOC111156258	A0A2Y9IQ48	A0A2Y9KN08	Polycystic kidney disease 2-like 2 protein isoform X1.	Polycystin-1 isoform X3.	0.619
LOC111141298	LOC111157463	A0A2Y9IQ48	A0A2Y9KLQ5	Polycystic kidney disease 2-like 2 protein isoform X1.	LOW QUALITY PROTEIN: polycystic kidney disease and receptor for egg jelly-related protein.	0.621
LOC111141888	LOC111142520	A0A2Y9IPK4	A0A2Y9ISG5	Transmembrane channel-like protein.	Piezo-type mechanosensitive ion channel component.	0.513
LOC111141888	LOC111145682	A0A2Y9IPK4	A0A2Y9J7B8	Transmembrane channel-like protein.	Transmembrane protein 120A.	0.641
LOC111141888	LOC111146044	A0A2Y9IPK4	A0A2Y9J833	Transmembrane channel-like protein.	Whirlin isoform X1.	0.722
LOC111141888	LOC111152458	A0A2Y9IPK4	A0A2Y9K4S0	Transmembrane channel-like protein.	Tetraspan membrane protein of hair cell stereocilia.	0.907
LOC111141888	LOC111152774	A0A2Y9IPK4	A0A2Y9K1S2	Transmembrane channel-like protein.	Piezo-type mechanosensitive ion channel component.	0.513
LOC111141888	LOC111153626	A0A2Y9IPK4	A0A2Y9K5U1	Transmembrane channel-like protein.	Transmembrane channel-like protein.	0.544
LOC111141888	LOC111159717	A0A2Y9IPK4	A0A2Y9L317	Transmembrane channel-like protein.	Stereocilin.	0.514
LOC111141999	LOC111159717	A0A2Y9IQ36	A0A2Y9L317	Phosphatidylinositol phosphatase PTPRQ.	Stereocilin.	0.471
LOC111142520	LOC111141888	A0A2Y9ISG5	A0A2Y9IPK4	Piezo-type mechanosensitive ion channel component.	Transmembrane channel-like protein.	0.513
LOC111142520	LOC111156789	A0A2Y9ISG5	A0A2Y9KIY7	Piezo-type mechanosensitive ion channel component.	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.445
LOC111144224	LOC111149622	A0A2Y9IZS5	A0A2Y9JN24	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Cysteine and glycine-rich protein 3.	0.564
LOC111144224	LOC111151683	A0A2Y9IZS5	A0A2Y9JX10	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Junction plakoglobin.	0.410
LOC111145266	LOC111153064	A0A2Y9J5F3	A0A2Y9K274	LOW QUALITY PROTEIN: polycystic kidney disease 2-like 1 protein.	LOW QUALITY PROTEIN: polycystic kidney disease protein 1-like 3.	0.989
LOC111145266	LOC111153074	A0A2Y9J5F3	A0A2Y9K2T2	LOW QUALITY PROTEIN: polycystic kidney disease 2-like 1 protein.	LOW QUALITY PROTEIN: polycystic kidney disease protein 1-like 2.	0.751
LOC111145266	LOC111156258	A0A2Y9J5F3	A0A2Y9KN08	LOW QUALITY PROTEIN: polycystic kidney disease 2-like 1 protein.	Polycystin-1 isoform X3.	0.832
LOC111145266	LOC111157012	A0A2Y9J5F3	A0A2Y9KJ70	LOW QUALITY PROTEIN: polycystic kidney disease 2-like 1 protein.	Polycystic kidney disease protein 1-like 1.	0.583