(101 nodes) EGF-like calcium-binding, conserved site network (Enhydra lutris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111158391	LOW QUALITY PROTEIN: fibulin-7. (577 aa)
	LOC111141989	Low-density lipoprotein receptor-related protein 2. (4705 aa)
	LOC111141662	Thrombomodulin. (567 aa)
	LOC111141735	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	LOC111140884	Low-density lipoprotein receptor-related protein 1B. (4692 aa)
	LOC111139020	LOW QUALITY PROTEIN: thrombospondin-3. (956 aa)
	LOC111140889	Fibrillin-2. (2910 aa)
	LOC111139506	LOW QUALITY PROTEIN: multiple epidermal growth factor-like domains protein 8. (2799 aa)
	LOC111140918	Slit homolog 3 protein isoform X1. (1538 aa)
	LOC111145146	Cartilage acidic protein 1. (435 aa)
	LOC111144008	Cartilage oligomeric matrix protein. (756 aa)
	LOC111144239	Cysteine-rich with EGF-like domain protein 1 isoform X1. (420 aa)
	LOC111144249	Neurocan core protein. (1335 aa)
	LOC111146187	Hemicentin-2. (5031 aa)
	LOC111145699	Sushi domain-containing protein 1. (746 aa)
	LOC111145837	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1. (3574 aa)
	LOC111145231	Oncoprotein-induced transcript 3 protein. (546 aa)
	LOC111146397	Epidermal growth factor-like protein 7 isoform X1. (351 aa)
	LOC111147427	Von Willebrand factor D and EGF domain-containing protein isoform X1. (1771 aa)
	LOC111145671	Neurogenic locus notch homolog protein 1. (2562 aa)
	LOC111147090	Growth arrest-specific protein 6 isoform X1. (674 aa)
	LOC111148014	EGF-containing fibulin-like extracellular matrix protein 1. (502 aa)
	LOC111147145	Coagulation factor VII isoform X3. (457 aa)
	LOC111147791	Protein delta homolog 2. (383 aa)
	LOC111148314	EGF-like repeat and discoidin I-like domain-containing protein 3 isoform X1. (480 aa)
	LOC111146321	Protein crumbs homolog 2. (1284 aa)
	LOC111148597	Fibulin-5. (448 aa)
	LOC111148619	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa)
	LOC111146998	Coagulation factor X isoform X1. (485 aa)
	LOC111148756	Latent-transforming growth factor beta-binding protein 2. (1816 aa)
	LOC111145202	Metalloendopeptidase. (1021 aa)
	LOC111162484	CD97 antigen-like. (309 aa)
	LOC111162483	Adhesion G protein-coupled receptor E2-like; Belongs to the G-protein coupled receptor 2 family. (794 aa)
	LOC111162536	LOW QUALITY PROTEIN: adhesion G protein-coupled receptor E2; Belongs to the G-protein coupled receptor 2 family. (768 aa)
	LOC111162438	Low-density lipoprotein receptor. (839 aa)
	LOC111160101	Prolow-density lipoprotein receptor-related protein 1. (4544 aa)
	LOC111162535	CD97 antigen isoform X1; Belongs to the G-protein coupled receptor 2 family. (835 aa)
	LOC111162157	Nidogen-2. (1369 aa)
	LOC111159361	Signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1. (1000 aa)
	LOC111161493	Latent-transforming growth factor beta-binding protein 4 isoform X1. (1619 aa)
	LOC111161745	Fibrillin-3 isoform X1. (2858 aa)
	LOC111161644	Adhesion G protein-coupled receptor E1; Belongs to the G-protein coupled receptor 2 family. (938 aa)
	LOC111161722	Putative adhesion G protein-coupled receptor E4P; Belongs to the G-protein coupled receptor 2 family. (654 aa)
