STRINGSTRING
secF secF EDM82828.1 EDM82828.1 EDM82280.1 EDM82280.1 EDM82407.1 EDM82407.1 EDM84001.1 EDM84001.1 EDM83982.1 EDM83982.1 ftsB ftsB EDM83039.1 EDM83039.1 EDM82994.1 EDM82994.1 clpB clpB EDM83180.1 EDM83180.1 EDM83505.1 EDM83505.1 secD secD yajC yajC EDM83822.1 EDM83822.1 EDM83757.1 EDM83757.1 EDM83754.1 EDM83754.1 secY secY EDM83328.1 EDM83328.1 ffh ffh EDM83320.1 EDM83320.1 EDM83311.1 EDM83311.1 EDM83310.1 EDM83310.1 EDM83309.1 EDM83309.1 secA secA EDM85179.1 EDM85179.1 EDM85178.1 EDM85178.1 EDM85176.1 EDM85176.1 tatC tatC tatB tatB tatA tatA EDM85114.1 EDM85114.1 EDM85113.1 EDM85113.1 EDM85112.1 EDM85112.1 EDM85108.1 EDM85108.1 EDM85107.1 EDM85107.1 ftsY ftsY secB secB EDM84938.1 EDM84938.1 EDM84937.1 EDM84937.1 EDM84936.1 EDM84936.1 EDM84935.1 EDM84935.1 EDM84934.1 EDM84934.1 EDM84933.1 EDM84933.1 EDM84932.1 EDM84932.1 EDM84929.1 EDM84929.1 EDM84928.1 EDM84928.1 EDM84927.1 EDM84927.1 EDM84896.1 EDM84896.1 EDM84892.1 EDM84892.1 EDM84891.1 EDM84891.1 EDM84817.1 EDM84817.1 yidC yidC EDM84590.1 EDM84590.1 EDM84585.1 EDM84585.1 EDM84584.1 EDM84584.1 fliP fliP EDM84582.1 EDM84582.1 EDM84569.1 EDM84569.1 EDM84566.1 EDM84566.1 EDM84497.1 EDM84497.1 EDM84496.1 EDM84496.1 EDM84493.1 EDM84493.1 EDM84489.1 EDM84489.1 EDM84488.1 EDM84488.1 EDM84487.1 EDM84487.1 secE secE EDM81971.1 EDM81971.1 EDM81962.1 EDM81962.1 EDM81987.1 EDM81987.1 EDM84381.1 EDM84381.1 EDM84227.1 EDM84227.1 EDM83116.1 EDM83116.1 EDM82080.1 EDM82080.1 EDM82076.1 EDM82076.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
secFProtein export protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (317 aa)
EDM82828.1Lytic transglycosylase, catalytic; COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains). (286 aa)
EDM82280.1Lytic transglycosylase, catalytic; COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains). (663 aa)
EDM82407.1Putative ATP-dependent Clp protease ATP- binding subunit; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. (774 aa)
EDM84001.1Type I secretion membrane fusion protein, HlyD; COG0845 Membrane-fusion protein. (452 aa)
EDM83982.1COG3012 Uncharacterized protein conserved in bacteria; Belongs to the UPF0225 family. (145 aa)
ftsBCell divison protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (109 aa)
EDM83039.1Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (110 aa)
EDM82994.1Surface antigen (D15); COG2831 Hemolysin activation/secretion protein. (546 aa)
clpBProbable atp-dependent protease (heat shock protein); Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (862 aa)
EDM83180.1Probable activation/secretion signal peptide protein; COG2831 Hemolysin activation/secretion protein. (546 aa)
EDM83505.1Hypothetical protein. (129 aa)
secDProtein export protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (620 aa)
yajCPutative secreted protein; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (113 aa)
EDM83822.1Cation/multidrug efflux system outer membrane porin; COG1538 Outer membrane protein. (470 aa)
EDM83757.1Pili assembly protein PilQ; COG0860 N-acetylmuramoyl-L-alanine amidase. (681 aa)
EDM83754.1COG3166 Tfp pilus assembly protein PilN. (192 aa)
secYProtein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (435 aa)
EDM83328.1COG3157 Hemolysin-coregulated protein (uncharacterized). (160 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] (465 aa)
EDM83320.1Hypothetical protein; COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains). (217 aa)
EDM83311.1Type II secretion system protein E:General secretory system II, protein E, N-terminal; COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB. (565 aa)
EDM83310.1Type II secretion system protein; COG1459 Type II secretory pathway, component PulF. (412 aa)
EDM83309.1Prepilin cysteine protease (C20) PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (279 aa)
secAPreprotein translocase ATPase subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (920 aa)
EDM85179.1Type II secretion system protein; COG1459 Type II secretory pathway, component PulF. (416 aa)
EDM85178.1COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB. (566 aa)
EDM85176.1Type II and III secretion system protein; COG1450 Type II secretory pathway, component PulD; Belongs to the bacterial secretin family. (531 aa)
tatCPutative Sec-independent protein translocase protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (245 aa)
