(54 nodes) RNA polymerase II, holoenzyme network (Enhydra lutris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111149658	DNA-directed RNA polymerase II subunit RPB7. (172 aa)
	LOC111142522	Transcription initiation factor TFIID subunit 4B isoform X2. (868 aa)
	LOC111142439	Regulation of nuclear pre-mRNA domain-containing protein 1A isoform X1. (312 aa)
	LOC111143297	Transcription initiation factor TFIID subunit 12 isoform X1. (213 aa)
	LOC111143170	Transcription initiation factor TFIID subunit 13. (124 aa)
	LOC111143332	Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2. (611 aa)
	LOC111141768	Regulation of nuclear pre-mRNA domain-containing protein 1B isoform X1. (326 aa)
	LOC111143236	WD repeat-containing protein 47 isoform X1. (920 aa)
	LOC111144455	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (291 aa)
	LOC111145930	Uroplakin-3b-like protein 1. (266 aa)
	LOC111145948	DNA-directed RNA polymerase II subunit RPB11-a isoform X1. (128 aa)
	LOC111146579	Transcription initiation factor TFIID subunit 2 isoform X1. (1251 aa)
	LOC111147172	General transcription factor IIF subunit 2. (251 aa)
	LOC111147490	DNA-directed RNA polymerases I, II, and III subunit RPABC5-like. (86 aa)
	LOC111147563	Transcription initiation protein SPT3 homolog isoform X1. (377 aa)
	LOC111145838	DNA-directed RNA polymerase II subunit RPB11-a-like. (133 aa)
	LOC111148194	DNA-directed RNA polymerases I, II, and III subunit RPABC5-like. (67 aa)
	LOC111148288	cyclin-H isoform X1; Belongs to the cyclin family. (328 aa)
	LOC111148654	Transcription initiation factor IIA subunit 1. (376 aa)
	LOC111148083	TFIIA-alpha and beta-like factor isoform X1. (477 aa)
	LOC111148672	Cyclin-dependent kinase 2-interacting protein. (212 aa)
	LOC111147854	Transcription initiation factor TFIID subunit 8 isoform X1. (310 aa)
	LOC111150095	DNA-directed RNA polymerases I, II, and III subunit RPABC5. (67 aa)
	LOC111149996	General transcription factor IIH subunit 1. (547 aa)
	LOC111151037	Parafibromin. (531 aa)
	LOC111149041	General transcription factor IIE subunit 1. (438 aa)
	LOC111152186	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (508 aa)
	LOC111153176	Protein GRINL1A isoform X1. (368 aa)
	LOC111153352	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
	LOC111152673	WD repeat-containing protein 61 isoform X1. (305 aa)
	LOC111155330	General transcription factor IIH subunit. (435 aa)
	LOC111155444	Transcription elongation factor A protein 1. (301 aa)
	LOC111156484	General transcription factor IIH subunit 3 isoform X1. (309 aa)
	LOC111156806	Peroxisome biogenesis factor 2 isoform X1. (328 aa)
	LOC111155210	Cyclin-dependent kinase 7 isoform X1; Belongs to the protein kinase superfamily. (354 aa)
	LOC111157687	DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1. (130 aa)
	LOC111158610	Transcription initiation factor TFIID subunit 3. (930 aa)
	LOC111160264	ATP-dependent DNA helicase Q5-like. (342 aa)
	LOC111158693	General transcription factor IIH subunit 5. (71 aa)
	LOC111160532	Transcription initiation factor TFIID subunit 5. (589 aa)
	LOC111161378	RNA polymerase II-associated factor 1 homolog isoform X2. (536 aa)
	LOC111161337	RNA polymerase-associated protein RTF1 homolog. (710 aa)
	LOC111161572	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
	LOC111161737	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (518 aa)
	LOC111160317	ATP-dependent DNA helicase Q5-like isoform X1. (1011 aa)
	LOC111161893	DNA-directed RNA polymerases I, II, and III subunit RPABC1. (210 aa)
