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| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (175 aa) |
| | Veis_0014 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (911 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (373 aa) |
| | gpmA | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (245 aa) |
| | Veis_0037 | Dihydroxyacid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: pol:Bpro_3810 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (629 aa) |
| | Veis_0110 | PFAM: glutamine synthetase, catalytic region; KEGG: pol:Bpro_4698 glutamine synthetase, catalytic region. (458 aa) |
| | metXS | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (375 aa) |
| | Veis_0191 | KEGG: pol:Bpro_4826 glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa) |
| | Veis_0192 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (693 aa) |
| | Veis_0196 | PFAM: pyruvate kinase; KEGG: pol:Bpro_4634 pyruvate kinase; Belongs to the pyruvate kinase family. (496 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (459 aa) |
| | Veis_0268 | TIGRFAM: acetylornithine deacetylase (ArgE); PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: bte:BTH_I2086 acetylornithine deacetylase. (398 aa) |
| | Veis_0274 | PFAM: aminotransferase, class I and II; KEGG: pol:Bpro_1997 aminotransferase, class I and II. (409 aa) |
| | dapD | KEGG: rfr:Rfer_2046 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; TIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; PFAM: transferase hexapeptide repeat containing protein; Belongs to the transferase hexapeptide repeat family. (277 aa) |
| | dapE | Succinyldiaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (401 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (565 aa) |
| | Veis_0339 | PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: bur:Bcep18194_C6721 acetolactate synthase, large subunit. (576 aa) |
| | Veis_0587 | PFAM: ribulose-phosphate 3-epimerase; KEGG: rfr:Rfer_0532 ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (226 aa) |
| | Veis_0624 | Isocitrate dehydrogenase, NADP-dependent; KEGG: cvi:CV3664 probable isocitrate dehydrogenase (NADP); TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family. (745 aa) |
| | hisE | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rfr:Rfer_2953 phosphoribosyl-ATP pyrophosphohydrolase. (134 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (151 aa) |
| | Veis_0720 | PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: bch:Bcen2424_6609 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase. (424 aa) |
| | Veis_0722 | TIGRFAM: dihydrodipicolinate synthase; PFAM: dihydrodipicolinate synthetase; KEGG: bja:blr3302 dihydrodipicolinate synthase. (298 aa) |
| | Veis_0744 | TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: rme:Rmet_1610 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase. (453 aa) |
| | Veis_0789 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rfr:Rfer_0882 thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. (564 aa) |
| | Veis_0790 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: reh:H16_B0313 acetolactate synthase large subunit (TPP dependent). (564 aa) |
| | Veis_0825 | PFAM: glutamine synthetase, catalytic region; KEGG: rfr:Rfer_0350 glutamate--ammonia ligase. (456 aa) |
| | argA | N-acetylglutamate synthase; TIGRFAM: amino-acid N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; aspartate/glutamate/uridylate kinase; KEGG: rfr:Rfer_2105 amino-acid N-acetyltransferase (ArgA); Belongs to the acetyltransferase family. ArgA subfamily. (448 aa) |
| | Veis_0900 | PFAM: Transketolase domain protein; KEGG: psp:PSPPH_1256 transketolase, N-terminal subunit, putative. (296 aa) |
| | Veis_0901 | Transketolase subunit B; PFAM: Transketolase, central region; Transketolase domain protein; KEGG: rha:RHA1_ro03844 transketolase, C-terminal subunit. (336 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (437 aa) |
| | Veis_0965 | Arginase; TIGRFAM: arginase; PFAM: Arginase/agmatinase/formiminoglutamase; KEGG: xcv:XCV4102 arginase; Belongs to the arginase family. (341 aa) |
| | Veis_1026 | KEGG: pol:Bpro_3726 cysteine synthase B; TIGRFAM: cysteine synthases; cysteine synthase B; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (300 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (357 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (216 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (502 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (309 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (282 aa) |
| | Veis_1195 | Methionine synthase (B12-dependent); PFAM: homocysteine S-methyltransferase; KEGG: rfr:Rfer_0460 5-methyltetrahydrofolate--homocysteine S-methyltransferase. (370 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: pol:Bpro_4451 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (267 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (346 aa) |
| | Veis_1211 | Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: pol:Bpro_4455 glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase. (190 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (517 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (296 aa) |
| | Veis_1286 | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (470 aa) |
| | Veis_1307 | D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: pfl:PFL_5911 D-3-phosphoglycerate dehydrogenase. (409 aa) |
| | Veis_1342 | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (939 aa) |
