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LP43_2444 LP43_2444 LP43_0002 LP43_0002 LP43_0180 LP43_0180 LP43_0231 LP43_0231 dnaG dnaG rnhA rnhA dnaQ dnaQ LP43_0491 LP43_0491 polA polA LP43_0635 LP43_0635 LP43_0889 LP43_0889 parA parA LP43_1293 LP43_1293 ligA ligA LP43_1477 LP43_1477 surA surA LP43_1491 LP43_1491 LP43_1533 LP43_1533 LP43_1559 LP43_1559 LP43_1656 LP43_1656 dnaX dnaX LP43_1881 LP43_1881 LP43_1887 LP43_1887 ppiC ppiC LP43_2059 LP43_2059 LP43_2223 LP43_2223 LP43_2314 LP43_2314 LP43_2433 LP43_2433 rnhB rnhB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LP43_2444DNA polymerase III epsilon subunit. (488 aa)
LP43_0002Hypothetical protein. (96 aa)
LP43_0180DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (324 aa)
LP43_0231Chromosome (plasmid) partitioning protein ParA/Sporulation initiation inhibitor protein Soj. (259 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (572 aa)
rnhARibonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (145 aa)
dnaQDNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (245 aa)
LP43_0491Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (160 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (916 aa)
LP43_0635Chromosome (plasmid) partitioning protein ParA/Sporulation initiation inhibitor protein Soj. (247 aa)
LP43_0889PhoH-like ATPase. (469 aa)
parAChromosome (plasmid) partitioning protein ParA. (262 aa)
LP43_1293Chromosome partitioning protein ParA. (251 aa)
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (673 aa)
LP43_1477Peptidyl-prolyl cis-trans isomerase ppiD. (627 aa)
surAPeptidyl-prolyl cis-trans isomerase SurA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (421 aa)
LP43_1491DNA polymerase III chi subunit. (142 aa)
LP43_1533DNA polymerase III alpha subunit. (1161 aa)
LP43_1559Tellurium resistance protein terD. (437 aa)
LP43_1656DNA polymerase III delta subunit. (339 aa)
dnaXDNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (569 aa)
LP43_1881Putative endonuclease; Belongs to the UPF0102 family. (120 aa)
LP43_1887Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (469 aa)
ppiCPeptidyl-prolyl cis-trans isomerase ppiC. (93 aa)
LP43_2059Hypothetical protein. (157 aa)
LP43_2223DNA polymerase III delta prime subunit. (326 aa)
LP43_2314DNA polymerase III epsilon subunit. (240 aa)
LP43_2433Holliday junction DNA helicase. (441 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (190 aa)
Your Current Organism:
Methylophaga thiooxydans
NCBI taxonomy Id: 392484
Other names: DSM 22068, M. thiooxydans, Methylophaga thiooxidans, Methylophaga thiooxydans corrig. Boden et al. 2011, VKM B-2586, strain DMS010
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