STRINGSTRING
ACP23932.1 ACP23932.1 purU4 purU4 gpt gpt ACP25285.1 ACP25285.1 carB carB coaD coaD ACP25354.1 ACP25354.1 purC purC purS purS purQ purQ purL purL ACP25511.1 ACP25511.1 ACP25558.1 ACP25558.1 ACP25559.1 ACP25559.1 ACP25636.1 ACP25636.1 pfp pfp carA carA prsA prsA apt apt ACP26234.1 ACP26234.1 ACP26285.1 ACP26285.1 ACP26380.1 ACP26380.1 ACP26394.1 ACP26394.1 ACP26425.1 ACP26425.1 ACP26448.1 ACP26448.1 accA accA purA purA ACP26552.1 ACP26552.1 pgk pgk fbaB fbaB purE purE purK purK ACP26581.1 ACP26581.1 ACP26631.1 ACP26631.1 ACP26698.1 ACP26698.1 bkdB bkdB purU3 purU3 atpC atpC atpD atpD atpG atpG atpA atpA atpH atpH sucB2 sucB2 sucA sucA ACP26886.1 ACP26886.1 ACP26890.1 ACP26890.1 rppH rppH purH purH ascA ascA ACP27067.1 ACP27067.1 coaE coaE accD accD coaA coaA upp upp deoB deoB glk glk gpmA gpmA guaA guaA pyrF pyrF ACP27428.1 ACP27428.1 pyrG pyrG ACP25047.1 ACP25047.1 adk-2 adk-2 ACP24909.1 ACP24909.1 accB accB pyrB pyrB purM purM purN purN ACP24718.1 ACP24718.1 ndk ndk gmk gmk purF purF ACP24615.1 ACP24615.1 amn amn cbbT cbbT pgi-2 pgi-2 adk adk gpmB gpmB ACP24306.1 ACP24306.1 purD purD atpF1 atpF1 atpF2 atpF2 atpE atpE atpB atpB ribF ribF guaB guaB ACP24140.1 ACP24140.1 acsA acsA fliI fliI pyrD pyrD ACP23944.1 ACP23944.1 pgi pgi pyrC pyrC pyrE pyrE surE surE pyrH pyrH MazG MazG ACP25072.1 ACP25072.1 ACP25066.1 ACP25066.1 pdhB3 pdhB3 eno eno
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ACP23932.1Hypothetical protein. (97 aa)
purU4Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
gptXanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (165 aa)
ACP25285.1Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa)
carBCarbamoyl-phosphate synthetase ammonia chain; Belongs to the CarB family. (1163 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa)
ACP25354.1Hypothetical protein. (259 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) PurC. (254 aa)
purSPhosphoribosylformylglycinamidine synthase PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assis [...] (80 aa)
purQPhosphoribosylformylglycinamidine synthase I (FGAMsynthase I) PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and [...] (223 aa)
purLPhosphoribosylformylglycinamidine synthase II (FGAMsynthase II) PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL an [...] (742 aa)
ACP25511.1Predicted acyl-CoA hydrolase protein. (128 aa)
ACP25558.1Hypothetical protein. (144 aa)
ACP25559.1Glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein. (115 aa)
ACP25636.1Probable regulatory protein. (292 aa)
pfpPyrophosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (404 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (401 aa)
prsARibose-phosphate pyrophosphokinase, PrsA; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (335 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (214 aa)
ACP26234.1Dihydropyrimidine dehydrogenase. (437 aa)
ACP26285.1Glyoxalase/bleomycin resistance protein/dioxygenase. (317 aa)
ACP26380.1Putative citrate lyase; Belongs to the HpcH/HpaI aldolase family. (313 aa)
ACP26394.1Adenylosuccinate lyase. (445 aa)
ACP26425.1acetyl-CoA synthetase. (549 aa)
ACP26448.1Putative hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa)
accAacetyl-CoA carboxylase, alpha subunit, AccA; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
ACP26552.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (658 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa)
fbaBFructose-bisphosphate aldolase. (341 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (166 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (349 aa)
ACP26581.1Pyruvate kinase; Belongs to the pyruvate kinase family. (479 aa)
ACP26631.1Putative glyoxylase. (253 aa)
ACP26698.1Hypothetical protein. (125 aa)
bkdBDihydrolipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex. (426 aa)
purU3Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
atpCATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (134 aa)
atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (505 aa)
atpGATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (293 aa)
atpAATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (509 aa)
atpHATP synthase F1, delta chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (188 aa)