| | Veis_1349 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: bja:blr2741 3-isopropylmalate dehydrogenase. (356 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: rfr:Rfer_1710 argininosuccinate lyase. (488 aa) |
| | Veis_1400 | KEGG: mag:amb2804 citrate synthase; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (444 aa) |
| | Veis_1461 | PFAM: Phosphoglycerate mutase; KEGG: rfr:Rfer_0816 phosphoglycerate mutase. (212 aa) |
| | Veis_1686 | L-threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: rfr:Rfer_3604 threonine aldolase. (356 aa) |
| | Veis_1745 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pol:Bpro_2317 acetolactate synthase, large subunit, biosynthetic type. (593 aa) |
| | Veis_1746 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: pol:Bpro_2318 acetolactate synthase, small subunit. (163 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (347 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (316 aa) |
| | thrB | KEGG: rfr:Rfer_1323 homoserine kinase; TIGRFAM: homoserine kinase; PFAM: aminoglycoside phosphotransferase; Belongs to the pseudomonas-type ThrB family. (316 aa) |
| | argD | TIGRFAM: acetylornithine and succinylornithine aminotransferases; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class-III; KEGG: pol:Bpro_3572 acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (400 aa) |
| | Veis_1910 | KEGG: bbr:BB4085 putative 3-isopropylmalate dehydratase large subunit; TIGRFAM: homoaconitate hydratase family protein; PFAM: aconitate hydratase domain protein. (428 aa) |
| | Veis_1911 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: bbr:BB4086 putative 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. (172 aa) |
| | Veis_1933 | PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rme:Rmet_3896 thiamine pyrophosphate enzyme-like TPP-binding. (513 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (255 aa) |
| | argH-2 | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: bam:Bamb_6457 argininosuccinate lyase. (480 aa) |
| | Veis_2009 | KEGG: bja:bll6374 citrate synthase. (261 aa) |
| | Veis_2017 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: sme:SMc01622 putative phosphoglycerate dehydrogenase. (352 aa) |
| | Veis_2042 | TIGRFAM: sugar-phosphate isomerases, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase; KEGG: pol:Bpro_1460 sugar-phosphate isomerases, RpiB/LacA/LacB family. (159 aa) |
| | Veis_2136 | KEGG: pol:Bpro_4215 phenylalanine-4-hydroxylase, monomeric form; TIGRFAM: phenylalanine-4-hydroxylase; PFAM: aromatic amino acid hydroxylase. (275 aa) |
| | Veis_2151 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: bch:Bcen2424_6169 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (319 aa) |
| | Veis_2189 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (371 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (288 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (159 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (282 aa) |
| | Veis_2368 | PFAM: dihydrodipicolinate synthetase; KEGG: reh:H16_B1831 dihydrodipicolinate synthase (DapA); Belongs to the DapA family. (301 aa) |
| | Veis_2370 | PFAM: aminotransferase, class I and II; KEGG: pol:Bpro_2175 aspartate transaminase. (401 aa) |
| | Veis_2395 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: rfr:Rfer_2933 glutamate synthase (ferredoxin). (1586 aa) |
| | Veis_2396 | TIGRFAM: glutamate synthases, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: rfr:Rfer_2934 glutamate synthases, NADH/NADPH, small subunit. (492 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (313 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | Veis_2662 | PFAM: aminotransferase, class I and II; KEGG: rfr:Rfer_1911 aminotransferase, class I and II. (409 aa) |
| | Veis_2663 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: rfr:Rfer_1912 homoserine dehydrogenase. (444 aa) |
| | Veis_2664 | KEGG: rfr:Rfer_1913 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (516 aa) |
| | argC-2 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (326 aa) |
| | Veis_2739 | PFAM: dihydrodipicolinate synthetase; KEGG: lxx:Lxx10270 dihydrodipicolinate synthase; Belongs to the DapA family. (312 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (270 aa) |
| | eno-2 | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (443 aa) |
| | Veis_2902 | PFAM: aminotransferase, class I and II; KEGG: bbr:BB3570 putative aspartate aminotransferase. (406 aa) |
| | Veis_2905 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: atc:AGR_pAT_470 hypothetical protein. (323 aa) |
| | Veis_3034 | PFAM: glutamine synthetase, catalytic region; KEGG: reh:H16_B2191 glutamine synthetase. (463 aa) |
| | serC | Aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (381 aa) |
| | Veis_3121 | TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; amino acid-binding ACT domain protein; KEGG: pol:Bpro_1792 chorismate mutase. (365 aa) |
| | Veis_3122 | PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase, NAD-binding; KEGG: rfr:Rfer_1568 prephenate dehydrogenase. (300 aa) |
| | cmk | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. (705 aa) |
| | Veis_3154 | KEGG: pol:Bpro_1807 glutamine synthetase, type I; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp. (471 aa) |
| | hisZ | tRNA synthetase, class II (G, H, P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (382 aa) |
