(24 nodes) Citric acid cycle (TCA cycle) network (Enhydra lutris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	LOC111139143	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (392 aa)
	LOC111141000	NAD(P) transhydrogenase, mitochondrial isoform X1. (1085 aa)
	LOC111138865	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1. (169 aa)
	LOC111150761	Fumarate hydratase, mitochondrial. (508 aa)
	LOC111149687	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like. (389 aa)
	LOC111160144	Citrate synthase; Belongs to the citrate synthase family. (466 aa)
	LOC111157029	2-oxoglutarate dehydrogenase, mitochondrial isoform X1. (1023 aa)
	LOC111157631	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (781 aa)
	LOC111156081	Acylpyruvase FAHD1, mitochondrial. (221 aa)
	LOC111155288	Dihydrolipoyl dehydrogenase. (509 aa)
	LOC111153893	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
	LOC111154638	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (282 aa)
	LOC111152653	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (451 aa)
	LOC111153400	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (687 aa)
	LOC111152585	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (366 aa)
	LOC111148511	2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). (455 aa)
	LOC111148033	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (346 aa)
	LOC111145064	2-oxoglutarate dehydrogenase-like, mitochondrial. (1006 aa)
	LOC111146991	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (463 aa)
	LOC111145638	Malate dehydrogenase. (338 aa)
	LOC111144203	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (432 aa)
	LOC111142587	Malic enzyme. (589 aa)
	LOC111141366	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (437 aa)
	LOC111141119	NAD(P) transhydrogenase, mitochondrial-like. (118 aa)

Your Current Organism:

Enhydra lutris

NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111138865	LOC111139143	A0A2Y9IH42	A0A2Y9ILT8	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.467
LOC111138865	LOC111141366	A0A2Y9IH42	A0A2Y9IMY7	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.544
LOC111138865	LOC111144203	A0A2Y9IH42	A0A2Y9IZQ4	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.993
LOC111138865	LOC111145064	A0A2Y9IH42	A0A2Y9JC96	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	2-oxoglutarate dehydrogenase-like, mitochondrial.	0.796
LOC111138865	LOC111145638	A0A2Y9IH42	A0A2Y9J651	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Malate dehydrogenase.	0.472
LOC111138865	LOC111146991	A0A2Y9IH42	A0A2Y9JBV5	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.993
LOC111138865	LOC111148033	A0A2Y9IH42	A0A2Y9JGC5	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	0.998
LOC111138865	LOC111148511	A0A2Y9IH42	A0A2Y9JIG2	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase).	0.591
LOC111138865	LOC111149687	A0A2Y9IH42	A0A2Y9JSU2	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like.	0.467
LOC111138865	LOC111150761	A0A2Y9IH42	A0A2Y9JSN3	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Fumarate hydratase, mitochondrial.	0.993
LOC111138865	LOC111152585	A0A2Y9IH42	A0A2Y9K0X6	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.468
LOC111138865	LOC111152653	A0A2Y9IH42	A0A2Y9K5F4	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.530
LOC111138865	LOC111153400	A0A2Y9IH42	A0A2Y9K4J9	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.999
LOC111138865	LOC111153893	A0A2Y9IH42	A0A2Y9KBD5	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family.	0.999
LOC111138865	LOC111154638	A0A2Y9IH42	A0A2Y9K8Q7	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.999
LOC111138865	LOC111155288	A0A2Y9IH42	A0A2Y9KBL2	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Dihydrolipoyl dehydrogenase.	0.509
LOC111138865	LOC111156081	A0A2Y9IH42	A0A2Y9KF44	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Acylpyruvase FAHD1, mitochondrial.	0.808
LOC111138865	LOC111157029	A0A2Y9IH42	A0A2Y9KRN9	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	2-oxoglutarate dehydrogenase, mitochondrial isoform X1.	0.820
LOC111138865	LOC111157631	A0A2Y9IH42	A0A2Y9KP91	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.585
LOC111138865	LOC111160144	A0A2Y9IH42	A0A2Y9KYH8	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1.	Citrate synthase; Belongs to the citrate synthase family.	0.866