	LOC111159484	RNA polymerase-associated protein CTR9 homolog isoform X1. (1173 aa)
	LOC111160876	TFIIH basal transcription factor complex helicase XPB subunit. (782 aa)
	LOC111161373	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
	LOC111160609	RNA polymerase-associated protein LEO1 isoform X1. (665 aa)
	LOC111161044	Transcription initiation factor TFIID subunit. (1905 aa)
	LOC111140117	RNA polymerase-associated protein LEO1-like. (298 aa)
	LOC111139633	SH3 domain-binding protein 5-like. (385 aa)
	LOC111141505	Transcription initiation factor TFIID subunit 4. (1058 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111140117	LOC111145838	A0A2Y9IIW4	A0A2Y9JGB7	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerase II subunit RPB11-a-like.	0.714
LOC111140117	LOC111145930	A0A2Y9IIW4	A0A2Y9J7M4	RNA polymerase-associated protein LEO1-like.	Uroplakin-3b-like protein 1.	0.714
LOC111140117	LOC111145948	A0A2Y9IIW4	A0A2Y9J8Q0	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerase II subunit RPB11-a isoform X1.	0.714
LOC111140117	LOC111147490	A0A2Y9IIW4	A0A2Y9JDY0	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerases I, II, and III subunit RPABC5-like.	0.739
LOC111140117	LOC111148194	A0A2Y9IIW4	A0A2Y9JH79	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerases I, II, and III subunit RPABC5-like.	0.739
LOC111140117	LOC111148672	A0A2Y9IIW4	A0A2Y9JNI2	RNA polymerase-associated protein LEO1-like.	Cyclin-dependent kinase 2-interacting protein.	0.994
LOC111140117	LOC111149658	A0A2Y9IIW4	A0A2Y9JYD0	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerase II subunit RPB7.	0.972
LOC111140117	LOC111150095	A0A2Y9IIW4	A0A2Y9JQ60	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerases I, II, and III subunit RPABC5.	0.739
LOC111140117	LOC111151037	A0A2Y9IIW4	A0A2Y9JTS6	RNA polymerase-associated protein LEO1-like.	Parafibromin.	0.999
LOC111140117	LOC111152673	A0A2Y9IIW4	A0A2Y9K5I6	RNA polymerase-associated protein LEO1-like.	WD repeat-containing protein 61 isoform X1.	0.968
LOC111140117	LOC111155444	A0A2Y9IIW4	A0A2Y9KDU6	RNA polymerase-associated protein LEO1-like.	Transcription elongation factor A protein 1.	0.617
LOC111140117	LOC111157687	A0A2Y9IIW4	A0A2Y9KPL2	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1.	0.969
LOC111140117	LOC111159484	A0A2Y9IIW4	A0A2Y9L8C4	RNA polymerase-associated protein LEO1-like.	RNA polymerase-associated protein CTR9 homolog isoform X1.	0.997
LOC111140117	LOC111161337	A0A2Y9IIW4	A0A2Y9L424	RNA polymerase-associated protein LEO1-like.	RNA polymerase-associated protein RTF1 homolog.	0.996
LOC111140117	LOC111161378	A0A2Y9IIW4	A0A2Y9L395	RNA polymerase-associated protein LEO1-like.	RNA polymerase II-associated factor 1 homolog isoform X2.	0.998
LOC111140117	LOC111161572	A0A2Y9IIW4	A0A2Y9L469	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.971
LOC111140117	LOC111161893	A0A2Y9IIW4	A0A2Y9L6P4	RNA polymerase-associated protein LEO1-like.	DNA-directed RNA polymerases I, II, and III subunit RPABC1.	0.967
LOC111141505	LOC111142522	A0A2Y9INQ0	A0A2Y9IRX3	Transcription initiation factor TFIID subunit 4.	Transcription initiation factor TFIID subunit 4B isoform X2.	0.989
LOC111141505	LOC111143170	A0A2Y9INQ0	A0A2Y9IVL0	Transcription initiation factor TFIID subunit 4.	Transcription initiation factor TFIID subunit 13.	0.968
LOC111141505	LOC111143297	A0A2Y9INQ0	A0A2Y9IVI2	Transcription initiation factor TFIID subunit 4.	Transcription initiation factor TFIID subunit 12 isoform X1.	0.999