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DPYD | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (953 aa) | ||||
SERP1 | Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa) | ||||
BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1252 aa) | ||||
CDKAL1 | CDK5 regulatory subunit associated protein 1 like 1. (578 aa) | ||||
CDK5RAP1 | CDK5 regulatory subunit associated protein 1. (587 aa) | ||||
NUBPL | Nucleotide binding protein like. (319 aa) | ||||
PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (505 aa) | ||||
POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2268 aa) | ||||
CIAO3 | Cytosolic iron-sulfur assembly component 3; Belongs to the NARF family. (471 aa) | ||||
IREB2 | Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (967 aa) | ||||
NDUFV1 | Uncharacterized protein. (121 aa) | ||||
ERCC2 | ERCC excision repair 2, TFIIH core complex helicase subunit. (782 aa) | ||||
POLD1 | DNA polymerase. (1088 aa) | ||||
ENSSBOP00000025203 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (764 aa) | ||||
ENSSBOP00000024811 | Uncharacterized protein. (219 aa) | ||||
NDUFS1 | NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (728 aa) | ||||
ABCE1 | ATP binding cassette subfamily E member 1. (599 aa) | ||||
REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3106 aa) | ||||
DNA2 | DNA replication helicase/nuclease 2. (856 aa) | ||||
MUTYH | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (522 aa) | ||||
ACO1 | Aconitase 1; Belongs to the aconitase/IPM isomerase family. (889 aa) | ||||
TYW1 | Flavodoxin-like domain-containing protein. (732 aa) | ||||
ELP3 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (547 aa) | ||||
NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa) | ||||
NDUFS2 | NADH:ubiquinone oxidoreductase core subunit S2; Belongs to the complex I 49 kDa subunit family. (462 aa) | ||||
NFU1 | NFU1 iron-sulfur cluster scaffold. (272 aa) | ||||
RSAD2 | Radical S-adenosyl methionine domain containing 2. (361 aa) | ||||
LIAS | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa) | ||||
SERP2 | Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (65 aa) | ||||
NUBP1 | Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (320 aa) | ||||
SDHB | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (267 aa) | ||||
DPH1 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (401 aa) | ||||
DDX11 | DEAD/H-box helicase 11. (955 aa) | ||||
ENSSBOP00000009671 | Uncharacterized protein. (641 aa) | ||||
MOCS1 | Molybdenum cofactor synthesis 1. (636 aa) | ||||
RSAD1 | Radical S-adenosyl methionine domain containing 1. (372 aa) | ||||
ENSSBOP00000008355 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (517 aa) | ||||
INO80D | INO80 complex subunit D. (1027 aa) | ||||
NDUFS8 | NADH:ubiquinone oxidoreductase core subunit S8. (211 aa) | ||||
CIAPIN1 | Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] (320 aa) | ||||
CIAPIN1-2 | Fe-S cluster assembly protein DRE2. (334 aa) | ||||
ETFDH | Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (618 aa) | ||||
NDUFS7 | NADH:ubiquinone oxidoreductase core subunit S7; Belongs to the complex I 20 kDa subunit family. (240 aa) | ||||
PPAT | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (514 aa) | ||||
RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1306 aa) | ||||
DPH2 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. (489 aa) | ||||
EXO5 | Exonuclease 5. (373 aa) | ||||
NUBP2 | Nucleotide binding protein 2. (252 aa) |