STRINGSTRING
Swit_2452 Swit_2452 Swit_2410 Swit_2410 Swit_2409 Swit_2409 Swit_2219 Swit_2219 Swit_2198 Swit_2198 Swit_2168 Swit_2168 ruvC ruvC ruvA ruvA ruvB ruvB xerC xerC Swit_0137 Swit_0137 Swit_0154 Swit_0154 Swit_0186 Swit_0186 xerC-2 xerC-2 Swit_0232 Swit_0232 recA recA Swit_0662 Swit_0662 Swit_0990 Swit_0990 Swit_1046 Swit_1046 Swit_1522 Swit_1522 Swit_1580 Swit_1580 Swit_1523 Swit_1523 Swit_1914 Swit_1914 Swit_4733 Swit_4733 Swit_4729 Swit_4729 recO recO Swit_4454 Swit_4454 Swit_4415 Swit_4415 Swit_4118 Swit_4118 radA radA recR recR Swit_3982 Swit_3982 ku ku Swit_3979 Swit_3979 Swit_3752 Swit_3752 Swit_3678 Swit_3678 ihfA ihfA Swit_3420 Swit_3420 Swit_3384 Swit_3384 Swit_3203 Swit_3203 Swit_2972 Swit_2972 Swit_2649 Swit_2649 Swit_2487 Swit_2487 Swit_2465 Swit_2465 Swit_2460 Swit_2460
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Swit_2452TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n. (195 aa)
Swit_2410PFAM: transposase, IS4 family protein. (270 aa)
Swit_2409Histone family protein DNA-binding protein; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (92 aa)
Swit_2219Recombinase; PFAM: Resolvase, N-terminal domain; Recombinase. (558 aa)
Swit_2198TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n. (151 aa)
Swit_2168PFAM: transposase, IS4 family protein. (270 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (165 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (199 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (342 aa)
xerCPhage integrase family protein; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (301 aa)
Swit_0137PFAM: SapC family protein. (258 aa)
Swit_0154PFAM: phage integrase family protein; Belongs to the 'phage' integrase family. (451 aa)
Swit_0186Recombinase; PFAM: Resolvase, N-terminal domain; Recombinase. (559 aa)
xerC-2Phage integrase family protein; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (308 aa)
Swit_0232PFAM: protein of unknown function DUF195. (445 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (357 aa)
Swit_0662PFAM: phage integrase family protein; Belongs to the 'phage' integrase family. (417 aa)
Swit_0990PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein. (318 aa)
Swit_1046Hypothetical protein. (801 aa)
Swit_1522PFAM: Resolvase, N-terminal domain; Recombinase. (568 aa)
Swit_1580Hypothetical protein. (303 aa)
Swit_1523Hypothetical protein. (145 aa)
Swit_1914TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like. (588 aa)
Swit_4733TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase, RecJ domain protein; phosphoesterase, DHHA1. (588 aa)
Swit_4729DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (553 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (243 aa)
Swit_4454PFAM: transposase, IS4 family protein. (270 aa)
Swit_4415PFAM: transposase, IS4 family protein. (270 aa)
Swit_4118Hypothetical protein. (104 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (455 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa)
Swit_3982TIGRFAM: DNA ligase D; DNA ligase D, 3'-phosphoesterase domain; DNA polymerase LigD, polymerase domain; DNA polymerase LigD, ligase region; PFAM: DNA primase, small subunit; ATP dependent DNA ligase domain protein; ATP dependent DNA ligase. (837 aa)
kuKu family containing protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (285 aa)
Swit_3979PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase. (532 aa)
Swit_3752PFAM: phage integrase family protein; Belongs to the 'phage' integrase family. (422 aa)
Swit_3678PFAM: protein of unknown function DUF932. (281 aa)
ihfAIntegration host factor, alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (100 aa)
Swit_3420PFAM: Resolvase, N-terminal domain; Recombinase. (689 aa)
Swit_3384PFAM: Resolvase, N-terminal domain; Recombinase. (590 aa)
Swit_3203PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein. (318 aa)
Swit_2972PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein. (318 aa)
Swit_2649PFAM: transposase, IS4 family protein. (270 aa)
Swit_2487PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein. (318 aa)
Swit_2465Hypothetical protein. (136 aa)
Swit_2460PFAM: phage integrase family protein; Belongs to the 'phage' integrase family. (593 aa)
Your Current Organism:
Sphingomonas wittichii
NCBI taxonomy Id: 392499
Other names: S. wittichii RW1, Sphingomonas sp. RW1, Sphingomonas wittichii DSM 6014, Sphingomonas wittichii RW1, Sphingomonas wittichii str. RW1, Sphingomonas wittichii strain RW1
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