	LOC111159747	Complement C1s subcomponent; Belongs to the peptidase S1 family. (695 aa)
	LOC111160850	Vitamin K-dependent protein C isoform X1. (513 aa)
	LOC111160478	Nidogen-1. (1237 aa)
	LOC111158683	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (743 aa)
	LOC111156717	Metalloendopeptidase. (989 aa)
	LOC111149403	Latent-transforming growth factor beta-binding protein 3 isoform X1. (1302 aa)
	LOC111149667	LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 4. (1961 aa)
	LOC111149698	EGF-containing fibulin-like extracellular matrix protein 2. (443 aa)
	LOC111149581	EGF-like and EMI domain-containing protein 1. (585 aa)
	LOC111148875	Vitamin K-dependent protein S. (675 aa)
	LOC111149686	Protein kinase C-binding protein NELL1 isoform X1. (810 aa)
	LOC111147948	Mannan-binding lectin serine protease 1 isoform X1; Belongs to the peptidase S1 family. (728 aa)
	LOC111150053	LOW QUALITY PROTEIN: von Willebrand factor C and EGF domain-containing protein. (931 aa)
	LOC111148277	LOW QUALITY PROTEIN: thrombospondin-4. (964 aa)
	LOC111148298	Versican core protein. (3404 aa)
	LOC111150763	Hemicentin-1. (5635 aa)
	LOC111148955	Slit homolog 2 protein isoform X1. (1530 aa)
	LOC111152227	LOW QUALITY PROTEIN: protein eyes shut homolog. (3144 aa)
	LOC111152303	Signal peptide, CUB and EGF-like domain-containing protein 3 isoform X1. (993 aa)
	LOC111152217	Epidermal growth factor-like protein 8 isoform X1. (382 aa)
	LOC111150010	Endosialin. (771 aa)
	LOC111152552	Aggrecan core protein. (1904 aa)
	LOC111152233	Neurogenic locus notch homolog protein 4 isoform X1. (1994 aa)
	LOC111151161	Protein crumbs homolog 1 isoform X1. (1336 aa)
	LOC111153544	Very low-density lipoprotein receptor isoform X1. (873 aa)
	LOC111154148	Thyroid peroxidase. (1524 aa)
	LOC111154480	Protocadherin Fat 3. (4557 aa)
	LOC111154294	Collagen and calcium-binding EGF domain-containing protein 1. (407 aa)
	LOC111154710	Mannan-binding lectin serine protease 2; Belongs to the peptidase S1 family. (686 aa)
	LOC111154767	Multiple epidermal growth factor-like domains protein 6 isoform X1. (1801 aa)
	LOC111154837	Mannan-binding lectin serine protease 2-like; Belongs to the peptidase S1 family. (554 aa)
	LOC111155190	Protein HEG homolog 1 isoform X1. (1385 aa)
	LOC111155560	Cubilin. (3619 aa)
	LOC111156007	Uromodulin. (643 aa)
	LOC111156114	Metalloendopeptidase. (1012 aa)
	LOC111155676	Uromodulin-like 1. (1355 aa)
	LOC111157164	Epidermal growth factor-like protein 6 isoform X1. (609 aa)
	LOC111156127	Protocadherin Fat 4 isoform X2. (4982 aa)
	LOC111157818	Protein kinase C-binding protein NELL2. (816 aa)
	LOC111157667	Signal peptide, CUB and EGF-like domain-containing protein 1 isoform X1. (1018 aa)
	LOC111159057	Fibulin-2. (1226 aa)
	LOC111159719	Complement C1r subcomponent; Belongs to the peptidase S1 family. (705 aa)
	LOC111156359	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
	LOC111157524	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (674 aa)
	LOC111158675	Fibrillin-1. (2871 aa)
	LOC111158974	Coagulation factor IX isoform X1. (459 aa)
	LOC111157263	Nephronectin isoform X1. (614 aa)
	LOC111158428	Latent-transforming growth factor beta-binding protein 1 isoform X1. (1718 aa)
