(35 nodes) Cardiac muscle cell development network (Enhydra lutris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111149378	Leucine-rich repeat-containing protein 10B. (292 aa)
	LOC111138934	Lamin isoform X1; Belongs to the intermediate filament family. (751 aa)
	LOC111141155	Delta-sarcoglycan. (289 aa)
	LOC111143391	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	LOC111141950	Leucine-rich repeat-containing protein 10. (307 aa)
	LOC111144224	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	LOC111144798	Nebulin-related-anchoring protein isoform X1. (1728 aa)
	LOC111144836	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
	LOC111144713	Alpha-actinin-2 isoform X2. (899 aa)
	LOC111147733	Serum response factor. (508 aa)
	LOC111148067	Bone morphogenetic protein 10. (424 aa)
	LOC111148565	Ankyrin repeat and SOCS box protein 2. (630 aa)
	LOC111147078	Protein ADP-ribosylarginine hydrolase-like protein 1. (354 aa)
	LOC111148924	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
	LOC111160061	LOW QUALITY PROTEIN: unconventional myosin-XVIIIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2549 aa)
	LOC111158319	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	LOC111158886	Mastermind-like protein 1. (1025 aa)
	LOC111158332	Blood vessel epicardial substance. (360 aa)
	LOC111155556	Nebulette isoform X1. (1013 aa)
	LOC111156507	T-box transcription factor TBX5. (518 aa)
	LOC111156410	T-box transcription factor TBX3 isoform X1. (744 aa)
	LOC111157401	Myosin light chain kinase 3 isoform X1. (807 aa)
	LOC111154273	Alpha-protein kinase 2. (2114 aa)
	LOC111154883	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	LOC111155930	Four and a half LIM domains protein 2. (279 aa)
	LOC111153272	Homeobox protein Nkx-2.6. (302 aa)
	LOC111152706	Alpha-protein kinase 3. (1658 aa)
	LOC111152562	Myocyte-specific enhancer factor 2A. (499 aa)
	LOC111151698	Telethonin isoform X1. (177 aa)
	LOC111151469	ADP-ribosylarginine hydrolase. (362 aa)
	LOC111150797	Prospero homeobox protein 1 isoform X1. (738 aa)
	LOC111150769	Heterogeneous nuclear ribonucleoprotein U isoform X1. (825 aa)
	LOC111149410	Coxsackievirus and adenovirus receptor. (365 aa)
	LOC111149725	Nebulin. (6429 aa)
	LOC111149622	Cysteine and glycine-rich protein 3. (194 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111138934	LOC111143391	A0A2Y9IE42	A0A2Y9IW89	Lamin isoform X1; Belongs to the intermediate filament family.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.587
LOC111138934	LOC111151698	A0A2Y9IE42	A0A2Y9JXI1	Lamin isoform X1; Belongs to the intermediate filament family.	Telethonin isoform X1.	0.526
LOC111141155	LOC111144224	A0A2Y9IPF5	A0A2Y9IZS5	Delta-sarcoglycan.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.474
LOC111143391	LOC111138934	A0A2Y9IW89	A0A2Y9IE42	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	Lamin isoform X1; Belongs to the intermediate filament family.	0.587
LOC111144224	LOC111141155	A0A2Y9IZS5	A0A2Y9IPF5	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Delta-sarcoglycan.	0.474
LOC111144224	LOC111144713	A0A2Y9IZS5	A0A2Y9JAQ2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Alpha-actinin-2 isoform X2.	0.401
LOC111144224	LOC111149622	A0A2Y9IZS5	A0A2Y9JN24	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Cysteine and glycine-rich protein 3.	0.564
LOC111144713	LOC111144224	A0A2Y9JAQ2	A0A2Y9IZS5	Alpha-actinin-2 isoform X2.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.401
LOC111144713	LOC111144798	A0A2Y9JAQ2	A0A2Y9J211	Alpha-actinin-2 isoform X2.	Nebulin-related-anchoring protein isoform X1.	0.479
LOC111144713	LOC111149622	A0A2Y9JAQ2	A0A2Y9JN24	Alpha-actinin-2 isoform X2.	Cysteine and glycine-rich protein 3.	0.679
LOC111144713	LOC111149725	A0A2Y9JAQ2	A0A2Y9JNM2	Alpha-actinin-2 isoform X2.	Nebulin.	0.588
LOC111144713	LOC111151698	A0A2Y9JAQ2	A0A2Y9JXI1	Alpha-actinin-2 isoform X2.	Telethonin isoform X1.	0.684
LOC111144713	LOC111155556	A0A2Y9JAQ2	A0A2Y9KQG5	Alpha-actinin-2 isoform X2.	Nebulette isoform X1.	0.533
LOC111144713	LOC111156507	A0A2Y9JAQ2	A0A2Y9KP97	Alpha-actinin-2 isoform X2.	T-box transcription factor TBX5.	0.496
LOC111144713	LOC111157401	A0A2Y9JAQ2	A0A2Y9KLG5	Alpha-actinin-2 isoform X2.	Myosin light chain kinase 3 isoform X1.	0.523
LOC111144713	LOC111160061	A0A2Y9JAQ2	A0A2Y9KZQ8	Alpha-actinin-2 isoform X2.	LOW QUALITY PROTEIN: unconventional myosin-XVIIIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.465
LOC111144798	LOC111144713	A0A2Y9J211	A0A2Y9JAQ2	Nebulin-related-anchoring protein isoform X1.	Alpha-actinin-2 isoform X2.	0.479
LOC111144798	LOC111149622	A0A2Y9J211	A0A2Y9JN24	Nebulin-related-anchoring protein isoform X1.	Cysteine and glycine-rich protein 3.	0.572
LOC111144798	LOC111151698	A0A2Y9J211	A0A2Y9JXI1	Nebulin-related-anchoring protein isoform X1.	Telethonin isoform X1.	0.689
LOC111144836	LOC111148067	A0A2Y9J3I8	A0A2Y9JGK5	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 10.	0.549