STRINGSTRING
DHH DHH NODAL NODAL APC APC GLI2 GLI2 OLIG3 OLIG3 HOXC10 HOXC10 SMO SMO TLX3 TLX3 SIX2 SIX2 FOXA1 FOXA1 TBX6 TBX6 TBX4 TBX4 TEAD4 TEAD4 SFRP2 SFRP2 DMRTA2 DMRTA2 FOXA2 FOXA2 NOTCH1 NOTCH1 DLL1 DLL1 TBX20 TBX20 TENM4 TENM4 HOXA13 HOXA13 CDON CDON MYL10 MYL10 PSEN1 PSEN1 PRDM14 PRDM14 TBXT TBXT MGA MGA EYA1 EYA1 TBX22 TBX22 TBX2 TBX2 APC2 APC2 EHMT2 EHMT2 HOXD10 HOXD10 GLI3 GLI3 HOXA11 HOXA11 POU4F1 POU4F1 ENSSBOP00000005807 ENSSBOP00000005807 ETV2 ETV2 GSC GSC ATOH1 ATOH1 IHH IHH ENSSBOP00000003654 ENSSBOP00000003654 PAX6 PAX6 TBX1 TBX1 ENSSBOP00000034475 ENSSBOP00000034475 OLIG2 OLIG2 NKX2-2 NKX2-2 NRP1 NRP1 FEV FEV SOX9 SOX9 TBX15 TBX15 TBX18 TBX18 PAX2 PAX2 LHX3 LHX3 TBR1 TBR1 ISL2 ISL2 TBX19 TBX19 MYT1L MYT1L ISL1 ISL1 TBX3 TBX3 CTNNB1 CTNNB1 PTCH2 PTCH2 EOMES EOMES DBX1 DBX1 TBX21 TBX21 TBX5 TBX5 EYA2 EYA2 FKBP8 FKBP8 MYL2 MYL2 DMRT3 DMRT3 TBX10 TBX10 SUFU SUFU PTCH1 PTCH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
NODALNodal growth differentiation factor. (347 aa)
APCAPC regulator of WNT signaling pathway. (2843 aa)
GLI2GLI family zinc finger 2. (1564 aa)
OLIG3Oligodendrocyte transcription factor 3. (263 aa)
HOXC10Homeobox C10. (342 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (775 aa)
TLX3T cell leukemia homeobox 3. (291 aa)
SIX2SIX homeobox 2. (291 aa)
FOXA1Forkhead box A1. (459 aa)
TBX6T-box transcription factor 6. (436 aa)
TBX4T-box transcription factor 4. (583 aa)
TEAD4TEA domain transcription factor 4. (391 aa)
SFRP2Secreted frizzled related protein 2. (296 aa)
DMRTA2DMRT like family A2. (385 aa)
FOXA2Forkhead box A2. (451 aa)
NOTCH1Notch receptor 1. (2538 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
TBX20T-box transcription factor 20. (446 aa)
TENM4Teneurin transmembrane protein 4. (2864 aa)
HOXA13Homeobox A13. (204 aa)
CDONCell adhesion associated, oncogene regulated. (1264 aa)
MYL10Myosin light chain 10. (230 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
PRDM14PR/SET domain 14. (469 aa)
TBXTT-box transcription factor T. (434 aa)
MGAMAX dimerization protein MGA. (3067 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
TBX22Uncharacterized protein. (501 aa)
TBX2T-box transcription factor 2. (633 aa)
APC2APC regulator of WNT signaling pathway 2. (1873 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1267 aa)
HOXD10Homeobox D10. (340 aa)
GLI3GLI family zinc finger 3. (1577 aa)
HOXA11Homeobox A11. (313 aa)
POU4F1POU domain protein. (239 aa)
ENSSBOP00000005807HH_signal domain-containing protein. (115 aa)
ETV2ETS variant 2. (367 aa)
GSCGoosecoid homeobox. (257 aa)
ATOH1Atonal bHLH transcription factor 1. (355 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
ENSSBOP00000003654Homeobox domain-containing protein. (221 aa)
PAX6Paired box 6. (488 aa)
TBX1Uncharacterized protein. (314 aa)
ENSSBOP00000034475Uncharacterized protein. (143 aa)
OLIG2Oligodendrocyte transcription factor 2. (202 aa)
NKX2-2NK2 homeobox 2. (402 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
FEVFEV transcription factor, ETS family member. (172 aa)
SOX9SRY-box transcription factor 9. (452 aa)
TBX15T-box transcription factor 15. (627 aa)
TBX18T-box transcription factor 18. (607 aa)
PAX2Paired box 2. (447 aa)
LHX3LIM homeobox 3. (397 aa)
TBR1T-box brain transcription factor 1. (682 aa)
ISL2ISL LIM homeobox 2. (359 aa)
TBX19T-box transcription factor 19. (448 aa)
MYT1LMyelin transcription factor 1 like. (1187 aa)
ISL1ISL LIM homeobox 1. (349 aa)
TBX3T-box transcription factor 3. (743 aa)
CTNNB1Catenin beta 1. (781 aa)
PTCH2Patched 2. (1160 aa)
EOMESEomesodermin. (706 aa)
DBX1Developing brain homeobox 1. (346 aa)
TBX21T-box transcription factor 21. (535 aa)
TBX5T-box transcription factor 5. (518 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (507 aa)
FKBP8Peptidylprolyl isomerase. (444 aa)
MYL2Myosin light chain 2. (165 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (350 aa)
TBX10T-box transcription factor 10. (383 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (524 aa)
PTCH1Patched 1. (1440 aa)
Your Current Organism:
Saimiri boliviensis
NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis
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