STRINGSTRING
NHLRC2 NHLRC2 ENSSBOP00000005101 ENSSBOP00000005101 VCL VCL ENSSBOP00000005360 ENSSBOP00000005360 SRGN SRGN ENSSBOP00000005829 ENSSBOP00000005829 PSMA2 PSMA2 SLPI SLPI BIN2 BIN2 HUWE1 HUWE1 F5 F5 GIP GIP GNS GNS FABP5 FABP5 TXNDC5 TXNDC5 PRSS57 PRSS57 PA2G4 PA2G4 ACTR10 ACTR10 A1BG A1BG PNP PNP VPS13A VPS13A ENSSBOP00000009224 ENSSBOP00000009224 FERMT3 FERMT3 EPX EPX DSN1 DSN1 SERPING1 SERPING1 S100A8 S100A8 HGF HGF GMFG GMFG VEGFD VEGFD CTSH CTSH ALOX5 ALOX5 OSCAR OSCAR AOC1 AOC1 GGH GGH COMMD9 COMMD9 LRRC7 LRRC7 DERA DERA IGF2 IGF2 PRG3 PRG3 CHIT1 CHIT1 F8 F8 SERPINF2 SERPINF2 GSDMD GSDMD PSMD6 PSMD6 IMPDH IMPDH JUP JUP GHRL GHRL PSMC3 PSMC3 PYGL PYGL GAS6 GAS6 HEXB HEXB FGG FGG ENSSBOP00000002902 ENSSBOP00000002902 AGL AGL S100Z S100Z PSMD13 PSMD13 AZU1 AZU1 CTSW CTSW TGFB1 TGFB1 CYFIP1 CYFIP1 OSTF1 OSTF1 TEX264 TEX264 CDA CDA ENSSBOP00000022111 ENSSBOP00000022111 SPTAN1 SPTAN1 ACAA1 ACAA1 S100P S100P NFKB1 NFKB1 SERPINE1 SERPINE1 OLFM4 OLFM4 ENSSBOP00000022867 ENSSBOP00000022867 PSMD11 PSMD11 DBNL DBNL GRN GRN GRP GRP PSMB7 PSMB7 TIMP2 TIMP2 RAB27A RAB27A MAPK1 MAPK1 GALNS GALNS NAPRT NAPRT SCG3 SCG3 FAM49B FAM49B PRTN3 PRTN3 ARG1 ARG1 PYCARD PYCARD DNASE1L1 DNASE1L1 LRG1 LRG1 PSMB1 PSMB1 CTSZ CTSZ XRCC5 XRCC5 VWF VWF GSN GSN PRKCD PRKCD LTF LTF PCYOX1L PCYOX1L ENSSBOP00000026965 ENSSBOP00000026965 TOLLIP TOLLIP KPNB1 KPNB1 S100A12 S100A12 FGA FGA SPARC SPARC PTX3 PTX3 QPCT QPCT PSMA5 PSMA5 FGB FGB PDGFB PDGFB ENSSBOP00000028148 ENSSBOP00000028148 CANT1 CANT1 S100A11 S100A11 CLU CLU CTSA CTSA CTSG CTSG CREG1 CREG1 LCN2 LCN2 ENSSBOP00000029201 ENSSBOP00000029201 TGFB2 TGFB2 S100A9 S100A9 HEBP2 HEBP2 MMP8 MMP8 ARSB ARSB PSMD7 PSMD7 ENSSBOP00000031045 ENSSBOP00000031045 ECM1 ECM1 TGFB3 TGFB3 APAF1 APAF1 RETN RETN ALAD ALAD ENSSBOP00000032006 ENSSBOP00000032006 HRG HRG SPACA7 SPACA7 GCG GCG COTL1 COTL1 CFD CFD SPP2 SPP2 TRAPPC1 TRAPPC1 VEGFC VEGFC MPO MPO STK11IP STK11IP THBS1 THBS1 CLEC3B CLEC3B TCN1 TCN1 FGR FGR GTPBP2 GTPBP2 HK3 HK3 ORM1 ORM1 ENSSBOP00000035298 ENSSBOP00000035298 F13A1 F13A1 IMPDH2 IMPDH2 DBH DBH VEGFB VEGFB CAB39 CAB39 CRISPLD2 CRISPLD2 DNAJC3 DNAJC3 EGF EGF PCSK1 PCSK1 VCP VCP ENSSBOP00000037817 ENSSBOP00000037817 GYG1 GYG1 GLA GLA ENSSBOP00000038352 ENSSBOP00000038352 TOR4A TOR4A GMFB GMFB FAF2 FAF2 BPI BPI SERPINI1 SERPINI1 ENSSBOP00000039813 ENSSBOP00000039813 ENSSBOP00000040310 ENSSBOP00000040310 NEU1 NEU1 PSMD14 PSMD14 C1orf35 C1orf35 PTPN6 PTPN6 PDXK PDXK DPP7 DPP7 SDCBP SDCBP C3 C3 CEP290 CEP290 ATG7 ATG7 FRK FRK SERPINB1 SERPINB1 CRACR2A CRACR2A XRCC6 XRCC6 ENSSBOP00000016822 ENSSBOP00000016822 AMPD3 AMPD3 DYNLT1 DYNLT1 ARSA ARSA ARHGAP9 ARHGAP9 PADI2 PADI2 ACLY ACLY DYNC1H1 DYNC1H1 VTI1B VTI1B HPSE HPSE ERP44 ERP44 ENSSBOP00000018403 ENSSBOP00000018403 VAT1 VAT1 PDGFA PDGFA DOCK2 DOCK2 PPBP PPBP KNG1 KNG1 CRISP3 CRISP3 PRDX4 PRDX4 PSMD3 PSMD3 ITIH4 ITIH4 PENK PENK ACTR1B ACTR1B ELANE ELANE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NHLRC2NHL repeat containing 2. (726 aa)
ENSSBOP00000005101ADF-H domain-containing protein. (171 aa)
VCLVinculin. (1134 aa)
ENSSBOP00000005360Protein S100; Belongs to the S-100 family. (105 aa)
SRGNSerglycin. (160 aa)
ENSSBOP00000005829X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (638 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
