(15 nodes) Positive regulation of membrane protein ectodomain proteolysis network (Saimiri boliviensis)

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second shell of interactors

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Predicted Interactions

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Your Input:
	SH3D19	SH3 domain containing 19. (1044 aa)
	ADAM9	ADAM metallopeptidase domain 9. (819 aa)
	SNX33	Sorting nexin. (574 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (462 aa)
	RGMA	Repulsive guidance molecule BMP co-receptor a. (454 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
	ENSSBOP00000003839	Uncharacterized protein. (743 aa)
	APOE	Apolipoprotein E. (261 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	PACSIN3	Protein kinase C and casein kinase substrate in neurons 3. (424 aa)
	ADAM8	ADAM metallopeptidase domain 8. (652 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (877 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
	SNX9	Sorting nexin. (595 aa)

Your Current Organism:

Saimiri boliviensis

NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM9	SNX9	ENSSBOP00000016123	ENSSBOP00000017422	ADAM metallopeptidase domain 9.	Sorting nexin.	0.506
APOE	IFNG	ENSSBOP00000035664	ENSSBOP00000037274	Apolipoprotein E.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.477
APOE	IL1B	ENSSBOP00000035664	ENSSBOP00000027487	Apolipoprotein E.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.504
APOE	TNF	ENSSBOP00000035664	ENSSBOP00000007316	Apolipoprotein E.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.444
ENSSBOP00000003839	SNX9	ENSSBOP00000003839	ENSSBOP00000017422	Uncharacterized protein.	Sorting nexin.	0.506
FURIN	IFNG	ENSSBOP00000018287	ENSSBOP00000037274	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.616
IFNG	APOE	ENSSBOP00000037274	ENSSBOP00000035664	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Apolipoprotein E.	0.477
IFNG	FURIN	ENSSBOP00000037274	ENSSBOP00000018287	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.616
IFNG	IL1B	ENSSBOP00000037274	ENSSBOP00000027487	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.820
IFNG	TNF	ENSSBOP00000037274	ENSSBOP00000007316	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.873
IL1B	APOE	ENSSBOP00000027487	ENSSBOP00000035664	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Apolipoprotein E.	0.504
IL1B	IFNG	ENSSBOP00000027487	ENSSBOP00000037274	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.820
IL1B	TNF	ENSSBOP00000027487	ENSSBOP00000007316	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.834
IL1B	TNFRSF1B	ENSSBOP00000027487	ENSSBOP00000013185	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	TNF receptor superfamily member 1B.	0.575
SNX33	SNX9	ENSSBOP00000013613	ENSSBOP00000017422	Sorting nexin.	Sorting nexin.	0.961
SNX9	ADAM9	ENSSBOP00000017422	ENSSBOP00000016123	Sorting nexin.	ADAM metallopeptidase domain 9.	0.506
SNX9	ENSSBOP00000003839	ENSSBOP00000017422	ENSSBOP00000003839	Sorting nexin.	Uncharacterized protein.	0.506
SNX9	SNX33	ENSSBOP00000017422	ENSSBOP00000013613	Sorting nexin.	Sorting nexin.	0.961
TNF	APOE	ENSSBOP00000007316	ENSSBOP00000035664	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Apolipoprotein E.	0.444
TNF	IFNG	ENSSBOP00000007316	ENSSBOP00000037274	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.873