	LOC111142867	Neurogenic locus notch homolog protein 2. (2471 aa)
	LOC111157659	Cysteine-rich with EGF-like domain protein 2 isoform X1. (464 aa)
	LOC111145172	Sushi, nidogen and EGF-like domain-containing protein 1 isoform X1. (1382 aa)
	LOC111144820	Slit homolog 1 protein. (1534 aa)
	LOC111144511	Protocadherin Fat 1. (4588 aa)
	LOC111143680	Delta and Notch-like epidermal growth factor-related receptor. (740 aa)
	LOC111143932	Neurogenic locus notch homolog protein 3. (2322 aa)
	LOC111143169	Adhesion G protein-coupled receptor L4 isoform X1; Belongs to the G-protein coupled receptor 2 family. (695 aa)
	LOC111143036	Low-density lipoprotein receptor-related protein 8 isoform X1. (965 aa)
	LOC111141824	Complement component C1q receptor. (646 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111139020	LOC111144008	A0A2Y9ILB8	A0A2Y9J7C0	LOW QUALITY PROTEIN: thrombospondin-3.	Cartilage oligomeric matrix protein.	0.426
LOC111139020	LOC111148277	A0A2Y9ILB8	A0A2Y9JRL9	LOW QUALITY PROTEIN: thrombospondin-3.	LOW QUALITY PROTEIN: thrombospondin-4.	0.467
LOC111139020	LOC111152552	A0A2Y9ILB8	A0A2Y9K0A5	LOW QUALITY PROTEIN: thrombospondin-3.	Aggrecan core protein.	0.530
LOC111140889	LOC111158675	A0A2Y9IKT0	A0A2Y9KTV2	Fibrillin-2.	Fibrillin-1.	0.574
LOC111141662	LOC111146998	A0A2Y9IPG6	A0A2Y9JKZ6	Thrombomodulin.	Coagulation factor X isoform X1.	0.604
LOC111141662	LOC111147145	A0A2Y9IPG6	A0A2Y9JGH5	Thrombomodulin.	Coagulation factor VII isoform X3.	0.530
LOC111141662	LOC111160850	A0A2Y9IPG6	A0A2Y9L210	Thrombomodulin.	Vitamin K-dependent protein C isoform X1.	0.973
LOC111141735	LOC111142867	A0A2Y9INZ5	A0A2Y9ITD4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 2.	0.991
LOC111141735	LOC111143932	A0A2Y9INZ5	A0A2Y9IZ80	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 3.	0.994
LOC111141735	LOC111145671	A0A2Y9INZ5	A0A2Y9JFB7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 1.	0.998
LOC111141735	LOC111148619	A0A2Y9INZ5	A0A2Y9JKC6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.959
LOC111141735	LOC111152227	A0A2Y9INZ5	A0A2Y9JYX8	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	LOW QUALITY PROTEIN: protein eyes shut homolog.	0.662
LOC111141735	LOC111152233	A0A2Y9INZ5	A0A2Y9K3Y3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 4 isoform X1.	0.990
LOC111141735	LOC111156359	A0A2Y9INZ5	A0A2Y9KUK6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.457
LOC111141735	LOC111158683	A0A2Y9INZ5	A0A2Y9KZ31	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.456
LOC111141989	LOC111153544	A0A2Y9IQ17	A0A2Y9K5E6	Low-density lipoprotein receptor-related protein 2.	Very low-density lipoprotein receptor isoform X1.	0.419
LOC111141989	LOC111155560	A0A2Y9IQ17	A0A2Y9KEB0	Low-density lipoprotein receptor-related protein 2.	Cubilin.	0.799
LOC111141989	LOC111156007	A0A2Y9IQ17	A0A2Y9KGG6	Low-density lipoprotein receptor-related protein 2.	Uromodulin.	0.523
LOC111141989	LOC111156359	A0A2Y9IQ17	A0A2Y9KUK6	Low-density lipoprotein receptor-related protein 2.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.460
LOC111141989	LOC111160101	A0A2Y9IQ17	A0A2Y9LB05	Low-density lipoprotein receptor-related protein 2.	Prolow-density lipoprotein receptor-related protein 1.	0.907