(93 nodes) Endoplasmic reticulum organization network (Saimiri boliviensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RETREG1	Reticulophagy regulator 1. (413 aa)
	TRDN	Triadin. (598 aa)
	TMEM33	Transmembrane protein 33. (247 aa)
	ATL3	Atlastin GTPase 3. (540 aa)
	EMC7	ER membrane protein complex subunit 7. (241 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1880 aa)
	EMC3	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (261 aa)
	ENSSBOP00000003833	Uncharacterized protein. (551 aa)
	ENSSBOP00000004488	Uncharacterized protein. (212 aa)
	TMEM170A	Transmembrane protein 170A. (118 aa)
	EMC6	ER membrane protein complex subunit 6. (110 aa)
	UBL4B	Ubiquitin like 4B. (174 aa)
	TRAM1L1	Translocating chain-associated membrane protein; Belongs to the TRAM family. (369 aa)
	PCNX4	Pecanex 4. (1174 aa)
	SPTSSB	Serine palmitoyltransferase small subunit B. (76 aa)
	ZFYVE27	Zinc finger FYVE-type containing 27. (416 aa)
	PCNX3	Pecanex 3. (2034 aa)
	REEP6	Receptor expression-enhancing protein. (172 aa)
	GET1	Guided entry of tail-anchored proteins factor 1. (174 aa)
	MMGT1	Membrane magnesium transporter 1. (131 aa)
	EMC2	ER membrane protein complex subunit 2. (297 aa)
	LMAN1L	Lectin, mannose binding 1 like. (525 aa)
	TOR1AIP2	Torsin 1A interacting protein 2. (470 aa)
	ENSSBOP00000010157	TPR_REGION domain-containing protein. (639 aa)
	PCNX1	Pecanex 1. (2281 aa)
	ATL1	Atlastin GTPase 1. (558 aa)
	SEC16B	Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (1059 aa)
	TOR1B	Torsin family 1 member B. (303 aa)
	VAPB	VAMP associated protein B and C. (243 aa)
	LNPK	Lunapark, ER junction formation factor. (459 aa)
	CAV2	Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
	EMC9	ER membrane protein complex subunit 9. (232 aa)
	LMAN2	Lectin, mannose binding 2. (358 aa)
	SEC31B	SEC31 homolog B, COPII coat complex component. (1181 aa)
	EMC1	ER membrane protein complex subunit 1. (1032 aa)
	RNF112	Ring finger protein 112. (631 aa)
	ESYT3	Extended synaptotagmin 3. (890 aa)
	LRRK2	Leucine rich repeat kinase 2. (2528 aa)
	CXorf56	Chromosome X open reading frame 56. (208 aa)
	DOP1A	DOP1 leucine zipper like protein A. (2475 aa)
	MOSPD3	Motile sperm domain containing 3. (235 aa)
	ENSSBOP00000017316	Uncharacterized protein. (167 aa)
	CAMLG	Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (295 aa)
	GET4	Guided entry of tail-anchored proteins factor 4. (274 aa)
	ARL6IP1	Uncharacterized protein. (203 aa)
	LPCAT3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (487 aa)
	RETREG3	Reticulophagy regulator family member 3. (466 aa)
	SEC16A	SEC16 homolog A, endoplasmic reticulum export factor. (2353 aa)
	GAK	Cyclin G associated kinase. (1311 aa)
	REEP1	Receptor expression-enhancing protein. (277 aa)
	TMEM38A	Transmembrane protein 38A. (292 aa)
	TMEM38B	Transmembrane protein 38B. (291 aa)
	ESYT2	Extended synaptotagmin 2. (735 aa)
	REEP3	Receptor expression-enhancing protein. (266 aa)
	ENSSBOP00000021748	Uncharacterized protein. (119 aa)
	ATL2	Atlastin GTPase 2. (583 aa)
	REEP5	Receptor expression-enhancing protein. (191 aa)
	BAG6	BCL2 associated athanogene 6. (1129 aa)
	WDR83OS	WD repeat domain 83 opposite strand. (106 aa)
	BNIP1	BCL2 interacting protein 1. (269 aa)
	UMOD	Uromodulin. (641 aa)
	TRAM1	Translocation associated membrane protein 1. (288 aa)
	VCPIP1	Valosin containing protein interacting protein 1. (1222 aa)
	EMC8	ER membrane protein complex subunit 8. (210 aa)
	UBL4A	Ubiquitin like 4A. (177 aa)
	EMC10	ER membrane protein complex subunit 10. (359 aa)
	RTN4	Reticulon. (1125 aa)
	ENSSBOP00000031972	Uncharacterized protein. (194 aa)
	SEC61A1	SEC61 translocon alpha 1 subunit. (476 aa)
	C16orf74	Chromosome 16 open reading frame 74. (76 aa)
	SGTA	Small glutamine rich tetratricopeptide repeat containing alpha. (313 aa)
	LMAN1	Lectin, mannose binding 1. (515 aa)
	TMCC1	Transmembrane and coiled-coil domain family 1. (653 aa)
	CCDC47	Coiled-coil domain containing 47. (483 aa)
	TRAM2	Translocating chain-associated membrane protein; Belongs to the TRAM family. (370 aa)
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (393 aa)
	RETREG2	Reticulophagy regulator family member 2. (449 aa)
	EMC4	ER membrane protein complex subunit 4; Belongs to the EMC4 family. (183 aa)
	RTN3	Reticulon. (981 aa)
	PCNX2	Pecanex 2. (2155 aa)
	POLR2M	RNA polymerase II subunit M. (369 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1088 aa)
	GET3	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] (348 aa)
	RAB10	RAB10, member RAS oncogene family. (200 aa)
	DOP1B	DOP1 leucine zipper like protein B. (2074 aa)
	MAPK15	Mitogen-activated protein kinase. (540 aa)
	TLE6	TLE family member 6, subcortical maternal complex member. (560 aa)
	GRAMD2A	GRAM domain containing 2A. (299 aa)
	REEP2	Receptor expression-enhancing protein. (254 aa)
	SHTN1	Shootin 1. (631 aa)
	ESYT1	Extended synaptotagmin 1. (976 aa)
	TMED2	Transmembrane p24 trafficking protein 2. (208 aa)
	JAGN1	Jagunal homolog 1. (183 aa)