SLPISecretory leukocyte peptidase inhibitor. (132 aa)
BIN2Bridging integrator 2. (591 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4355 aa)
F5Coagulation factor V; Belongs to the multicopper oxidase family. (2035 aa)
GIPGastric inhibitory polypeptide. (124 aa)
GNSGlucosamine (N-acetyl)-6-sulfatase. (584 aa)
FABP5FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
TXNDC5Thioredoxin domain containing 5; Belongs to the protein disulfide isomerase family. (324 aa)
PRSS57Serine protease 57; Belongs to the peptidase S1 family. (247 aa)
PA2G4Peptidase_M24 domain-containing protein. (394 aa)
ACTR10Actin related protein 10; Belongs to the actin family. (400 aa)
A1BGAlpha-1-B glycoprotein. (466 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
VPS13AVacuolar protein sorting 13 homolog A. (3174 aa)
ENSSBOP00000009224Uncharacterized protein. (81 aa)
FERMT3Fermitin family member 3. (680 aa)
EPXEosinophil peroxidase. (715 aa)
DSN1DSN1 component of MIS12 kinetochore complex. (354 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (491 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
GMFGGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (142 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (356 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (336 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
OSCAROsteoclast associated Ig-like receptor. (245 aa)
AOC1Amine oxidase. (770 aa)
GGHFolate gamma-glutamyl hydrolase. (281 aa)
COMMD9COMM domain containing 9. (198 aa)
LRRC7Leucine rich repeat containing 7. (1585 aa)
DERADeoxyribose-phosphate aldolase. (323 aa)
IGF2Insulin like growth factor 2. (236 aa)
PRG3Proteoglycan 3, pro eosinophil major basic protein 2. (225 aa)
CHIT1Chitinase 1; Belongs to the glycosyl hydrolase 18 family. (464 aa)
F8Coagulation factor VIII; Belongs to the multicopper oxidase family. (2351 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (479 aa)
GSDMDGasdermin D. (491 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (441 aa)
IMPDHInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (613 aa)
JUPJunction plakoglobin. (745 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
GAS6Growth arrest specific 6. (593 aa)
HEXBBeta-hexosaminidase. (553 aa)
FGGFibrinogen gamma chain. (453 aa)
ENSSBOP00000002902Protein S100; Belongs to the S-100 family. (105 aa)
AGLAmylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase. (1532 aa)
S100ZS100 calcium binding protein Z; Belongs to the S-100 family. (98 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (395 aa)
AZU1Azurocidin 1. (251 aa)
CTSWCathepsin W; Belongs to the peptidase C1 family. (373 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (397 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1256 aa)
OSTF1Osteoclast stimulating factor 1. (214 aa)
TEX264Testis expressed 264, ER-phagy receptor. (313 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
ENSSBOP00000022111Folate_rec domain-containing protein. (124 aa)
SPTAN1Spectrin alpha, non-erythrocytic 1. (2409 aa)
ACAA1Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
S100PS100 calcium binding protein P. (95 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (442 aa)
OLFM4Olfactomedin 4. (502 aa)
ENSSBOP00000022867Ku domain-containing protein. (528 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
