(70 nodes) Regulation of cholesterol biosynthesis by SREBP (SREBF) network (Saimiri boliviensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHD9	Chromodomain helicase DNA binding protein 9. (2897 aa)
	LSS	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (728 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1543 aa)
	RXRA	Retinoid X receptor alpha. (479 aa)
	ENSSBOP00000036337	Uncharacterized protein. (177 aa)
	MVK	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa)
	ENSSBOP00000036628	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (205 aa)
	SQLE	Squalene epoxidase. (582 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
	CYP51A1	Uncharacterized protein; Belongs to the cytochrome P450 family. (507 aa)
	ENSSBOP00000039205	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (328 aa)
	NCOA6	Nuclear receptor coactivator 6. (2067 aa)
	NFYA	Nuclear transcription factor Y subunit alpha. (347 aa)
	SAR1A	Secretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
	MBTPS1	Membrane bound transcription factor peptidase, site 1. (1053 aa)
	KPNB1	Karyopherin subunit beta 1. (929 aa)
	DHCR7	7-dehydrocholesterol reductase. (475 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (514 aa)
	SEC24C	Uncharacterized protein. (1118 aa)
	SEC23A	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1119 aa)
	SCD	Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
	NCOA2	Nuclear receptor coactivator. (1464 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1274 aa)
	CARM1	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (542 aa)
	GGPS1	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (300 aa)
	NCOA1	Nuclear receptor coactivator. (1441 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2377 aa)
	ENSSBOP00000028633	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (396 aa)
	ENSSBOP00000028326	Uncharacterized protein. (218 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2370 aa)
	ELOVL6	Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa)
	ENSSBOP00000000715	Uncharacterized protein. (99 aa)
	ENSSBOP00000001932	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (366 aa)
	TBL1X	Transducin beta like 1 X-linked. (568 aa)
	FDPS	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (419 aa)
	SC5D	Sterol-C5-desaturase; Belongs to the sterol desaturase family. (299 aa)
	ENSSBOP00000007572	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (395 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
	SEC23B	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (767 aa)
	TM7SF2	Transmembrane 7 superfamily member 2. (482 aa)
	SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
	IDI1	Isopentenyl-diphosphate delta isomerase 1. (253 aa)
	SP1	Sp1 transcription factor. (726 aa)
	NFYB	Nuclear transcription factor Y subunit beta. (207 aa)
	SAR1B	Secretion associated Ras related GTPase 1B. (167 aa)
	NFYC	Nuclear transcription factor Y subunit gamma. (439 aa)
	RAN	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (233 aa)
	TGS1	Trimethylguanosine synthase 1. (817 aa)
	MVD	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (400 aa)
	ENSSBOP00000016360	Uncharacterized protein. (67 aa)
	SEC24A	SEC24 homolog A, COPII coat complex component. (1077 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (151 aa)
	ENSSBOP00000018465	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (358 aa)
	SEC24D	SEC24 homolog D, COPII coat complex component. (1033 aa)
	MBTPS2	Membrane bound transcription factor peptidase, site 2. (507 aa)
	PMVK	Phosphomevalonate kinase. (192 aa)
	FASN	Fatty acid synthase. (2526 aa)
	ENSSBOP00000024214	Nudix hydrolase domain-containing protein. (195 aa)
	ENSSBOP00000023843	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (336 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
	SCAP	SREBF chaperone. (1278 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
	CREBBP	CREB binding protein. (2439 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (1230 aa)
	FDFT1	Farnesyl-diphosphate farnesyltransferase 1. (417 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	ADGRD1	Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family. (906 aa)
	HELZ2	Helicase with zinc finger 2. (2651 aa)
	ENSSBOP00000034325	Uncharacterized protein; Belongs to the cytochrome P450 family. (174 aa)

Your Current Organism:

Saimiri boliviensis

NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACACB	ENSSBOP00000000178	ENSSBOP00000029228	Acetyl-CoA carboxylase alpha.	Acetyl-CoA carboxylase beta.	0.921
ACACA	ELOVL6	ENSSBOP00000000178	ENSSBOP00000000596	Acetyl-CoA carboxylase alpha.	Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...]	0.580
ACACA	FASN	ENSSBOP00000000178	ENSSBOP00000024531	Acetyl-CoA carboxylase alpha.	Fatty acid synthase.	0.971
ACACA	HMGCR	ENSSBOP00000000178	ENSSBOP00000023577	Acetyl-CoA carboxylase alpha.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.465
ACACA	SCD	ENSSBOP00000000178	ENSSBOP00000033316	Acetyl-CoA carboxylase alpha.	Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family.	0.634
ACACA	SREBF1	ENSSBOP00000000178	ENSSBOP00000026830	Acetyl-CoA carboxylase alpha.	Sterol regulatory element binding transcription factor 1.	0.681
ACACA	SREBF2	ENSSBOP00000000178	ENSSBOP00000033655	Acetyl-CoA carboxylase alpha.	Sterol regulatory element binding transcription factor 2.	0.408
ACACB	ACACA	ENSSBOP00000029228	ENSSBOP00000000178	Acetyl-CoA carboxylase beta.	Acetyl-CoA carboxylase alpha.	0.921
ACACB	ELOVL6	ENSSBOP00000029228	ENSSBOP00000000596	Acetyl-CoA carboxylase beta.	Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...]	0.482
ACACB	FASN	ENSSBOP00000029228	ENSSBOP00000024531	Acetyl-CoA carboxylase beta.	Fatty acid synthase.	0.967
ACACB	HMGCR	ENSSBOP00000029228	ENSSBOP00000023577	Acetyl-CoA carboxylase beta.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.465
ACACB	SCD	ENSSBOP00000029228	ENSSBOP00000033316	Acetyl-CoA carboxylase beta.	Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family.	0.534
ACACB	SREBF1	ENSSBOP00000029228	ENSSBOP00000026830	Acetyl-CoA carboxylase beta.	Sterol regulatory element binding transcription factor 1.	0.547
ACACB	SREBF2	ENSSBOP00000029228	ENSSBOP00000033655	Acetyl-CoA carboxylase beta.	Sterol regulatory element binding transcription factor 2.	0.403
ADGRD1	KPNB1	ENSSBOP00000033857	ENSSBOP00000027379	Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.	Karyopherin subunit beta 1.	0.920
CARM1	CREBBP	ENSSBOP00000031201	ENSSBOP00000022192	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	CREB binding protein.	0.888
CARM1	FDFT1	ENSSBOP00000031201	ENSSBOP00000019399	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Farnesyl-diphosphate farnesyltransferase 1.	0.402
CARM1	HELZ2	ENSSBOP00000031201	ENSSBOP00000034324	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Helicase with zinc finger 2.	0.842
CARM1	MED1	ENSSBOP00000031201	ENSSBOP00000034770	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.942
CARM1	NCOA1	ENSSBOP00000031201	ENSSBOP00000029337	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator.	0.818