STRINGSTRING
LOC111139109 LOC111139109 LOC111139191 LOC111139191 LOC111140276 LOC111140276 LOC111141024 LOC111141024 LOC111141134 LOC111141134 LOC111141150 LOC111141150 LOC111141620 LOC111141620 LOC111141312 LOC111141312 LOC111141614 LOC111141614 LOC111141432 LOC111141432 LOC111143174 LOC111143174 LOC111142441 LOC111142441 LOC111142759 LOC111142759 LOC111143470 LOC111143470 LOC111143783 LOC111143783 LOC111143790 LOC111143790 LOC111142126 LOC111142126 LOC111143343 LOC111143343 LOC111142395 LOC111142395 LOC111144543 LOC111144543 LOC111144860 LOC111144860 LOC111144887 LOC111144887 LOC111144921 LOC111144921 LOC111144397 LOC111144397 LOC111143741 LOC111143741 LOC111144883 LOC111144883 LOC111145849 LOC111145849 LOC111146071 LOC111146071 LOC111147365 LOC111147365 LOC111147545 LOC111147545 LOC111147686 LOC111147686 LOC111146042 LOC111146042 LOC111148709 LOC111148709 LOC111149174 LOC111149174 LOC111148592 LOC111148592 LOC111149616 LOC111149616 LOC111148765 LOC111148765 LOC111148821 LOC111148821 LOC111150005 LOC111150005 LOC111149115 LOC111149115 LOC111150027 LOC111150027 LOC111150468 LOC111150468 LOC111150885 LOC111150885 LOC111148602 LOC111148602 LOC111150748 LOC111150748 LOC111151100 LOC111151100 LOC111148800 LOC111148800 LOC111151516 LOC111151516 LOC111151537 LOC111151537 LOC111151720 LOC111151720 LOC111150909 LOC111150909 LOC111152183 LOC111152183 LOC111152267 LOC111152267 LOC111149956 LOC111149956 LOC111151681 LOC111151681 LOC111150819 LOC111150819 LOC111152248 LOC111152248 LOC111151068 LOC111151068 LOC111153611 LOC111153611 LOC111153498 LOC111153498 LOC111154016 LOC111154016 LOC111153842 LOC111153842 LOC111153735 LOC111153735 LOC111153962 LOC111153962 LOC111151532 LOC111151532 LOC111151630 LOC111151630 LOC111154409 LOC111154409 LOC111153499 LOC111153499 LOC111153823 LOC111153823 LOC111154734 LOC111154734 LOC111155003 LOC111155003 LOC111155682 LOC111155682 LOC111155312 LOC111155312 LOC111154641 LOC111154641 LOC111154869 LOC111154869 LOC111156577 LOC111156577 LOC111156936 LOC111156936 LOC111157836 LOC111157836 LOC111157625 LOC111157625 LOC111155224 LOC111155224 LOC111158167 LOC111158167 LOC111158999 LOC111158999 LOC111159049 LOC111159049 LOC111157628 LOC111157628 LOC111157054 LOC111157054 LOC111158456 LOC111158456 LOC111157367 LOC111157367 LOC111158152 LOC111158152 LOC111161374 LOC111161374 LOC111161725 LOC111161725 LOC111158897 LOC111158897 LOC111161841 LOC111161841 LOC111161857 LOC111161857 LOC111162396 LOC111162396 LOC111159748 LOC111159748 LOC111161210 LOC111161210 LOC111162236 LOC111162236 LOC111161420 LOC111161420 LOC111161743 LOC111161743 LOC111160772 LOC111160772 LOC111162302 LOC111162302
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111139109Interleukin-1 receptor-associated kinase 1 isoform X3. (729 aa)
LOC111139191NF-kappa-B essential modulator. (412 aa)
LOC111140276NF-kappa-B inhibitor alpha isoform X1. (358 aa)
LOC111141024Serine/threonine-protein phosphatase. (309 aa)
LOC111141134CASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (482 aa)
LOC111141150Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
LOC1111416201-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
LOC111141312Neuroendocrine secretory protein 55. (249 aa)
LOC111141614LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (1019 aa)
LOC1111414321-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
LOC111143174Transcription factor AP-1; Belongs to the bZIP family. (334 aa)
LOC111142441Guanine nucleotide-binding protein G(Olf) subunit alpha isoform X1. (455 aa)
LOC111142759Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
LOC111143470Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (507 aa)
LOC111143783Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
LOC111143790Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
LOC111142126Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LOC111143343Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
LOC111142395Mothers against decapentaplegic homolog. (467 aa)
LOC111144543Serine/threonine-protein phosphatase. (309 aa)
LOC111144860Mitogen-activated protein kinase. (427 aa)
LOC111144887Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
LOC111144921Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
LOC111144397Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
LOC111143741Toll-like receptor 9 isoform X1. (1327 aa)
LOC111144883Tumor necrosis factor receptor superfamily member 6. (331 aa)
LOC111145849Plasminogen activator inhibitor 1; Belongs to the serpin family. (400 aa)
LOC111146071Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
LOC111147365Interleukin-6 isoform X2. (212 aa)
LOC111147545Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC111147686Interferon gamma receptor 1. (474 aa)
