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rpsF rpsF gyrB gyrB AGI65871.1 AGI65871.1 AGI65875.1 AGI65875.1 AGI65896.1 AGI65896.1 AGI65994.1 AGI65994.1 rpmI rpmI rplT rplT AGI66003.1 AGI66003.1 smc smc recO recO AGI66082.1 AGI66082.1 parC parC rplK rplK rplA rplA rpsU2 rpsU2 AGI66219.1 AGI66219.1 recR recR AGI66309.1 AGI66309.1 clpS clpS rpmE rpmE rplS rplS rimM rimM rpsP rpsP priA priA AGI66736.1 AGI66736.1 AGI66775.1 AGI66775.1 AGI66824.1 AGI66824.1 betI betI recN recN AGI67001.1 AGI67001.1 AGI67058.1 AGI67058.1 rpmG rpmG dnaG dnaG AGI67207.1 AGI67207.1 AGI67248.1 AGI67248.1 parE parE AGI67394.1 AGI67394.1 AGI67425.1 AGI67425.1 AGI67426.1 AGI67426.1 AGI67465.1 AGI67465.1 AGI67473.1 AGI67473.1 AGI67478.1 AGI67478.1 AGI67486.1 AGI67486.1 AGI67515.1 AGI67515.1 AGI67520.1 AGI67520.1 AGI67584.1 AGI67584.1 AGI67601.1 AGI67601.1 nuoE nuoE AGI67735.1 AGI67735.1 dnaB dnaB AGI67937.1 AGI67937.1 gyrA gyrA rpsB rpsB rpsU rpsU AGI68135.1 AGI68135.1 AGI68144.1 AGI68144.1 rpsI rpsI rplM rplM rpmA rpmA rplU rplU AGI68270.1 AGI68270.1 AGI68292.1 AGI68292.1 rplI rplI AGI68430.1 AGI68430.1 AGI68459.1 AGI68459.1 AGI68484.1 AGI68484.1 AGI68536.1 AGI68536.1 gvpA gvpA gvpO gvpO gvpJ gvpJ gvpK gvpK rpsU1 rpsU1 AGI68605.1 AGI68605.1 AGI68668.1 AGI68668.1 AGI68673.1 AGI68673.1 AGI68755.1 AGI68755.1 AGI68825.1 AGI68825.1 AGI68926.1 AGI68926.1 AGI68927.1 AGI68927.1 AGI69010.1 AGI69010.1 AGI69024.1 AGI69024.1 AGI69116.1 AGI69116.1 AGI69137.1 AGI69137.1 rpmB rpmB AGI69188.1 AGI69188.1 topA topA rplY rplY ihfB ihfB rpsA rpsA AGI69416.1 AGI69416.1 AGI69590.1 AGI69590.1 AGI69684.1 AGI69684.1 AGI69717.1 AGI69717.1 rarA rarA rplQ rplQ rpsK rpsK rpsM rpsM rplO rplO rpmD rpmD rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsN rpsN rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ rpsG rpsG rpsL rpsL rplL rplL rplJ rplJ rpsU-2 rpsU-2 rpsO rpsO AGI69983.1 AGI69983.1 hpf hpf recQ recQ parB parB AGI70209.1 AGI70209.1 rpsT rpsT
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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rpsF30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (117 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (805 aa)
AGI65871.1Putative IS21-family mobile element-associated ATP-binding protein. (250 aa)
AGI65875.1Hypothetical protein; Putative glutathione-dependent formaldehyde-activating(GFA) family-like. (132 aa)
AGI65896.1Class II aldolase. (251 aa)
AGI65994.1Hypothetical protein. (219 aa)
rpmI50S ribosomal protein L351; Belongs to the bacterial ribosomal protein bL35 family. (66 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa)
AGI66003.1Type IA DNA topoisomerase; Topoisomerase 3-like. (717 aa)
smcPutative chromosome partition protein smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1151 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (242 aa)
AGI66082.1cob[I]yrinic acid a,c-diamide adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa)
parCDNA topoisomerase 4 subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (803 aa)
rplK50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (232 aa)
rpsU2Ribsomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (68 aa)
AGI66219.1Putative TetR family transcriptional regulator. (205 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (183 aa)
AGI66309.1Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (114 aa)
clpSATP-dependent Clp protease adapter protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (195 aa)
rpmE50S ribosomal protein L31; Binds the 23S rRNA; Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily. (73 aa)
rplS50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (128 aa)
rimMRibosome maturation factor RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (203 aa)
rpsP30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (162 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (730 aa)
AGI66736.1HTH-type transcriptional regulator. (206 aa)
AGI66775.1Hypothetical protein; Similar to glutathione-dependent formaldehyde-activating enzyme. (162 aa)
AGI66824.1Transcriptional regulator. (213 aa)
betITranscriptional regulator; Repressor involved in choline regulation of the bet genes. (191 aa)
recNDNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (549 aa)
AGI67001.1Putative IS21-family mobile element; Associated ATP-binding protein. (250 aa)
AGI67058.1Putative tetR-like protein. (204 aa)
rpmG50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (55 aa)
dnaGPutative DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (654 aa)
AGI67207.1TetR family transcriptional regulator. (201 aa)
AGI67248.1DUF74-family protein; Associated with suf operon; Belongs to the UPF0145 family. (172 aa)
parEDNA topoisomerase 4 subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (652 aa)
AGI67394.1TetR family transcriptional regulator. (196 aa)
AGI67425.1Hypothetical protein. (313 aa)
AGI67426.1Hypothetical protein. (146 aa)
AGI67465.1Hypothetical protein. (363 aa)
AGI67473.1Putative IS21-family mobile element-associated ATP-binding protein; Associated ATP-binding protein. (250 aa)
AGI67478.1Type IA DNA topoisomerase; Topoisomerase 3-like. (703 aa)
AGI67486.1Putative TetR family transcriptional regulator. (218 aa)
AGI67515.1Hypothetical protein. (586 aa)
AGI67520.1Hypothetical protein. (229 aa)
AGI67584.1Hypothetical protein. (586 aa)
AGI67601.1Hypothetical protein. (586 aa)
nuoENADH-quinone oxidoreductase subunit E. (277 aa)
AGI67735.1Hypothetical protein; Associated with NADH-quinone oxidoreductase. (229 aa)
