STRINGSTRING
pfkA_2 pfkA_2 DapB DapB dapA dapA CtfA CtfA gpmA gpmA HQ45_01070 HQ45_01070 HQ45_01090 HQ45_01090 gcdB gcdB HQ45_01160 HQ45_01160 rpiB rpiB tkt tkt HQ45_01570 HQ45_01570 sdhA sdhA frdB frdB fhs fhs comB comB pgi pgi PgcA PgcA glyA glyA Pta Pta ackA ackA fbp fbp folD folD NrnA NrnA HQ45_03520 HQ45_03520 ppdK ppdK pgk pgk abfD abfD HQ45_03640 HQ45_03640 HQ45_03645 HQ45_03645 GlcK GlcK LysC LysC fda fda tal tal gltX gltX gapA gapA tpiA tpiA asd asd Rpe Rpe hemA hemA cysG cysG hemB hemB hemL hemL pfp pfp prs prs pckA pckA FumB FumB gdh gdh HQ45_07675 HQ45_07675 PaaH PaaH pdxH pdxH HQ45_08120 HQ45_08120 FumA FumA TtdA TtdA HQ45_08195 HQ45_08195 mutE mutE mamA mamA serC serC serA serA eno eno MaeB MaeB gltD gltD pyk pyk Mdh Mdh porC porC porB porB porA_2 porA_2 mutA mutA mutB mutB HQ45_09305 HQ45_09305 HQ45_09325 HQ45_09325 PorA_1 PorA_1 HQ45_09520 HQ45_09520 ctfB ctfB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pfkA_26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (326 aa)
DapBHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DapB family. (247 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa)
CtfABranched-chain amino acid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa)
HQ45_01070Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
HQ45_01090Biofilm PGA synthesis protein PgaD; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
gcdBglutaconyl-CoA decarboxylase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
HQ45_01160Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (322 aa)
rpiBRibose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (148 aa)
tktTransketolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the transketolase family. (677 aa)
HQ45_01570Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (646 aa)
frdBSuccinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
fhsFormate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)
comBHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ComB family. (247 aa)
pgiHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (431 aa)
PgcAPhosphoglucomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (584 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
PtaPhosphotransacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
fbpClass 3; catalyzes the formation of fructose 6-phosphate from fructose-1,6-bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (656 aa)
folD5,10-methylene-tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (300 aa)
NrnAHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)
HQ45_03520Oxaloacetate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (621 aa)
ppdKPyruvate phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family. (908 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (422 aa)
abfD4-hydroxybutyryl-CoA dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (486 aa)
HQ45_03640MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (618 aa)
HQ45_036452-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
GlcKGlucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
LysCAspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (445 aa)
fdaFructose-bisphosphate aldolase; Catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (219 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (505 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (337 aa)
RpeRibulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (218 aa)
hemAHypothetical protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (415 aa)
cysGHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (505 aa)
hemBDelta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (324 aa)
hemLGlutamate-1-semialdehyde aminotransferase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
pfpDiphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (557 aa)
prsRibose-phosphate pyrophosphokinase; Catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (536 aa)
FumBFumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (557 aa)
gdhConverts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (445 aa)
HQ45_07675Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
PaaH3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
pdxHPyridoxine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (215 aa)
HQ45_08120Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
FumAFumarate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
TtdAFumarate hydratase; Catalyzes the reversible hydration of fumaric acid to yield I-malic acid; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
HQ45_08195Methylaspartate ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (414 aa)
mutEGlutamate mutase; Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). (483 aa)
mamAMethylaspartate mutase; Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). (137 aa)
serCMFS transporter; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (356 aa)
serA3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (306 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa)
MaeBMalic enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (758 aa)
gltDDihydropyrimidine dehydrogenase; NADH-dependent; catalyzes the conversion of pyrimidines to 5,6-dihydro compounds in pyrimidine degradation; Derived by automated computational analysis using gene prediction method: Protein Homology. (489 aa)
pykPyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (474 aa)
MdhMalate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. (332 aa)
porC2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)
porB2-oxoglutarate oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
porA_22-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
mutAmethylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (625 aa)
mutBmethylmalonyl-CoA mutase; MDM; functions in conversion of succinate to propionate; Derived by automated computational analysis using gene prediction method: Protein Homology. (715 aa)
HQ45_09305CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (684 aa)
HQ45_09325uroporphyrinogen-III synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
PorA_1Racemase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1181 aa)
HQ45_09520acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
ctfBAcetate CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
Your Current Organism:
Porphyromonas crevioricanis
NCBI taxonomy Id: 393921
Other names: ATCC 55563, CCUG 47702 [[Porphyromonas cansulci]], JCM 13913 [[Porphyromonas cansulci]], JCM 15906, NCTC 12858 [[Porphyromonas cansulci]], NUM 402, P. crevioricanis, Porphyromonas cansulci, VPB 4875 [[Porphyromonas cansulci]]
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.