Your Current Organism:

Saimiri boliviensis

NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL6IP1	SEC61A1	ENSSBOP00000018614	ENSSBOP00000032010	Uncharacterized protein.	SEC61 translocon alpha 1 subunit.	0.742
ARL6IP1	UBL4A	ENSSBOP00000018614	ENSSBOP00000027947	Uncharacterized protein.	Ubiquitin like 4A.	0.477
ARL6IP1	UBL4B	ENSSBOP00000018614	ENSSBOP00000005283	Uncharacterized protein.	Ubiquitin like 4B.	0.477
ATL1	REEP1	ENSSBOP00000010319	ENSSBOP00000020115	Atlastin GTPase 1.	Receptor expression-enhancing protein.	0.615
ATL1	REEP2	ENSSBOP00000010319	ENSSBOP00000037317	Atlastin GTPase 1.	Receptor expression-enhancing protein.	0.572
ATL1	RTN3	ENSSBOP00000010319	ENSSBOP00000034331	Atlastin GTPase 1.	Reticulon.	0.539
ATL1	RTN4	ENSSBOP00000010319	ENSSBOP00000031641	Atlastin GTPase 1.	Reticulon.	0.508
ATL1	ZFYVE27	ENSSBOP00000010319	ENSSBOP00000006036	Atlastin GTPase 1.	Zinc finger FYVE-type containing 27.	0.419
ATL2	REEP1	ENSSBOP00000023110	ENSSBOP00000020115	Atlastin GTPase 2.	Receptor expression-enhancing protein.	0.584
ATL2	RTN3	ENSSBOP00000023110	ENSSBOP00000034331	Atlastin GTPase 2.	Reticulon.	0.530
ATL2	RTN4	ENSSBOP00000023110	ENSSBOP00000031641	Atlastin GTPase 2.	Reticulon.	0.445
ATL3	REEP1	ENSSBOP00000000345	ENSSBOP00000020115	Atlastin GTPase 3.	Receptor expression-enhancing protein.	0.584
ATL3	REEP2	ENSSBOP00000000345	ENSSBOP00000037317	Atlastin GTPase 3.	Receptor expression-enhancing protein.	0.408
ATL3	RETREG1	ENSSBOP00000000345	ENSSBOP00000003172	Atlastin GTPase 3.	Reticulophagy regulator 1.	0.440
ATL3	RTN3	ENSSBOP00000000345	ENSSBOP00000034331	Atlastin GTPase 3.	Reticulon.	0.619
ATL3	RTN4	ENSSBOP00000000345	ENSSBOP00000031641	Atlastin GTPase 3.	Reticulon.	0.536
ATL3	VAPB	ENSSBOP00000000345	ENSSBOP00000012442	Atlastin GTPase 3.	VAMP associated protein B and C.	0.517
BAG6	GET3	ENSSBOP00000024052	ENSSBOP00000036036	BCL2 associated athanogene 6.	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.789
BAG6	GET4	ENSSBOP00000024052	ENSSBOP00000018115	BCL2 associated athanogene 6.	Guided entry of tail-anchored proteins factor 4.	0.986
BAG6	SGTA	ENSSBOP00000024052	ENSSBOP00000032456	BCL2 associated athanogene 6.	Small glutamine rich tetratricopeptide repeat containing alpha.	0.895