LOC111146042Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (833 aa)
LOC111148709B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
LOC111149174Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
LOC111148592Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
LOC111149616FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
LOC111148765Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC111148821Kininogen-1 isoform X1. (661 aa)
LOC1111500051-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1231 aa)
LOC111149115Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
LOC111150027TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
LOC111150468Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
LOC111150885Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC111148602Proto-oncogene c-Fos. (380 aa)
LOC111150748T-cell surface glycoprotein CD3 zeta chain isoform X1. (185 aa)
LOC111151100Interleukin-10. (178 aa)
LOC111148800Toll-like receptor 6; Belongs to the Toll-like receptor family. (793 aa)
LOC111151516C-C motif chemokine. (91 aa)
LOC111151537Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
LOC111151720Regakine-1-like. (107 aa)
LOC111150909Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (335 aa)
LOC111152183Mitogen-activated protein kinase. (360 aa)
LOC111152267Mitogen-activated protein kinase. (366 aa)
LOC111149956Transcription factor p65. (542 aa)
LOC111151681C-C motif chemokine. (93 aa)
LOC111150819Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (435 aa)
LOC111152248Tumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family. (234 aa)
LOC111151068Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC111153611Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
LOC111153498Guanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
LOC111154016Mitogen-activated protein kinase. (464 aa)
LOC111153842T-cell surface glycoprotein CD3 gamma chain. (180 aa)
LOC111153735Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (663 aa)
LOC111153962T-cell surface glycoprotein CD3 epsilon chain isoform X1. (192 aa)
LOC111151532C-C motif chemokine. (101 aa)
LOC111151630C-C motif chemokine. (93 aa)
LOC111154409Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
LOC111153499Guanine nucleotide-binding protein subunit alpha-14. (355 aa)
LOC111153823T-cell surface glycoprotein CD3 delta chain isoform X1. (169 aa)
LOC111154734Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
LOC111155003LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC111155682Interferon gamma receptor 2 isoform X2. (353 aa)
LOC111155312Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
LOC111154641Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LOC111154869Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
LOC111156577Interferon beta. (186 aa)
LOC111156936Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (550 aa)
LOC111157836Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
LOC111157625Mitogen-activated protein kinase. (364 aa)
LOC111155224Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC111158167Angiotensin-converting enzyme. (790 aa)
LOC111158999TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
LOC111159049Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LOC111157628Mitogen-activated protein kinase 12 isoform X1. (486 aa)
LOC111157054Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1138 aa)
LOC111158456Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
LOC111157367Guanine nucleotide-binding protein G(O) subunit alpha. (354 aa)
LOC111158152Angiotensin-converting enzyme. (1313 aa)
LOC111161374Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC111161725TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (763 aa)
LOC111158897Mitogen-activated protein kinase 9 isoform X1. (443 aa)
LOC111161841Complement C3. (1660 aa)
LOC111161857Guanine nucleotide-binding protein subunit alpha-11. (353 aa)
LOC111162396Calreticulin. (417 aa)
LOC111159748Tumor necrosis factor receptor superfamily member 1A. (458 aa)
LOC111161210Dual specificity mitogen-activated protein kinase kinase 4 isoform X2; Belongs to the protein kinase superfamily. (411 aa)
LOC111162236Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa)
LOC111161420Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
LOC111161743Guanine nucleotide-binding protein subunit alpha-15. (374 aa)
LOC111160772Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1. (590 aa)
LOC1111623021-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1220 aa)
Your Current Organism:
Enhydra lutris
NCBI taxonomy Id: 391180
Other names: E. lutris kenyoni, Enhydra lutris kenyoni
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