tatBTwin-arginine translocation protein TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (142 aa)
tatATwin argininte translocase protein A; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (78 aa)
EDM85114.1COG1450 Type II secretory pathway, component PulD; Belongs to the bacterial secretin family. (646 aa)
EDM85113.1Type II secretion system protein E:General secretory system II, protein E, N-terminal; COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB. (331 aa)
EDM85112.1Hypothetical protein; COG1459 Type II secretory pathway, component PulF. (345 aa)
EDM85108.1Hypothetical protein. (249 aa)
EDM85107.1Hypothetical protein. (214 aa)
ftsYSignal recognition particle-docking protein FtsY(cell division protein); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (313 aa)
secBProtein export chaperone SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (159 aa)
EDM84938.1Hypothetical protein. (161 aa)
EDM84937.1General secretion pathway protein G; COG2165 Type II secretory pathway, pseudopilin PulG. (149 aa)
EDM84936.1Hypothetical protein; COG2165 Type II secretory pathway, pseudopilin PulG. (169 aa)
EDM84935.1General secretion pathway protein I; COG2165 Type II secretory pathway, pseudopilin PulG. (124 aa)
EDM84934.1COG4795 Type II secretory pathway, component PulJ. (232 aa)
EDM84933.1General secretion pathway protein K; COG3156 Type II secretory pathway, component PulK. (316 aa)
EDM84932.1Hypothetical protein. (417 aa)
EDM84929.1Type II and III secretion system protein; COG1450 Type II secretory pathway, component PulD. (807 aa)
EDM84928.1Type II secretion system protein E; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (487 aa)
EDM84927.1General secretion pathway protein F; COG1459 Type II secretory pathway, component PulF. (404 aa)
EDM84896.1Probable ClpA/B-type chaperone; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. (880 aa)
EDM84892.1COG3157 Hemolysin-coregulated protein (uncharacterized). (160 aa)
EDM84891.1COG3157 Hemolysin-coregulated protein (uncharacterized). (156 aa)
EDM84817.1Type II secretory pathway component PulD-like protein; COG0457 FOG: TPR repeat; Belongs to the bacterial secretin family. (633 aa)
yidC60 kDa inner membrane insertion protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (558 aa)
EDM84590.1COG4789 Type III secretory pathway, component EscV. (705 aa)
EDM84585.1Yop virulence translocation protein R; COG4790 Type III secretory pathway, component EscR. (217 aa)
EDM84584.1Hypothetical protein; COG4794 Type III secretory pathway, component EscS. (88 aa)
fliPFlagellar biosynthesis protein P; COG4791 Type III secretory pathway, component EscT. (266 aa)
EDM84582.1COG4792 Type III secretory pathway, component EscU. (353 aa)
EDM84569.1Putative type III secretion protein; COG1450 Type II secretory pathway, component PulD. (530 aa)
EDM84566.1COG4669 Type III secretory pathway, lipoprotein EscJ. (265 aa)
EDM84497.1COG3523 Uncharacterized protein conserved in bacteria. (1157 aa)
EDM84496.1COG3455 Uncharacterized protein conserved in bacteria. (454 aa)
EDM84493.1COG3501 Uncharacterized protein conserved in bacteria. (685 aa)
EDM84489.1Hypothetical protein; COG3456 Uncharacterized conserved protein, contains FHA domain. (337 aa)
EDM84488.1COG0631 Serine/threonine protein phosphatase. (261 aa)
EDM84487.1COG2831 Hemolysin activation/secretion protein. (566 aa)
secESecE subunit of protein translocation complex; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (156 aa)
EDM81971.1Type IV pilus biogenesis protein. (358 aa)
EDM81962.1Conserved protein with nucleoside triphosphate hydrolase domain; COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB. (289 aa)
EDM81987.1Type IV B pilus protein; COG1450 Type II secretory pathway, component PulD. (312 aa)
EDM84381.1Hypothetical protein. (208 aa)
EDM84227.1COG0845 Membrane-fusion protein. (452 aa)
EDM83116.1COG0631 Serine/threonine protein phosphatase. (572 aa)
EDM82080.1Conjugal transfer protein TraG; COG3505 Type IV secretory pathway, VirD4 components. (753 aa)
EDM82076.1Conjugal transfer protein; COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains). (202 aa)
Your Current Organism:
Limnobacter sp. MED105
NCBI taxonomy Id: 391597
Other names: L. sp. MED105
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