48 items (Enhydra lutris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111162572	Gamma-aminobutyric acid type B receptor subunit 1 isoform X1. (1024 aa)
	LOC111161670	LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase S. (1909 aa)
	LOC111162323	Voltage-dependent calcium channel gamma-3 subunit. (315 aa)
	LOC111162338	Germ cell-specific gene 1-like protein isoform X1. (348 aa)
	LOC111160608	LOW QUALITY PROTEIN: SH3 and multiple ankyrin repeat domains protein 1. (2170 aa)
	LOC111160439	Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1. (534 aa)
	LOC111157054	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1138 aa)
	LOC111158132	MAGUK p55 subfamily member 2 isoform X1; Belongs to the MAGUK family. (569 aa)
	LOC111158695	A-kinase anchor protein 12. (1749 aa)
	LOC111157906	General receptor for phosphoinositides 1-associated scaffold protein isoform X1. (393 aa)
	LOC111157697	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
	LOC111156654	Dysbindin. (342 aa)
	LOC111155116	Neurofilament light polypeptide; Belongs to the intermediate filament family. (544 aa)
	LOC111154625	Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
	LOC111155558	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	LOC111153632	Amyloid beta A4 precursor protein-binding family A member 1. (837 aa)
	LOC111154566	Serine/threonine-protein phosphatase. (521 aa)
	LOC111151963	Diacylglycerol kinase. (1058 aa)
	LOC111154498	Metabotropic glutamate receptor 5. (1216 aa)
	LOC111153205	Neuroplastin. (361 aa)
	LOC111152031	Leucine-rich repeat-containing protein 4. (650 aa)
	LOC111152935	Cadherin-11; Cadherins are calcium-dependent cell adhesion proteins. (796 aa)
	LOC111150081	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
	LOC111151620	F-box/LRR-repeat protein 20. (438 aa)
	LOC111150683	tenascin-R. (1358 aa)
	LOC111151499	Profilin; Belongs to the profilin family. (140 aa)
	LOC111149995	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
	LOC111150752	Ephrin type-A receptor 4. (987 aa)
	LOC111150487	Synaptophysin. (313 aa)
	LOC111150078	Leucine-rich repeat-containing protein 4C. (640 aa)
	LOC111148007	Calcineurin subunit B type 1. (170 aa)
	LOC111150120	Syntaxin-3; Belongs to the syntaxin family. (289 aa)
	LOC111147676	Metabotropic glutamate receptor 1 isoform X1. (1190 aa)
	LOC111147836	Leucine-rich repeat and fibronectin type-III domain-containing protein 2. (792 aa)
	LOC111147309	Diacylglycerol kinase. (803 aa)
	LOC111146667	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
	LOC111146053	Calcineurin subunit B type 2. (170 aa)
	LOC111145308	Alpha-internexin; Belongs to the intermediate filament family. (500 aa)
	LOC111144005	Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
	LOC111145807	netrin-G2 isoform X1. (642 aa)
	LOC111144489	Plasminogen activator; Belongs to the peptidase S1 family. (560 aa)
	LOC111144357	LOW QUALITY PROTEIN: protein bassoon. (3916 aa)
	LOC111142593	Breakpoint cluster region protein isoform X1. (1282 aa)
	LOC111143062	netrin-G1 isoform X1. (539 aa)
	LOC111142604	Netrin receptor DCC. (1396 aa)
	LOC111141437	Receptor-type tyrosine-protein phosphatase alpha. (801 aa)
	LOC111141423	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
	LOC111139804	IQ motif and SEC7 domain-containing protein 2 isoform X1. (1526 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111141423	LOC111142604	A0A2Y9IM88	A0A2Y9IS99	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Netrin receptor DCC.	0.914
LOC111141423	LOC111144005	A0A2Y9IM88	A0A2Y9J7B5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Inositol 1,4,5-trisphosphate receptor type 1 isoform X1.	0.928
LOC111141423	LOC111146053	A0A2Y9IM88	A0A2Y9J840	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Calcineurin subunit B type 2.	0.900
LOC111141423	LOC111147309	A0A2Y9IM88	A0A2Y9JEH3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Diacylglycerol kinase.	0.692
LOC111141423	LOC111148007	A0A2Y9IM88	A0A2Y9JQG7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Calcineurin subunit B type 1.	0.900
LOC111141423	LOC111151963	A0A2Y9IM88	A0A2Y9K8U9	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Diacylglycerol kinase.	0.676
LOC111141423	LOC111154566	A0A2Y9IM88	A0A2Y9K915	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Serine/threonine-protein phosphatase.	0.928
LOC111142604	LOC111141423	A0A2Y9IS99	A0A2Y9IM88	Netrin receptor DCC.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.914
LOC111142604	LOC111143062	A0A2Y9IS99	A0A2Y9IV27	Netrin receptor DCC.	netrin-G1 isoform X1.	0.646
LOC111142604	LOC111145807	A0A2Y9IS99	A0A2Y9J724	Netrin receptor DCC.	netrin-G2 isoform X1.	0.607
LOC111143062	LOC111142604	A0A2Y9IV27	A0A2Y9IS99	netrin-G1 isoform X1.	Netrin receptor DCC.	0.646
LOC111143062	LOC111150078	A0A2Y9IV27	A0A2Y9JR28	netrin-G1 isoform X1.	Leucine-rich repeat-containing protein 4C.	0.997
LOC111143062	LOC111152031	A0A2Y9IV27	A0A2Y9K2T6	netrin-G1 isoform X1.	Leucine-rich repeat-containing protein 4.	0.648
LOC111144005	LOC111141423	A0A2Y9J7B5	A0A2Y9IM88	Inositol 1,4,5-trisphosphate receptor type 1 isoform X1.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.928
LOC111144005	LOC111147676	A0A2Y9J7B5	A0A2Y9JP60	Inositol 1,4,5-trisphosphate receptor type 1 isoform X1.	Metabotropic glutamate receptor 1 isoform X1.	0.452
LOC111145308	LOC111155116	A0A2Y9J837	A0A2Y9KHE1	Alpha-internexin; Belongs to the intermediate filament family.	Neurofilament light polypeptide; Belongs to the intermediate filament family.	0.882
LOC111145807	LOC111142604	A0A2Y9J724	A0A2Y9IS99	netrin-G2 isoform X1.	Netrin receptor DCC.	0.607
LOC111145807	LOC111150078	A0A2Y9J724	A0A2Y9JR28	netrin-G2 isoform X1.	Leucine-rich repeat-containing protein 4C.	0.526
LOC111145807	LOC111152031	A0A2Y9J724	A0A2Y9K2T6	netrin-G2 isoform X1.	Leucine-rich repeat-containing protein 4.	0.986
LOC111146053	LOC111141423	A0A2Y9J840	A0A2Y9IM88	Calcineurin subunit B type 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.900