(72 nodes) Negative regulation of leukocyte proliferation network (Enhydra lutris)

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Predicted Interactions

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Your Input:
	LOC111153730	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
	LOC111153617	Programmed cell death 1 ligand 2 isoform X1. (288 aa)
	LOC111153609	Programmed cell death 1 ligand 1. (303 aa)
	LOC111152298	Leucine-rich repeat-containing protein 1. (524 aa)
	LOC111151749	B-cell lymphoma 6 protein. (706 aa)
	LOC111151595	Neurofibromin isoform X1. (2841 aa)
	LOC111151621	Galectin. (355 aa)
	LOC111151389	E3 ubiquitin-protein ligase MARCH7 isoform X1. (732 aa)
	LOC111151302	T-lymphocyte activation antigen CD80. (302 aa)
	LOC111151100	Interleukin-10. (178 aa)
	LOC111151024	Ras association domain-containing protein 5 isoform X1. (418 aa)
	LOC111150792	Roquin-1 isoform X1. (1131 aa)
	LOC111149664	LOW QUALITY PROTEIN: tetraspanin-32. (363 aa)
	LOC111150492	Forkhead box protein P3 isoform X1. (432 aa)
	LOC111149136	E3 ubiquitin-protein ligase CBL-B isoform X1. (980 aa)
	LOC111148534	Arginase. (354 aa)
	LOC111146525	Protein scribble homolog isoform X1. (1632 aa)
	LOC111138996	Zinc finger and BTB domain-containing protein 7B. (544 aa)
	LOC111139237	Tumor necrosis factor receptor superfamily member 13B-like. (157 aa)
	LOC111139325	V-set and immunoglobulin domain-containing protein 4 isoform X1. (399 aa)
	LOC111141415	E3 ubiquitin-protein ligase. (865 aa)
	LOC111139257	Tumor necrosis factor receptor superfamily member 13B-like. (262 aa)
	LOC111140644	Gremlin-1 isoform X1. (240 aa)
	LOC111141608	Major prion protein; Belongs to the prion family. (257 aa)
	LOC111141657	CCAAT/enhancer-binding protein. (346 aa)
	LOC111142254	PRKC apoptosis WT1 regulator protein. (340 aa)
	LOC111142519	Twisted gastrulation protein homolog 1. (223 aa)
	LOC111143333	Glomulin isoform X1. (600 aa)
	LOC111143531	Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
	LOC111144619	Indoleamine 2,3-dioxygenase 1. (354 aa)
	LOC111144778	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (388 aa)
	LOC111144670	V-type immunoglobulin domain-containing suppressor of T-cell activation. (311 aa)
	LOC111143582	V-set domain-containing T-cell activation inhibitor 1. (282 aa)
	LOC111145286	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	LOC111145738	Mitotic spindle assembly checkpoint protein MAD1 isoform X1. (717 aa)
	LOC111145168	Disks large homolog 5 isoform X1; Belongs to the MAGUK family. (1921 aa)
	LOC111145841	cAMP-dependent protein kinase type I-beta regulatory subunit. (377 aa)
	LOC111147314	Transmembrane glycoprotein NMB isoform X2. (558 aa)
	LOC111147510	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X1. (877 aa)
	LOC111147813	Tumor necrosis factor receptor superfamily member 21. (651 aa)
	LOC111148074	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
	LOC111159514	Leucine-rich repeat-containing protein 32. (663 aa)
	LOC111158090	cAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)
	LOC111160542	L-amino-acid oxidase isoform X1. (572 aa)
	LOC111159177	Tyrosine-protein kinase. (686 aa)
	LOC111160423	Forkhead box protein J1. (421 aa)
	LOC111158046	CMRF35-like molecule 8. (336 aa)
	LOC111161505	TYRO protein tyrosine kinase-binding protein isoform X1. (110 aa)
	LOC111161825	C-type lectin domain family 4 member G. (299 aa)
	LOC111162406	Serine/threonine-protein kinase N1 isoform X2. (956 aa)
	LOC111158621	Interleukin-2 receptor subunit alpha isoform X1. (275 aa)
	LOC111159680	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	LOC111161420	Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
	LOC111161524	Galectin. (139 aa)
	LOC111162047	Bone morphogenetic protein 4 isoform X1. (456 aa)
	LOC111154650	Tyrosine-protein kinase. (526 aa)