DBNLDrebrin like. (445 aa)
GRNGranulin precursor. (592 aa)
GRPGastrin releasing peptide. (147 aa)
PSMB7Proteasome subunit beta. (277 aa)
TIMP2TIMP metallopeptidase inhibitor 2. (176 aa)
RAB27ARAB27A, member RAS oncogene family. (221 aa)
MAPK1Mitogen-activated protein kinase 1. (305 aa)
GALNSGalactosamine (N-acetyl)-6-sulfatase. (509 aa)
NAPRTNicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (521 aa)
SCG3Secretogranin III. (468 aa)
FAM49BFamily with sequence similarity 49 member B. (324 aa)
PRTN3Proteinase 3. (259 aa)
ARG1Arginase. (322 aa)
PYCARDPYD and CARD domain containing. (196 aa)
DNASE1L1Deoxyribonuclease; Belongs to the DNase I family. (302 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (348 aa)
PSMB1Proteasome subunit beta. (241 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (250 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
VWFVon Willebrand factor. (2813 aa)
GSNGelsolin. (767 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (720 aa)
LTFLactotransferrin; Belongs to the transferrin family. (710 aa)
PCYOX1LPrenylcysteine oxidase 1 like. (494 aa)
ENSSBOP00000026965Ku domain-containing protein. (553 aa)
TOLLIPToll interacting protein. (242 aa)
KPNB1Karyopherin subunit beta 1. (929 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa)
FGAFib_alpha domain-containing protein. (280 aa)
SPARCSecreted protein acidic and cysteine rich. (305 aa)
PTX3Pentraxin 3. (381 aa)
QPCTGlutaminyl-peptide cyclotransferase. (361 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
FGBFibrinogen beta chain. (488 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ENSSBOP00000028148Ku domain-containing protein. (545 aa)
CANT1Calcium activated nucleotidase 1. (400 aa)
S100A11EF-hand domain-containing protein. (54 aa)
CLUClusterin. (535 aa)
CTSACarboxypeptidase; Belongs to the peptidase S10 family. (494 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (266 aa)
CREG1Cellular repressor of E1A stimulated genes 1; Belongs to the CREG family. (220 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (240 aa)
ENSSBOP00000029201Uncharacterized protein. (291 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
S100A9S100 calcium binding protein A9; Belongs to the S-100 family. (129 aa)
HEBP2Heme binding protein 2. (198 aa)
MMP8Matrix metallopeptidase 8. (466 aa)
ARSBArylsulfatase B. (458 aa)
PSMD7MPN domain-containing protein. (324 aa)
ENSSBOP00000031045Uncharacterized protein. (282 aa)
ECM1Extracellular matrix protein 1. (546 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
APAF1Apoptotic peptidase activating factor 1. (1193 aa)
RETNResistin. (108 aa)
ALADDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (339 aa)
ENSSBOP00000032006Protein S100; Belongs to the S-100 family. (102 aa)
HRGHistidine rich glycoprotein. (435 aa)
SPACA7Sperm acrosome associated 7. (191 aa)
GCGGlucagon. (180 aa)
COTL1ADF-H domain-containing protein. (150 aa)
CFDComplement factor D; Belongs to the peptidase S1 family. (208 aa)
SPP2Secreted phosphoprotein 2. (205 aa)
TRAPPC1Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (145 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (350 aa)
MPOMyeloperoxidase. (745 aa)
STK11IPSerine/threonine kinase 11 interacting protein. (1047 aa)
THBS1Thrombospondin 1. (1177 aa)
