(7 nodes) Gamma-secretase complex network (Enhydra lutris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111153322	Gamma-secretase subunit APH-1B isoform X1. (257 aa)
	LOC111148703	Transmembrane emp24 domain-containing protein 10. (219 aa)
	LOC111148789	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
	LOC111138884	Nicastrin isoform X1. (709 aa)
	LOC111161372	Gamma-secretase subunit PEN-2. (101 aa)
	LOC111162023	Gamma-secretase subunit APH-1A isoform X1. (342 aa)
	LOC111150660	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (515 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111138884	LOC111148703	A0A2Y9IH76	A0A2Y9JTV8	Nicastrin isoform X1.	Transmembrane emp24 domain-containing protein 10.	0.560
LOC111138884	LOC111148789	A0A2Y9IH76	A0A2Y9JP29	Nicastrin isoform X1.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.999
LOC111138884	LOC111150660	A0A2Y9IH76	A0A2Y9K2F5	Nicastrin isoform X1.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.999
LOC111138884	LOC111153322	A0A2Y9IH76	A0A2Y9K3X7	Nicastrin isoform X1.	Gamma-secretase subunit APH-1B isoform X1.	0.995
LOC111138884	LOC111161372	A0A2Y9IH76	A0A2Y9LAS0	Nicastrin isoform X1.	Gamma-secretase subunit PEN-2.	0.999
LOC111138884	LOC111162023	A0A2Y9IH76	A0A2Y9L996	Nicastrin isoform X1.	Gamma-secretase subunit APH-1A isoform X1.	0.995
LOC111148703	LOC111138884	A0A2Y9JTV8	A0A2Y9IH76	Transmembrane emp24 domain-containing protein 10.	Nicastrin isoform X1.	0.560
LOC111148703	LOC111161372	A0A2Y9JTV8	A0A2Y9LAS0	Transmembrane emp24 domain-containing protein 10.	Gamma-secretase subunit PEN-2.	0.540
LOC111148789	LOC111138884	A0A2Y9JP29	A0A2Y9IH76	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Nicastrin isoform X1.	0.999
LOC111148789	LOC111150660	A0A2Y9JP29	A0A2Y9K2F5	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.999
LOC111148789	LOC111153322	A0A2Y9JP29	A0A2Y9K3X7	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Gamma-secretase subunit APH-1B isoform X1.	0.993
LOC111148789	LOC111161372	A0A2Y9JP29	A0A2Y9LAS0	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Gamma-secretase subunit PEN-2.	0.999
LOC111148789	LOC111162023	A0A2Y9JP29	A0A2Y9L996	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Gamma-secretase subunit APH-1A isoform X1.	0.990
LOC111150660	LOC111138884	A0A2Y9K2F5	A0A2Y9IH76	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Nicastrin isoform X1.	0.999
LOC111150660	LOC111148789	A0A2Y9K2F5	A0A2Y9JP29	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.999
LOC111150660	LOC111153322	A0A2Y9K2F5	A0A2Y9K3X7	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Gamma-secretase subunit APH-1B isoform X1.	0.993
LOC111150660	LOC111161372	A0A2Y9K2F5	A0A2Y9LAS0	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Gamma-secretase subunit PEN-2.	0.999
LOC111150660	LOC111162023	A0A2Y9K2F5	A0A2Y9L996	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Gamma-secretase subunit APH-1A isoform X1.	0.988
LOC111153322	LOC111138884	A0A2Y9K3X7	A0A2Y9IH76	Gamma-secretase subunit APH-1B isoform X1.	Nicastrin isoform X1.	0.995
LOC111153322	LOC111148789	A0A2Y9K3X7	A0A2Y9JP29	Gamma-secretase subunit APH-1B isoform X1.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.993