(29 nodes) Generation of second messenger molecules network (Enhydra lutris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111150530	wiskott-Aldrich syndrome protein. (501 aa)
	LOC111160957	Serine/threonine-protein kinase PAK 3. (580 aa)
	LOC111161189	Protein spinster homolog 3 isoform X1. (578 aa)
	LOC111162218	Protein spinster homolog 1 isoform X1. (528 aa)
	LOC111162219	Linker for activation of T-cells family member 1 isoform X1. (260 aa)
	LOC111152200	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (254 aa)
	LOC111152151	SLA class II histocompatibility antigen, DQ haplotype C beta chain-like. (270 aa)
	LOC111150748	T-cell surface glycoprotein CD3 zeta chain isoform X1. (185 aa)
	LOC111152259	DLA class II histocompatibility antigen, DR-1 beta chain isoform X1. (291 aa)
	LOC111152178	LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like. (271 aa)
	LOC111152451	LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain; Belongs to the MHC class II family. (265 aa)
	LOC111153842	T-cell surface glycoprotein CD3 gamma chain. (180 aa)
	LOC111153962	T-cell surface glycoprotein CD3 epsilon chain isoform X1. (192 aa)
	LOC111143427	Immunoglobulin superfamily member 2 isoform X1. (1019 aa)
	LOC111155007	Cytoplasmic protein. (377 aa)
	LOC111152356	HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1. (279 aa)
	LOC111152358	LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family. (241 aa)
	LOC111152452	HLA class II histocompatibility antigen, DP beta 1 chain-like. (255 aa)
	LOC111153823	T-cell surface glycoprotein CD3 delta chain isoform X1. (169 aa)
	LOC111154988	Non-specific serine/threonine protein kinase. (524 aa)
	LOC111152978	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	LOC111154419	Non-specific serine/threonine protein kinase. (544 aa)
	LOC111155922	Tyrosine-protein kinase. (616 aa)
	LOC111157579	GRB2-related adapter protein 2 isoform X1. (316 aa)
	LOC111159821	T-cell surface glycoprotein CD4 isoform X1. (463 aa)
	LOC111140995	Tyrosine-protein kinase. (620 aa)
	LOC111140907	FYN-binding protein. (837 aa)
	LOC111140829	Lymphocyte cytosolic protein 2. (533 aa)
	LOC111141423	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111140829	LOC111140907	A0A2Y9IRX7	A0A2Y9ISD2	Lymphocyte cytosolic protein 2.	FYN-binding protein.	0.946
LOC111140829	LOC111140995	A0A2Y9IRX7	A0A2Y9ISR9	Lymphocyte cytosolic protein 2.	Tyrosine-protein kinase.	0.985
LOC111140829	LOC111141423	A0A2Y9IRX7	A0A2Y9IM88	Lymphocyte cytosolic protein 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.985
LOC111140829	LOC111150530	A0A2Y9IRX7	A0A2Y9K1Z9	Lymphocyte cytosolic protein 2.	wiskott-Aldrich syndrome protein.	0.604
LOC111140829	LOC111150748	A0A2Y9IRX7	A0A2Y9JTI3	Lymphocyte cytosolic protein 2.	T-cell surface glycoprotein CD3 zeta chain isoform X1.	0.694
LOC111140829	LOC111152200	A0A2Y9IRX7	A0A2Y9JZ42	Lymphocyte cytosolic protein 2.	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	0.481
LOC111140829	LOC111152358	A0A2Y9IRX7	A0A2Y9KAT3	Lymphocyte cytosolic protein 2.	LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family.	0.481
LOC111140829	LOC111152978	A0A2Y9IRX7	A0A2Y9KDH7	Lymphocyte cytosolic protein 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.990
LOC111140829	LOC111153823	A0A2Y9IRX7	A0A2Y9KB18	Lymphocyte cytosolic protein 2.	T-cell surface glycoprotein CD3 delta chain isoform X1.	0.670
LOC111140829	LOC111153842	A0A2Y9IRX7	A0A2Y9K642	Lymphocyte cytosolic protein 2.	T-cell surface glycoprotein CD3 gamma chain.	0.579
LOC111140829	LOC111153962	A0A2Y9IRX7	A0A2Y9K6L6	Lymphocyte cytosolic protein 2.	T-cell surface glycoprotein CD3 epsilon chain isoform X1.	0.644
LOC111140829	LOC111154419	A0A2Y9IRX7	A0A2Y9KDZ3	Lymphocyte cytosolic protein 2.	Non-specific serine/threonine protein kinase.	0.485
LOC111140829	LOC111154988	A0A2Y9IRX7	A0A2Y9KC05	Lymphocyte cytosolic protein 2.	Non-specific serine/threonine protein kinase.	0.548
LOC111140829	LOC111155007	A0A2Y9IRX7	A0A2Y9KAF6	Lymphocyte cytosolic protein 2.	Cytoplasmic protein.	0.997
LOC111140829	LOC111155922	A0A2Y9IRX7	A0A2Y9KG41	Lymphocyte cytosolic protein 2.	Tyrosine-protein kinase.	0.983
LOC111140829	LOC111157579	A0A2Y9IRX7	A0A2Y9KU87	Lymphocyte cytosolic protein 2.	GRB2-related adapter protein 2 isoform X1.	0.999
LOC111140829	LOC111160957	A0A2Y9IRX7	A0A2Y9L195	Lymphocyte cytosolic protein 2.	Serine/threonine-protein kinase PAK 3.	0.421
LOC111140829	LOC111162219	A0A2Y9IRX7	A0A2Y9L811	Lymphocyte cytosolic protein 2.	Linker for activation of T-cells family member 1 isoform X1.	0.973
LOC111140907	LOC111140829	A0A2Y9ISD2	A0A2Y9IRX7	FYN-binding protein.	Lymphocyte cytosolic protein 2.	0.946
LOC111140907	LOC111157579	A0A2Y9ISD2	A0A2Y9KU87	FYN-binding protein.	GRB2-related adapter protein 2 isoform X1.	0.788