STRINGSTRING
ONECUT2 ONECUT2 SPRED2 SPRED2 BRMS1L BRMS1L BMP2 BMP2 ZBTB7A ZBTB7A STRAP STRAP SNX25 SNX25 PMEPA1 PMEPA1 BCL9L BCL9L ING1 ING1 HTRA3 HTRA3 SPRY1 SPRY1 RASL11B RASL11B ENG ENG SKOR2 SKOR2 SAP30L SAP30L ARID4B ARID4B CD109 CD109 ADAMTSL2 ADAMTSL2 SKI SKI ASPN ASPN PIN1 PIN1 SLC2A10 SLC2A10 TGFB1I1 TGFB1I1 DNM2 DNM2 BAMBI BAMBI ENSSBOP00000011071 ENSSBOP00000011071 OGT OGT SMURF2 SMURF2 HTRA4 HTRA4 HSPA5 HSPA5 HTRA1 HTRA1 WFIKKN1 WFIKKN1 CAV2 CAV2 EMILIN1 EMILIN1 LDLRAD4 LDLRAD4 WNT1 WNT1 ENSSBOP00000015862 ENSSBOP00000015862 PRDM16 PRDM16 PDPK1 PDPK1 STUB1 STUB1 FBN1 FBN1 MTMR4 MTMR4 IL17RD IL17RD HDAC2 HDAC2 PPARA PPARA SMURF1 SMURF1 SIN3A SIN3A SPINT3 SPINT3 VEPH1 VEPH1 DAND5 DAND5 ENSSBOP00000023005 ENSSBOP00000023005 ENSSBOP00000023518 ENSSBOP00000023518 ING2 ING2 SAP30 SAP30 SMAD7 SMAD7 SKIL SKIL CAV1 CAV1 ENSSBOP00000026820 ENSSBOP00000026820 SAP130 SAP130 XBP1 XBP1 NRROS NRROS NKX2-1 NKX2-1 CHST11 CHST11 SPRED1 SPRED1 TGFB3 TGFB3 WFIKKN2 WFIKKN2 PBLD PBLD PPM1A PPM1A TET1 TET1 FBN2 FBN2 SIRT1 SIRT1 SPRED3 SPRED3 ZNF451 ZNF451 TGFBR3 TGFBR3 ENSSBOP00000037087 ENSSBOP00000037087 FAM89B FAM89B LEMD3 LEMD3 ADAM17 ADAM17 CIDEA CIDEA GLG1 GLG1 SPRY2 SPRY2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ONECUT2One cut domain family member. (294 aa)
SPRED2Sprouty related EVH1 domain containing 2. (432 aa)
BRMS1LBRMS1 like transcriptional repressor. (323 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (529 aa)
STRAPSerine/threonine kinase receptor associated protein. (363 aa)
SNX25Sorting nexin 25. (840 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (252 aa)
BCL9LBCL9 like. (1496 aa)
ING1Inhibitor of growth protein. (365 aa)
HTRA3HtrA serine peptidase 3. (439 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
RASL11BRAS like family 11 member B. (248 aa)
ENGEndoglin. (655 aa)
SKOR2c-SKI_SMAD_bind domain-containing protein. (296 aa)
SAP30LSAP30 like. (182 aa)
ARID4BAT-rich interaction domain 4B. (1092 aa)
CD109CD109 molecule. (1449 aa)
ADAMTSL2ADAMTS like 2. (1042 aa)
SKISKI proto-oncogene. (637 aa)
ASPNAsporin. (374 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (175 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (637 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
BAMBIBMP and activin membrane bound inhibitor. (218 aa)
ENSSBOP00000011071MH2 domain-containing protein. (232 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (988 aa)
SMURF2E3 ubiquitin-protein ligase. (738 aa)
HTRA4HtrA serine peptidase 4. (414 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
HTRA1HtrA serine peptidase 1. (423 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (545 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ENSSBOP00000015862C2H2-type domain-containing protein. (446 aa)
PRDM16PR/SET domain 16. (1183 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (555 aa)
STUB1STIP1 homology and U-box containing protein 1. (250 aa)
FBN1Fibrillin 1. (2872 aa)
MTMR4Myotubularin related protein 4. (1208 aa)
IL17RDInterleukin 17 receptor D. (739 aa)
HDAC2Hist_deacetyl domain-containing protein. (314 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
SMURF1E3 ubiquitin-protein ligase. (745 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
SPINT3Serine peptidase inhibitor, Kunitz type 3. (89 aa)
VEPH1Ventricular zone expressed PH domain containing 1. (833 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
ENSSBOP00000023005Uncharacterized protein. (465 aa)
ENSSBOP00000023518WD_REPEATS_REGION domain-containing protein. (292 aa)
ING2Inhibitor of growth protein. (279 aa)
SAP30Sin3A associated protein 30. (124 aa)
SMAD7Mothers against decapentaplegic homolog. (492 aa)
SKILSKI like proto-oncogene. (651 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (147 aa)
ENSSBOP00000026820Uncharacterized protein. (293 aa)
SAP130Sin3A associated protein 130. (1083 aa)
XBP1BZIP domain-containing protein. (375 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
NKX2-1NK2 homeobox 1. (402 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (576 aa)
PBLDPhenazine biosynthesis like protein domain containing. (288 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
TET1Tet methylcytosine dioxygenase 1. (2088 aa)
FBN2Fibrillin 2. (2912 aa)
SIRT1Sirtuin 1. (453 aa)
SPRED3Sprouty related EVH1 domain containing 3. (430 aa)
ZNF451Uncharacterized protein. (1073 aa)
TGFBR3Transforming growth factor beta receptor 3. (914 aa)
ENSSBOP00000037087Hist_deacetyl domain-containing protein. (226 aa)
FAM89BFamily with sequence similarity 89 member B. (119 aa)
LEMD3LEM domain containing 3. (924 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
CIDEACell death inducing DFFA like effector a. (219 aa)
GLG1Golgi glycoprotein 1. (1101 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
Your Current Organism:
Saimiri boliviensis
NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.