(25 nodes) Embryonic camera-type eye morphogenesis network (Saimiri boliviensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PAX6	Paired box 6. (488 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	HIPK1	Homeodomain interacting protein kinase 1. (1210 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	ENSSBOP00000009959	Transcription factor SOX. (374 aa)
	TBX2	T-box transcription factor 2. (633 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (275 aa)
	TFAP2A	Transcription factor AP-2 alpha. (557 aa)
	ALDH1A3	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (507 aa)
	KDM2B	Lysine demethylase 2B. (1336 aa)
	TH	Tyrosine hydroxylase. (528 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1196 aa)
	IFT172	Intraflagellar transport 172. (1748 aa)
	PHACTR4	Phosphatase and actin regulator. (713 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	BMP7	Bone morphogenetic protein 7. (430 aa)
	STRA6	Stimulated by retinoic acid 6. (686 aa)
	FOXF2	Forkhead box F2. (406 aa)
	PAX2	Paired box 2. (447 aa)
	FZD5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (556 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1108 aa)
	SIX3	SIX homeobox 3. (329 aa)
	SP3	Sp3 transcription factor. (720 aa)

Your Current Organism:

Saimiri boliviensis

NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A3	STRA6	ENSSBOP00000015871	ENSSBOP00000026390	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family.	Stimulated by retinoic acid 6.	0.402
BMP7	IHH	ENSSBOP00000025908	ENSSBOP00000004043	Bone morphogenetic protein 7.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.633
CITED2	TFAP2A	ENSSBOP00000011194	ENSSBOP00000012156	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	Transcription factor AP-2 alpha.	0.752
FZD5	SIX3	ENSSBOP00000030999	ENSSBOP00000037346	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	SIX homeobox 3.	0.517
FZD5	WNT16	ENSSBOP00000030999	ENSSBOP00000024865	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.840
FZD5	WNT5A	ENSSBOP00000030999	ENSSBOP00000008027	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.983
IHH	BMP7	ENSSBOP00000004043	ENSSBOP00000025908	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 7.	0.633
PAX6	SIX3	ENSSBOP00000001518	ENSSBOP00000037346	Paired box 6.	SIX homeobox 3.	0.720
PAX6	SP3	ENSSBOP00000001518	ENSSBOP00000038535	Paired box 6.	Sp3 transcription factor.	0.456
SIX3	FZD5	ENSSBOP00000037346	ENSSBOP00000030999	SIX homeobox 3.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.517
SIX3	PAX6	ENSSBOP00000037346	ENSSBOP00000001518	SIX homeobox 3.	Paired box 6.	0.720
SP3	PAX6	ENSSBOP00000038535	ENSSBOP00000001518	Sp3 transcription factor.	Paired box 6.	0.456
STRA6	ALDH1A3	ENSSBOP00000026390	ENSSBOP00000015871	Stimulated by retinoic acid 6.	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family.	0.402
TFAP2A	CITED2	ENSSBOP00000012156	ENSSBOP00000011194	Transcription factor AP-2 alpha.	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	0.752
WNT16	FZD5	ENSSBOP00000024865	ENSSBOP00000030999	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.840
WNT16	WNT5A	ENSSBOP00000024865	ENSSBOP00000008027	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.543
WNT5A	FZD5	ENSSBOP00000008027	ENSSBOP00000030999	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.983
WNT5A	WNT16	ENSSBOP00000008027	ENSSBOP00000024865	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.543