sucB2Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (413 aa)
sucA2-oxoglutarate dehydrogenase, E1 component. (998 aa)
ACP26886.1acyl-CoA thioesterase. (294 aa)
ACP26890.1Citrate lyase, beta subunit; Belongs to the HpcH/HpaI aldolase family. (313 aa)
rppHPredicted (Di)nucleoside polyphosphate hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (175 aa)
purHBifunctional purine biosynthesis protein PurH;includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase. (536 aa)
ascAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa)
ACP27067.1AMP-dependent synthetase and ligase. (635 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (194 aa)
accDacetyl-CoA carboxylase carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (304 aa)
coaAPantothenate kinase. (331 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (406 aa)
glkGlucokinase (glucose kinase) protein, Glk; Belongs to the bacterial glucokinase family. (339 aa)
gpmAPhosphoglycerate mutase 1 family protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (211 aa)
guaAGlutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. (520 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (234 aa)
ACP27428.1Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (550 aa)
ACP25047.1Hypothetical protein; Belongs to the HpcH/HpaI aldolase family. (237 aa)
adk-2Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (192 aa)
ACP24909.1Hypothetical protein. (107 aa)
accBacetyl-CoA carboxylase, biotin carboxylase protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (313 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; AIRS; Phosphoribosyl-aminoimidazole synthetase; AIR synthase. (356 aa)
purNPutative 5'-phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (221 aa)
ACP24718.1Hypothetical protein. (198 aa)
ndkPutative nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (219 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (496 aa)
ACP24615.1GTP pyrophosphohydrolase/synthetase, RelA/SpoT family; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (741 aa)
amnAMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (500 aa)
cbbTTransketolase I; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa)
pgi-2Glucose-6-phosphate isomerase; Belongs to the GPI family. (541 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (194 aa)
gpmBPhosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (194 aa)
ACP24306.1Hypothetical protein. (52 aa)
purDPhosphoribosylamine--glycine ligase; GARS; glycinamideribonucleotide synthetase; phosphoribosylglycinamide synthetase; Belongs to the GARS family. (423 aa)
atpF1Fo ATP synthase B chain; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (161 aa)
atpF2FoF1 ATP synthase subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (203 aa)
atpEATP synthase, subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (75 aa)
atpBATP synthase A chain; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (250 aa)
ribFRiboflavin biosynthesis protein RibF. (356 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (514 aa)
ACP24140.1Putative acyl-CoA thioester hydrolase. (167 aa)
acsAAcetoacetyl-coenzyme A synthetase. (650 aa)
fliIFlagellum-specific ATP synthase. (466 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (362 aa)
ACP23944.1Conserved hypothetical protein contains a predicted polyphosphate kinase 2 domain. (300 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (541 aa)
pyrCDihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (345 aa)
pyrEOrotate phosphoribosyl transferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (232 aa)
surE5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (288 aa)
MazGPutative MazG family protein. (277 aa)
ACP25072.1Putative DNA topology modulation FlaR protein. (187 aa)
ACP25066.1Dihydrolipoyllysine-residue acetyltransferase component of pyruvatedehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (447 aa)
pdhB3Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (455 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa)
Your Current Organism:
Sinorhizobium fredii NGR234
NCBI taxonomy Id: 394
Other names: Ensifer fredii NGR234, Plasmid pNGR234a, Rhizobium sp. (strain NGR234), Rhizobium sp. NGR234, S. fredii NGR234, Sinorhizobium sp. NGR234
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