CLEC3BC-type lectin domain family 3 member B. (202 aa)
TCN1Transcobalamin 1. (431 aa)
FGRTyrosine-protein kinase. (529 aa)
GTPBP2GTP binding protein 2. (581 aa)
HK3Hexokinase 3. (923 aa)
ORM1Lipocln_cytosolic_FA-bd_dom domain-containing protein. (210 aa)
ENSSBOP00000035298Proteasome subunit alpha type. (224 aa)
F13A1Coagulation factor XIII A chain. (733 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
DBHDopamine beta-hydroxylase. (621 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (179 aa)
CAB39Calcium binding protein 39. (341 aa)
CRISPLD2Cysteine rich secretory protein LCCL domain containing 2. (497 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1186 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (753 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
ENSSBOP00000037817Proteasome subunit alpha type. (221 aa)
GYG1Glycogenin 1. (410 aa)
GLAAlpha-galactosidase. (429 aa)
ENSSBOP00000038352Peptidase_M24 domain-containing protein. (336 aa)
TOR4ATorsin family 4 member A. (304 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (158 aa)
FAF2Fas associated factor family member 2. (438 aa)
BPIBactericidal permeability increasing protein. (487 aa)
SERPINI1Serpin family I member 1; Belongs to the serpin family. (410 aa)
ENSSBOP00000039813Protein S100; Belongs to the S-100 family. (104 aa)
ENSSBOP00000040310Uncharacterized protein. (120 aa)
NEU1Neuraminidase 1. (414 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
C1orf35Chromosome 1 open reading frame 35. (171 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PDXKPyridoxal kinase. (224 aa)
DPP7Dipeptidyl peptidase 7. (513 aa)
SDCBPSyndecan binding protein. (317 aa)
C3Complement C3. (1628 aa)
CEP290Centrosomal protein 290. (2478 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (733 aa)
FRKTyrosine-protein kinase. (505 aa)
SERPINB1Serpin family B member 1; Belongs to the serpin family. (379 aa)
CRACR2ACalcium release activated channel regulator 2A. (732 aa)
XRCC6SAP domain-containing protein. (361 aa)
ENSSBOP00000016822Ku_C domain-containing protein. (203 aa)
AMPD3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (817 aa)
DYNLT1Uncharacterized protein. (113 aa)
ARSAArylsulfatase A. (509 aa)
ARHGAP9Rho GTPase activating protein 9. (793 aa)
PADI2Peptidyl arginine deiminase 2. (665 aa)
ACLYATP citrate lyase. (1060 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4225 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
HPSEHeparanase. (628 aa)
ERP44Endoplasmic reticulum protein 44. (406 aa)
ENSSBOP00000018403Ku domain-containing protein. (505 aa)
VAT1Vesicle amine transport 1. (258 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (249 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
PPBPC-X-C motif chemokine. (128 aa)
KNG1Kininogen 1. (644 aa)
CRISP3Cysteine rich secretory protein 3; Belongs to the CRISP family. (268 aa)
PRDX4Peroxiredoxin 4. (271 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
ITIH4Inter-alpha-trypsin inhibitor heavy chain 4. (1094 aa)
PENKProenkephalin. (267 aa)
ACTR1BActin related protein 1B. (376 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (265 aa)
Your Current Organism:
Saimiri boliviensis
NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis
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