	LOC111154521	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (457 aa)
	LOC111156882	NEDD4 family-interacting protein 1. (221 aa)
	LOC111154869	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	LOC111154662	Tumor necrosis factor receptor superfamily member 14 isoform X1. (319 aa)
	LOC111155370	Tyrosine-protein kinase. (512 aa)
	LOC111155017	T-lymphocyte activation antigen CD86 isoform X1. (332 aa)
	LOC111155008	Interleukin-20 receptor subunit beta isoform X1. (294 aa)
	LOC111154927	Phospholipase A(2). (211 aa)
	LOC111155042	Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
	LOC111153576	Transmembrane protein 131-like isoform X1. (1609 aa)
	LOC111154393	Disks large homolog 2 isoform X1. (919 aa)
	LOC111154657	Tyrosine-protein kinase. (398 aa)
	LOC111153162	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1186 aa)
	LOC111154042	Transcription factor SOX. (453 aa)
	LOC111153927	Cytotoxic and regulatory T-cell molecule. (393 aa)
	LOC111152822	Transmembrane protein 131-like. (516 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111139237	LOC111139257	A0A2Y9IIU2	A0A2Y9IM99	Tumor necrosis factor receptor superfamily member 13B-like.	Tumor necrosis factor receptor superfamily member 13B-like.	0.900
LOC111139257	LOC111139237	A0A2Y9IM99	A0A2Y9IIU2	Tumor necrosis factor receptor superfamily member 13B-like.	Tumor necrosis factor receptor superfamily member 13B-like.	0.900
LOC111140644	LOC111162047	A0A2Y9IMH2	A0A2Y9LJR5	Gremlin-1 isoform X1.	Bone morphogenetic protein 4 isoform X1.	0.700
LOC111141415	LOC111144778	A0A2Y9ILU8	A0A2Y9J259	E3 ubiquitin-protein ligase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.621
LOC111141415	LOC111151024	A0A2Y9ILU8	A0A2Y9JTY4	E3 ubiquitin-protein ligase.	Ras association domain-containing protein 5 isoform X1.	0.574
LOC111141415	LOC111156882	A0A2Y9ILU8	A0A2Y9KIM5	E3 ubiquitin-protein ligase.	NEDD4 family-interacting protein 1.	0.465
LOC111142519	LOC111162047	A0A2Y9IRW9	A0A2Y9LJR5	Twisted gastrulation protein homolog 1.	Bone morphogenetic protein 4 isoform X1.	0.459
LOC111143531	LOC111143582	A0A2Y9IWY4	A0A2Y9J4Y3	Cytotoxic T-lymphocyte protein 4 isoform X1.	V-set domain-containing T-cell activation inhibitor 1.	0.523
LOC111143531	LOC111144619	A0A2Y9IWY4	A0A2Y9J1A4	Cytotoxic T-lymphocyte protein 4 isoform X1.	Indoleamine 2,3-dioxygenase 1.	0.552
LOC111143531	LOC111144670	A0A2Y9IWY4	A0A2Y9J4Y2	Cytotoxic T-lymphocyte protein 4 isoform X1.	V-type immunoglobulin domain-containing suppressor of T-cell activation.	0.424
LOC111143531	LOC111150492	A0A2Y9IWY4	A0A2Y9JRM6	Cytotoxic T-lymphocyte protein 4 isoform X1.	Forkhead box protein P3 isoform X1.	0.779
LOC111143531	LOC111151100	A0A2Y9IWY4	A0A2Y9JUC2	Cytotoxic T-lymphocyte protein 4 isoform X1.	Interleukin-10.	0.686
LOC111143531	LOC111151302	A0A2Y9IWY4	A0A2Y9JV96	Cytotoxic T-lymphocyte protein 4 isoform X1.	T-lymphocyte activation antigen CD80.	0.999
LOC111143531	LOC111151621	A0A2Y9IWY4	A0A2Y9JWD6	Cytotoxic T-lymphocyte protein 4 isoform X1.	Galectin.	0.611
LOC111143531	LOC111151749	A0A2Y9IWY4	A0A2Y9JWY2	Cytotoxic T-lymphocyte protein 4 isoform X1.	B-cell lymphoma 6 protein.	0.648
LOC111143531	LOC111153609	A0A2Y9IWY4	A0A2Y9K4G6	Cytotoxic T-lymphocyte protein 4 isoform X1.	Programmed cell death 1 ligand 1.	0.877
LOC111143531	LOC111153617	A0A2Y9IWY4	A0A2Y9K577	Cytotoxic T-lymphocyte protein 4 isoform X1.	Programmed cell death 1 ligand 2 isoform X1.	0.547
LOC111143531	LOC111154869	A0A2Y9IWY4	A0A2Y9KGA6	Cytotoxic T-lymphocyte protein 4 isoform X1.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.701
LOC111143531	LOC111155017	A0A2Y9IWY4	A0A2Y9KC61	Cytotoxic T-lymphocyte protein 4 isoform X1.	T-lymphocyte activation antigen CD86 isoform X1.	0.999
LOC111143531	LOC111155370	A0A2Y9IWY4	A0A2Y9KDK4	Cytotoxic T-lymphocyte protein 4 isoform X1.	Tyrosine-protein kinase.	0.469