(73 nodes) Transcription repressor complex network (Saimiri boliviensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSSBOP00000011262	Uncharacterized protein. (147 aa)
	DDX20	DEAD-box helicase 20. (824 aa)
	PRDM16	PR/SET domain 16. (1183 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
	DRAP1	DR1 associated protein 1. (205 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
	SDR16C5	Short chain dehydrogenase/reductase family 16C member 5. (265 aa)
	GATA1	GATA binding protein 1. (413 aa)
	ENSSBOP00000006983	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (474 aa)
	GLI3	GLI family zinc finger 3. (1577 aa)
	INSM2	INSM transcriptional repressor 2. (514 aa)
	AKIRIN2	Akirin 2. (203 aa)
	DR1	Down-regulator of transcription 1. (176 aa)
	SKI	SKI proto-oncogene. (637 aa)
	SP1	Sp1 transcription factor. (726 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	ENSSBOP00000012177	Uncharacterized protein. (651 aa)
	ZFPM1	Uncharacterized protein. (146 aa)
	ENSSBOP00000013190	Uncharacterized protein. (198 aa)
	RLIM	Ring finger protein, LIM domain interacting. (561 aa)
	PHF12	PHD finger protein 12. (1004 aa)
	MIER1	MIER1 transcriptional regulator. (562 aa)
	MXD1	MAX dimerization protein 1. (221 aa)
	GPS2	G protein pathway suppressor 2. (329 aa)
	CORO2A	Coronin; Belongs to the WD repeat coronin family. (524 aa)
	PASD1	PAS domain containing repressor 1. (752 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	ENSSBOP00000018231	2-Hacid_dh_C domain-containing protein. (370 aa)
	MYC	MYC proto-oncogene, bHLH transcription factor. (520 aa)
	RBBP8	SAE2 domain-containing protein. (75 aa)
	CBX5	Chromobox 5. (191 aa)
	LIN37	Uncharacterized protein. (236 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (514 aa)
	NCOR2	Nuclear receptor corepressor 2. (2508 aa)
	HOXC9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1090 aa)
	SIN3A	SIN3 transcription regulator family member A. (1273 aa)
	ENSSBOP00000021549	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
	ELANE	Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (265 aa)
	MEN1	Menin 1. (610 aa)
	ARID4A	AT-rich interaction domain 4A. (1257 aa)
	ZNF350	Zinc finger protein 350. (458 aa)
	ENSSBOP00000022724	Uncharacterized protein. (515 aa)
	RCOR1	REST corepressor 1. (464 aa)
	SPEN	Spen family transcriptional repressor. (3542 aa)
	TFAP4	Transcription factor AP-4. (308 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	ENSSBOP00000026990	Uncharacterized protein. (850 aa)
	LIN54	Lin-54 DREAM MuvB core complex component. (749 aa)
	TBX18	T-box transcription factor 18. (607 aa)
	TBX15	T-box transcription factor 15. (627 aa)
	ENSSBOP00000028878	Uncharacterized protein. (111 aa)
	JAZF1	JAZF zinc finger 1. (243 aa)
	GFI1	Growth factor independent 1 transcriptional repressor. (422 aa)
	CDX2	Caudal type homeobox 2. (311 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	MAX	MYC associated factor X. (160 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	REST	RE1 silencing transcription factor. (1110 aa)
	RELB	RELB proto-oncogene, NF-kB subunit. (579 aa)
	DEPDC1	DEP domain containing 1. (812 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (673 aa)
	NCOR1	Nuclear receptor corepressor 1. (2438 aa)
	CTBP2	C-terminal binding protein 2. (990 aa)
	LIN9	Lin-9 DREAM MuvB core complex component. (570 aa)
	LIN52	Lin-52 DREAM MuvB core complex component. (116 aa)
	GMNN	Geminin DNA replication inhibitor. (204 aa)
	HDGF	Heparin binding growth factor. (256 aa)
	SP3	Sp3 transcription factor. (720 aa)
	ENSSBOP00000039148	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (392 aa)
	BIN1	Bridging integrator 1. (671 aa)
	MDM4	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)

Your Current Organism:

Saimiri boliviensis

NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID4A	ENSSBOP00000021549	ENSSBOP00000021872	ENSSBOP00000021549	AT-rich interaction domain 4A.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.893
ARID4A	ENSSBOP00000039148	ENSSBOP00000021872	ENSSBOP00000039148	AT-rich interaction domain 4A.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.893
ARID4A	HDAC1	ENSSBOP00000021872	ENSSBOP00000018138	AT-rich interaction domain 4A.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.893
ARID4A	HDAC3	ENSSBOP00000021872	ENSSBOP00000015842	AT-rich interaction domain 4A.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.893
ARID4A	HDAC4	ENSSBOP00000021872	ENSSBOP00000021361	AT-rich interaction domain 4A.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.793
ARID4A	PHF12	ENSSBOP00000021872	ENSSBOP00000013794	AT-rich interaction domain 4A.	PHD finger protein 12.	0.918
ARID4A	RCOR1	ENSSBOP00000021872	ENSSBOP00000022941	AT-rich interaction domain 4A.	REST corepressor 1.	0.690
ARID4A	SIN3A	ENSSBOP00000021872	ENSSBOP00000021519	AT-rich interaction domain 4A.	SIN3 transcription regulator family member A.	0.940
BIN1	MAX	ENSSBOP00000039565	ENSSBOP00000031610	Bridging integrator 1.	MYC associated factor X.	0.438
BIN1	MXD1	ENSSBOP00000039565	ENSSBOP00000014425	Bridging integrator 1.	MAX dimerization protein 1.	0.438
BIN1	MYC	ENSSBOP00000039565	ENSSBOP00000018378	Bridging integrator 1.	MYC proto-oncogene, bHLH transcription factor.	0.623
CBX5	MAX	ENSSBOP00000019114	ENSSBOP00000031610	Chromobox 5.	MYC associated factor X.	0.436
CCND1	CTNNB1	ENSSBOP00000030887	ENSSBOP00000025816	Cyclin D1; Belongs to the cyclin family.	Catenin beta 1.	0.638
CCND1	ENSSBOP00000021549	ENSSBOP00000030887	ENSSBOP00000021549	Cyclin D1; Belongs to the cyclin family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.462
CCND1	ENSSBOP00000039148	ENSSBOP00000030887	ENSSBOP00000039148	Cyclin D1; Belongs to the cyclin family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.462
CCND1	HDAC1	ENSSBOP00000030887	ENSSBOP00000018138	Cyclin D1; Belongs to the cyclin family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.462
CCND1	HDAC3	ENSSBOP00000030887	ENSSBOP00000015842	Cyclin D1; Belongs to the cyclin family.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.708
CCND1	HDAC4	ENSSBOP00000030887	ENSSBOP00000021361	Cyclin D1; Belongs to the cyclin family.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.654
CCND1	MDM2	ENSSBOP00000030887	ENSSBOP00000003261	Cyclin D1; Belongs to the cyclin family.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.544
CCND1	MYC	ENSSBOP00000030887	ENSSBOP00000018378	Cyclin D1; Belongs to the cyclin family.	MYC proto-oncogene, bHLH transcription factor.	0.528