STRINGSTRING
Veis_5007 Veis_5007 dnaA dnaA Veis_0002 Veis_0002 gyrB gyrB priA priA dnaG dnaG Veis_0280 Veis_0280 Veis_0296 Veis_0296 dnaX dnaX rep rep Veis_0670 Veis_0670 Veis_0964 Veis_0964 dnaJ dnaJ priB priB Veis_0985 Veis_0985 Veis_1376 Veis_1376 Veis_1412 Veis_1412 Veis_1495 Veis_1495 Veis_1496 Veis_1496 dinB dinB Veis_1696 Veis_1696 Veis_1761 Veis_1761 polA polA Veis_2363 Veis_2363 dnaQ dnaQ Veis_2629 Veis_2629 gyrA gyrA Veis_3468 Veis_3468 Veis_3469 Veis_3469 Veis_3677 Veis_3677 Veis_3725 Veis_3725 Veis_3727 Veis_3727 Veis_3728 Veis_3728 Veis_3845 Veis_3845 Veis_4180 Veis_4180 Veis_4181 Veis_4181 Veis_4392 Veis_4392 Veis_4393 Veis_4393 ligA ligA smc smc Veis_4484 Veis_4484 lexA lexA Veis_4921 Veis_4921 Veis_4944 Veis_4944
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
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gene neighborhood
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gene co-occurrence
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textmining
co-expression
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Veis_5007Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (813 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (483 aa)
Veis_0002DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (868 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (712 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (653 aa)
Veis_0280KEGG: cch:Cag_1772 hypothetical protein. (281 aa)
Veis_0296Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (173 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (614 aa)
repUvrD/REP helicase; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (697 aa)
Veis_0670KEGG: sgl:SG1157 hypothetical protein. (158 aa)
Veis_0964TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta; KEGG: pol:Bpro_4600 DNA polymerase III, delta subunit. (351 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (381 aa)
priBSingle-strand binding protein/Primosomal replication protein n; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (96 aa)
Veis_0985Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (472 aa)
Veis_1376KEGG: xfa:XF1418 hypothetical protein. (128 aa)
Veis_1412KEGG: noc:Noc_A0020 hypothetical protein. (154 aa)
Veis_1495Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (399 aa)
Veis_1496Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (968 aa)
dinBDNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (432 aa)
Veis_1696PFAM: UvrD/REP helicase; KEGG: pol:Bpro_1723 UvrD/REP helicase. (793 aa)
Veis_1761Recombination protein MgsA; PFAM: AAA ATPase, central domain protein; SMART: AAA ATPase; KEGG: rfr:Rfer_3176 AAA ATPase. (452 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (936 aa)
Veis_2363KEGG: rfr:Rfer_0459 ATP-dependent DNA helicase RecQ; TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like. (622 aa)
dnaQDNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (237 aa)
Veis_2629KEGG: mca:MCA3009 PHP N-terminal domain protein. (929 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (914 aa)
Veis_3468KEGG: rru:Rru_B0024 RepA-related protein. (81 aa)
Veis_3469KEGG: rru:Rru_B0024 RepA-related protein. (139 aa)
Veis_3677PFAM: UvrD/REP helicase; KEGG: rme:Rmet_6314 UvrD/REP helicase. (621 aa)
Veis_3725KEGG: ilo:IL0002 DNA polymerase sliding clamp subunit. (366 aa)
Veis_3727PFAM: Phage P4 alpha, zinc-binding domain protein; KEGG: dar:Daro_2694 hypothetical protein. (361 aa)
Veis_3728Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (167 aa)
Veis_3845KEGG: eba:ebA5688 hypothetical protein. (108 aa)
Veis_4180KEGG: eca:ECA3852 DNA polymerase II. (270 aa)
Veis_4181DNA polymerase II; KEGG: pau:PA14_40120 DNA polymerase II. (211 aa)
Veis_4392KEGG: sgl:SG0934 hypothetical protein. (95 aa)
Veis_4393KEGG: sgl:SG0934 hypothetical protein. (95 aa)
ligADNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (693 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1175 aa)
Veis_4484KEGG: rfr:Rfer_2040 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP C-terminal domain protein; nucleic acid binding, OB-fold, tRNA/helicase-type; SMART: phosphoesterase PHP domain protein. (1186 aa)
lexASOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (224 aa)
Veis_4921PFAM: DNA polymerase III chi subunit, HolC; KEGG: pol:Bpro_2409 DNA polymerase III chi subunit, HolC. (144 aa)
Veis_4944Hypothetical protein; KEGG: pol:Bpro_1723 UvrD/REP helicase. (315 aa)
Your Current Organism:
Verminephrobacter eiseniae
NCBI taxonomy Id: 391735
Other names: V. eiseniae EF01-2, Verminephrobacter eiseniae EF01-2, Verminephrobacter eiseniae str. EF01-2, Verminephrobacter eiseniae strain EF01-2
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