STRINGSTRING
dnaN dnaN recF recF gyrB gyrB AGI65806.1 AGI65806.1 uvrC uvrC AGI66003.1 AGI66003.1 parC parC dnaX dnaX polA polA priA priA AGI66819.1 AGI66819.1 pcrA pcrA recN recN xseA xseA dnaE2 dnaE2 imuB imuB AGI67345.1 AGI67345.1 parE parE AGI67478.1 AGI67478.1 AGI67538.1 AGI67538.1 AGI67834.1 AGI67834.1 AGI67975.1 AGI67975.1 ligA ligA recG recG gyrA gyrA mfd mfd AGI68292.1 AGI68292.1 uvrA uvrA AGI68702.1 AGI68702.1 AGI69034.1 AGI69034.1 recA recA AGI69219.1 AGI69219.1 dnaE1 dnaE1 AGI69303.1 AGI69303.1 topA topA AGI69333.1 AGI69333.1 uvrB uvrB xseB xseB mutL mutL AGI70008.1 AGI70008.1 AGI70029.1 AGI70029.1 AGI70081.1 AGI70081.1 recQ recQ mutS mutS dnaQ dnaQ
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dnaNDNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (369 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (805 aa)
AGI65806.1Hypothetical protein. (289 aa)
uvrCUvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (621 aa)
AGI66003.1Type IA DNA topoisomerase; Topoisomerase 3-like. (717 aa)
parCDNA topoisomerase 4 subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (803 aa)
dnaXDNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (561 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (928 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (730 aa)
AGI66819.1Putative single-stranded-DNA-specific exonuclease. (588 aa)
pcrAATP-dependent DNA helicase PcrA. (833 aa)
recNDNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (549 aa)
xseAExodeoxyribonuclease 7 large subunit XseA; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (513 aa)
dnaE2DNA polymerase III subunit alpha; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1105 aa)
imuBPutative protein ImuB. (589 aa)
AGI67345.1Hypothetical protein. (231 aa)
parEDNA topoisomerase 4 subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (652 aa)
AGI67478.1Type IA DNA topoisomerase; Topoisomerase 3-like. (703 aa)
AGI67538.1Putative exonuclease. (202 aa)
AGI67834.1Competence protein E-like protein. (697 aa)
AGI67975.1Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (180 aa)
ligADNA ligase LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (706 aa)
recGATP-dependent DNA helicase RecG. (690 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (921 aa)
mfdTranscription-repair-coupling factor Mfd; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1164 aa)
AGI68292.1Putative DNA polymerase III chi subunit. (152 aa)
uvrAuvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (952 aa)
AGI68702.1UPF0243 zinc-binding protein-like. (60 aa)
AGI69034.1Hypothetical protein; Similar to DNA polymerase III delta subunit. (384 aa)
recAProtein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (359 aa)
AGI69219.1Hypothetical protein. (117 aa)
dnaE1DNA polymerase III subunit alpha. (1194 aa)
AGI69303.1SMF family protein. (376 aa)
topADNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (888 aa)
AGI69333.1Magnesium chelatase. (503 aa)
uvrBUvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (735 aa)
xseBExodeoxyribonuclease 7 small subunit XseB; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (78 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (613 aa)
AGI70008.1Hypothetical protein DUF2466; Belongs to the UPF0758 family. (266 aa)
AGI70029.1Putative ComF/GntX family protein. (239 aa)
AGI70081.1Hypothetical protein. (342 aa)
recQATP-dependent DNA helicase RecQ. (677 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (864 aa)
dnaQDNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (242 aa)
Your Current Organism:
Octadecabacter antarcticus
NCBI taxonomy Id: 391626
Other names: O. antarcticus 307, Octadecabacter antarcticus 307, Octadecabacter antarcticus CIP 106731, Octadecabacter antarcticus str. 307, Octadecabacter antarcticus strain 307, unidentified alpha proteobacterium (clone 307), unidentified alpha proteobacterium clone 307
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