(56 nodes) Endochondral bone morphogenesis network (Saimiri boliviensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	STC1	Stanniocalcin 1. (247 aa)
	COMP	Cartilage oligomeric matrix protein. (740 aa)
	COL1A1	Collagen type I alpha 1 chain. (1464 aa)
	EXT2	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (727 aa)
	ENSSBOP00000002529	Uncharacterized protein. (247 aa)
	CER1	Cerberus 1, DAN family BMP antagonist. (267 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	PHOSPHO2	Phosphatase, orphan 2. (241 aa)
	THBS3	Thrombospondin 3. (956 aa)
	COL27A1	Fibrillar collagen NC1 domain-containing protein. (1855 aa)
	HOXA11	Homeobox A11. (313 aa)
	IMPAD1	Inositol monophosphatase domain containing 1. (359 aa)
	SCX	BHLH domain-containing protein. (170 aa)
	NAB2	NGFI-A binding protein 2. (525 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (655 aa)
	SERPINH1	Serpin family H member 1; Belongs to the serpin family. (418 aa)
	BMPR1B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	NPPC	Natriuretic peptide C. (126 aa)
	ENSSBOP00000017201	GRIP domain-containing protein. (1815 aa)
	DSPP	Uncharacterized protein. (900 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	TRIP11	Thyroid hormone receptor interactor 11. (1980 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (507 aa)
	MATN1	Matrilin 1. (496 aa)
	ANXA6	Annexin. (673 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (479 aa)
	SCUBE2	Signal peptide, CUB domain and EGF like domain containing 2. (957 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	ALPL	Alkaline phosphatase. (524 aa)
	INPPL1	Inositol polyphosphate phosphatase like 1. (1236 aa)
	TSKU	Tsukushi, small leucine rich proteoglycan. (353 aa)
	FGFR3	Fibroblast growth factor receptor. (801 aa)
	NAB1	NGFI-A binding protein 1. (486 aa)
	PEX7	Peroxisomal biogenesis factor 7. (292 aa)
	SOX9	SRY-box transcription factor 9. (452 aa)
	MMP16	Matrix metallopeptidase 16. (607 aa)
	RARB	Retinoic acid receptor beta. (448 aa)
	BMP6	Bone morphogenetic protein 6. (508 aa)
	PHOSPHO1	Phosphoethanolamine/phosphocholine phosphatase. (267 aa)
	DLX5	Distal-less homeobox 5. (289 aa)
	IFT80	Intraflagellar transport 80. (777 aa)
	TRPV4	Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
	COL3A1	Collagen type III alpha 1 chain. (1465 aa)
	RARG	Retinoic acid receptor gamma. (454 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
	MEF2D	Myocyte enhancer factor 2D. (521 aa)
	COL13A1	Collagen type XIII alpha 1 chain. (671 aa)
	RARA	Retinoic acid receptor alpha. (465 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	COL2A1	Collagen type II alpha 1 chain. (1487 aa)
	AXIN2	Axin 2. (842 aa)
	SHOX2	Short stature homeobox 2. (305 aa)
	MMP13	Matrix metallopeptidase 13. (471 aa)

Your Current Organism:

Saimiri boliviensis

NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALPL	COL1A1	ENSSBOP00000021092	ENSSBOP00000001095	Alkaline phosphatase.	Collagen type I alpha 1 chain.	0.509
ALPL	COL2A1	ENSSBOP00000021092	ENSSBOP00000037777	Alkaline phosphatase.	Collagen type II alpha 1 chain.	0.509
ALPL	ENSSBOP00000017201	ENSSBOP00000021092	ENSSBOP00000017201	Alkaline phosphatase.	GRIP domain-containing protein.	0.510
ALPL	PHOSPHO1	ENSSBOP00000021092	ENSSBOP00000030426	Alkaline phosphatase.	Phosphoethanolamine/phosphocholine phosphatase.	0.442
ALPL	SERPINH1	ENSSBOP00000021092	ENSSBOP00000013140	Alkaline phosphatase.	Serpin family H member 1; Belongs to the serpin family.	0.509
ALPL	TRIP11	ENSSBOP00000021092	ENSSBOP00000017609	Alkaline phosphatase.	Thyroid hormone receptor interactor 11.	0.510
AXIN2	FGF18	ENSSBOP00000037936	ENSSBOP00000015578	Axin 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.620
AXIN2	IHH	ENSSBOP00000037936	ENSSBOP00000004043	Axin 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.616
BMP4	BMP6	ENSSBOP00000004048	ENSSBOP00000029668	Bone morphogenetic protein 4.	Bone morphogenetic protein 6.	0.960
BMP4	BMPR1B	ENSSBOP00000004048	ENSSBOP00000014759	Bone morphogenetic protein 4.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.992
BMP4	BMPR2	ENSSBOP00000004048	ENSSBOP00000017440	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.987
BMP4	CER1	ENSSBOP00000004048	ENSSBOP00000003118	Bone morphogenetic protein 4.	Cerberus 1, DAN family BMP antagonist.	0.530
BMP4	DLX5	ENSSBOP00000004048	ENSSBOP00000031824	Bone morphogenetic protein 4.	Distal-less homeobox 5.	0.517
BMP4	FGF18	ENSSBOP00000004048	ENSSBOP00000015578	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
BMP4	TGFBR2	ENSSBOP00000004048	ENSSBOP00000034745	Bone morphogenetic protein 4.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.483
BMP6	BMP4	ENSSBOP00000029668	ENSSBOP00000004048	Bone morphogenetic protein 6.	Bone morphogenetic protein 4.	0.960
BMP6	BMPR1B	ENSSBOP00000029668	ENSSBOP00000014759	Bone morphogenetic protein 6.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.971
BMP6	BMPR2	ENSSBOP00000029668	ENSSBOP00000017440	Bone morphogenetic protein 6.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.967
BMP6	TGFBR2	ENSSBOP00000029668	ENSSBOP00000034745	Bone morphogenetic protein 6.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.420
BMPR1B	BMP4	ENSSBOP00000014759	ENSSBOP00000004048	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.992