STRINGSTRING
pckA pckA AGI66321.1 AGI66321.1 gabD2 gabD2 pyc pyc glcB glcB ppdK ppdK lipB lipB AGI67594.1 AGI67594.1 acnA acnA gltA gltA lipA lipA pdhA pdhA pdhB pdhB pdhC pdhC lpd1 lpd1 fumC fumC AGI68977.1 AGI68977.1 AGI68978.1 AGI68978.1 AGI68979.1 AGI68979.1 AGI68981.1 AGI68981.1 icd icd AGI69085.1 AGI69085.1 dme dme sdhB sdhB sdhA sdhA sdhD sdhD sdhC sdhC AGI69550.1 AGI69550.1 mdh mdh sucC sucC sucD sucD sucA sucA sucB sucB lpd2 lpd2 lpd3 lpd3 AGI69741.1 AGI69741.1 maeB maeB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (532 aa)
AGI66321.1Fumarylacetoacetate hydrolase family protein. (230 aa)
gabD2Succinate-semialdehyde dehydrogenase GabD; Belongs to the aldehyde dehydrogenase family. (492 aa)
pycPyruvate carboxylase Pyc; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1147 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (719 aa)
ppdKPyruvate; Phosphate dikinase. (690 aa)
lipBOctanoyltransferase LipB; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (220 aa)
AGI67594.1Transketolase family protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (792 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (895 aa)
gltACitrate synthase GltA; Belongs to the citrate synthase family. (430 aa)
lipALipoyl synthase LipA; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (318 aa)
pdhAPyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (315 aa)
pdhBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (459 aa)
pdhCDihydrolipoyllysine-residue acetyltransferase PdhC; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (428 aa)
lpd1Dihydrolipoyl dehydrogenase Lpd. (472 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
AGI68977.1Putative acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha. (327 aa)
AGI68978.1Putative acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit beta. (331 aa)
AGI68979.1Putative dihydrolipoyllysine-residue acetyltransferase. (437 aa)
AGI68981.1Putative dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex. (312 aa)
icdIsocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (403 aa)
AGI69085.1Fumarate reductase/succinate dehydrogenaseflavoprotein domain protein. (456 aa)
dmeNAD-dependent malic enzyme Dme. (770 aa)
sdhBSuccinate dehydrogenase iron-sulfur subunit SdhB; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
sdhASuccinate dehydrogenase flavoprotein subunit SdhA; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (601 aa)
sdhDSuccinate dehydrogenase hydrophobic membrane anchor subunit SdhD. (123 aa)
sdhCSuccinate dehydrogenase cytochrome b556 subunit SdhC. (127 aa)
AGI69550.1Putative citrate lyase subunit beta; Belongs to the HpcH/HpaI aldolase family. (278 aa)
mdhMalate dehydrogenase Mdh; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
sucCsuccinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)
sucDsuccinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
sucA2-oxoglutarate dehydrogenase E1 componentSucA; Alternative name(s): alpha-ketoglutarate dehydrogenase. (986 aa)
sucBDihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (520 aa)
lpd2Dihydrolipoyl dehydrogenase Lpd; E3 component of 2-oxoglutarate dehydrogenase complex. (462 aa)
lpd3Dihydrolipoyl dehydrogenase Lpd. (475 aa)
AGI69741.1Hypothetical protein; Related to SNARE associated Golgi protein. (250 aa)
maeBNADP-dependent malic enzyme MaeB. (751 aa)
Your Current Organism:
Octadecabacter antarcticus
NCBI taxonomy Id: 391626
Other names: O. antarcticus 307, Octadecabacter antarcticus 307, Octadecabacter antarcticus CIP 106731, Octadecabacter antarcticus str. 307, Octadecabacter antarcticus strain 307, unidentified alpha proteobacterium (clone 307), unidentified alpha proteobacterium clone 307
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.