| | ilvD | KEGG: pol:Bpro_2052 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (568 aa) |
| | Veis_3225 | KEGG: pol:Bpro_4369 L-serine dehydratase 1; TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (475 aa) |
| | Veis_3266 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: rfr:Rfer_1520 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (362 aa) |
| | Veis_3409 | Cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: rfr:Rfer_2294 Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. (426 aa) |
| | Veis_3461 | PFAM: argininosuccinate synthase; KEGG: rso:RSc2553 probable argininosuccinate synthase protein; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (453 aa) |
| | Veis_3477 | KEGG: bxe:Bxe_C1131 cystathionine beta-lyase; TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase. (393 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (512 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (380 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (425 aa) |
| | Veis_3989 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: bch:Bcen2424_5397 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (309 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: rfr:Rfer_3690 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa) |
| | Veis_4113 | PFAM: dihydrodipicolinate synthetase; KEGG: eca:ECA1002 putative dihydrodipicolinate synthase; Belongs to the DapA family. (311 aa) |
| | Veis_4134 | KEGG: bbr:BB1542 cystathionase beta-lyase; TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. (400 aa) |
| | Veis_4212 | PFAM: thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rxy:Rxyl_2271 thiamine pyrophosphate enzyme-like TPP binding region. (477 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (438 aa) |
| | Veis_4258 | TIGRFAM: serine O-acetyltransferase; KEGG: pol:Bpro_3291 serine O-acetyltransferase. (260 aa) |
| | Veis_4350 | KEGG: pol:Bpro_3605 citrate synthase I; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (436 aa) |
| | Veis_4358 | Aconitase; PFAM: aconitate hydratase domain protein; aconitate hydratase 2; KEGG: rso:RSp0332 probable aconitate hydratase 2 transmembrane protein; Belongs to the aconitase/IPM isomerase family. (863 aa) |
| | hisC | Aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: rfr:Rfer_2947 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (396 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pol:Bpro_0806 imidazoleglycerol-phosphate dehydratase. (210 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (222 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: pol:Bpro_0808 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (245 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (266 aa) |
| | Veis_4390 | PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: pol:Bpro_1422 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase. (413 aa) |
| | Veis_4426 | Methylthioadenosine nucleosidase; PFAM: purine and other phosphorylases, family 1; KEGG: ccr:CC2266 5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase. (323 aa) |
| | metE | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (789 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (252 aa) |
| | Veis_4509 | PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: hma:rrnB0209 acetolactate synthase large subunit. (560 aa) |
| | Veis_4523 | Dihydroxyacid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: pol:Bpro_5111 dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (562 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (382 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa) |
| | Veis_4677 | KEGG: rme:Rmet_4946 hypothetical protein. (257 aa) |
| | Veis_4686 | Dihydrodipicolinate synthetase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa) |
| | Veis_4712 | Serine O-acetyltransferase; PFAM: transferase hexapeptide repeat containing protein; PilT protein domain protein; KEGG: rso:RSc0871 putative plasmid stability-like protein. (209 aa) |
| | Veis_4747 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (414 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (403 aa) |
| | Veis_4847 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase; KEGG: rfr:Rfer_0669 asparagine synthase, glutamine-hydrolyzing. (584 aa) |
| | Veis_4860 | Histidine biosynthesis; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (229 aa) |
| | Veis_4861 | TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; PFAM: glutamine amidotransferase class-I; KEGG: lpf:lpl0787 amidotransferase HisH. (270 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (421 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: pol:Bpro_3615 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (256 aa) |
| | Veis_4872 | KEGG: pol:Bpro_3612 aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD - binding; Semialdehyde dehydrogenase, dimerisation region; Belongs to the aspartate-semialdehyde dehydrogenase family. (379 aa) |
| | Veis_4883 | KEGG: rfr:Rfer_1329 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase, subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase, type 3. (264 aa) |
| | Veis_4911 | Threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: pau:PA14_53260 hypothetical protein. (323 aa) |
| | Veis_4913 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: pol:Bpro_2956 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (335 aa) |
| | Veis_4940 | KEGG: rfr:Rfer_1353 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (422 aa) |