dnaBReplicative DNA helicase DnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (495 aa)
AGI67937.1Hypothetical protein. (80 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (921 aa)
rpsB30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (266 aa)
rpsUPutative ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (66 aa)
AGI68135.1tetR family transcriptional regulator. (229 aa)
AGI68144.1TetR family transcriptional regulator. (183 aa)
rpsI30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (166 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (154 aa)
rpmA5S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (89 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (229 aa)
AGI68270.1Putative GFA family protein; Alternative name(s): putative glutathione-dependent formaldehyde-activating family protein. (168 aa)
AGI68292.1Putative DNA polymerase III chi subunit. (152 aa)
rplI50S ribosomal protein L9; Binds to the 23S rRNA. (210 aa)
AGI68430.1Hypothetical protein DUF924. (201 aa)
AGI68459.1TetR family transcriptional regulator. (187 aa)
AGI68484.1Putative IS21-family mobile element-associated ATP-binding protein. (250 aa)
AGI68536.1Putative ATP-binding protein. (270 aa)
gvpAGas vesicle structural protein GvpA; Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. (67 aa)
gvpOGas vesicle protein GvpO. (71 aa)
gvpJGas vesicle structural protein GvpJ; Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. (112 aa)
gvpKGas vesicle protein GvpK. (132 aa)
rpsU130S ribosomal protein S21 A; Belongs to the bacterial ribosomal protein bS21 family. (66 aa)
AGI68605.1Putative IS21-family mobile element-associated ATP-binding protein. (250 aa)
AGI68668.1TetR family transcriptional regulator. (192 aa)
AGI68673.1Hypothetical protein. (148 aa)
AGI68755.1IstB-like ATP-binding domain-containing protein. (69 aa)
AGI68825.1Hypothetical protein. (81 aa)
AGI68926.1Putative gluthatione-dependent formaldehyde-activating [GFA] family protein. (125 aa)
AGI68927.1Putative gluthatione-dependent formaldehyde-activating [GFA] family protein. (121 aa)
AGI69010.1Restriction endonuclease family protein-like. (268 aa)
AGI69024.1Putative IS21-family mobile element-associated ATP-binding protein. (250 aa)
AGI69116.1Hypothetical protein. (126 aa)
AGI69137.1Hypothetical protein; Belongs to the SOS response-associated peptidase family. (218 aa)
rpmB50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (96 aa)
AGI69188.1Putative glutathione-dependent formaldehyde-activating [GFA] protein. (125 aa)
topADNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (888 aa)
rplY50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (215 aa)
ihfBIntegration host factor subunit beta; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (93 aa)
rpsA30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (555 aa)
AGI69416.1TetR family transcriptional regulator. (198 aa)
AGI69590.1Putative HTH-type transcriptional regulator. (204 aa)
AGI69684.1TetR family transcriptional regulator. (219 aa)
AGI69717.1Putative TetR family transcriptional regulator. (190 aa)
rarAReplication-associated recombination protein A. (435 aa)
rplQ50S ribosomal protein L17. (138 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (133 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (156 aa)
rpmD50S ribosomal protein L30. (62 aa)
rpsE30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (192 aa)
rplR50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (119 aa)
rplF50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (176 aa)
rpsH30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rpsN30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (187 aa)
rplX50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (101 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (75 aa)
rpmC50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (77 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (137 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (238 aa)
rplV50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (126 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (280 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (103 aa)
rplD50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (205 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (278 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsL30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (123 aa)
rplL50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (123 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (171 aa)
rpsU-230S ribosomal protein S21 A; Belongs to the bacterial ribosomal protein bS21 family. (66 aa)
rpsO30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
AGI69983.1Putative glutathione-dependent formaldehyde activating enzyme. (127 aa)
hpfPutative sigma 54 modulation protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (191 aa)
recQATP-dependent DNA helicase RecQ. (677 aa)
parBChromosome-partitioning protein ParB; Belongs to the ParB family. (296 aa)
AGI70209.1Putative IS21-family mobile element-associated ATP-binding protein. (250 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (87 aa)
Your Current Organism:
Octadecabacter antarcticus
NCBI taxonomy Id: 391626
Other names: O. antarcticus 307, Octadecabacter antarcticus 307, Octadecabacter antarcticus CIP 106731, Octadecabacter antarcticus str. 307, Octadecabacter antarcticus strain 307, unidentified alpha proteobacterium (clone 307), unidentified alpha proteobacterium clone 307
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