(59 nodes) NOTCH1 Intracellular Domain Regulates Transcription network (Saimiri boliviensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	SKP1	Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
	TBL1X	Transducin beta like 1 X-linked. (568 aa)
	ENSSBOP00000003537	Ubiquitin-like domain-containing protein. (155 aa)
	ENSSBOP00000005716	Uncharacterized protein; Belongs to the SKP1 family. (137 aa)
	ENSSBOP00000006203	Ubiquitin-like domain-containing protein. (156 aa)
	ENSSBOP00000006391	Uncharacterized protein. (1054 aa)
	ENSSBOP00000008867	Uncharacterized protein; Belongs to the cyclin family. (270 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (910 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	HDAC9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
	RBX1	Ring-box 1. (105 aa)
	HDAC6	Histone deacetylase 6. (1244 aa)
	CCNC	Uncharacterized protein; Belongs to the cyclin family. (283 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
	NCOR1	Nuclear receptor corepressor 1. (2438 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (530 aa)
	HDAC10	Histone deacetylase 10. (693 aa)
	TLE1	TLE family member 1, transcriptional corepressor. (779 aa)
	NBEA	Neurobeachin. (2917 aa)
	MAML3	Mastermind like transcriptional coactivator 3. (1128 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	ENSSBOP00000039148	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (392 aa)
	HEYL	Hes related family bHLH transcription factor with YRPW motif like. (328 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	ENSSBOP00000037087	Hist_deacetyl domain-containing protein. (226 aa)
	ENSSBOP00000036436	SKIP_SNW domain-containing protein. (563 aa)
	ENSSBOP00000035130	Ubiquitin-like domain-containing protein. (135 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
	TLE3	TLE family member 3, transcriptional corepressor. (784 aa)
	TLE4	TLE family member 4, transcriptional corepressor. (790 aa)
	LRBA	LPS responsive beige-like anchor protein. (2854 aa)
	CDK8	Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
	MAML2	Mastermind like transcriptional coactivator 2. (1139 aa)
	ENSSBOP00000029848	Uncharacterized protein. (141 aa)
	HDAC11	Histone deacetylase 11. (347 aa)
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1000 aa)
	TLE2	TLE family member 2, transcriptional corepressor. (738 aa)
	ENSSBOP00000025824	Uncharacterized protein; Belongs to the SKP1 family. (158 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (826 aa)
	KAT2B	Lysine acetyltransferase 2B. (675 aa)
	FBXW7	F-box and WD repeat domain containing 7. (706 aa)
	MAMLD1	Mastermind like domain containing 1. (842 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	CREBBP	CREB binding protein. (2439 aa)
	ENSSBOP00000021549	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
	EP300	E1A binding protein p300. (2420 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1090 aa)
	ENSSBOP00000021340	Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
	NCOR2	Nuclear receptor corepressor 2. (2508 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1088 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (514 aa)
	ENSSBOP00000019452	Ubiquitin-like domain-containing protein. (135 aa)
	HDAC2	Hist_deacetyl domain-containing protein. (314 aa)
	HDAC8	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (415 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	SNW1	SKIP_SNW domain-containing protein. (571 aa)
	NOTCH1	Notch receptor 1. (2538 aa)

Your Current Organism:

Saimiri boliviensis

NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNC	CDK8	ENSSBOP00000014196	ENSSBOP00000031089	Uncharacterized protein; Belongs to the cyclin family.	Cyclin dependent kinase 8; Belongs to the protein kinase superfamily.	0.979
CDK8	CCNC	ENSSBOP00000031089	ENSSBOP00000014196	Cyclin dependent kinase 8; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the cyclin family.	0.979
CDK8	ENSSBOP00000008867	ENSSBOP00000031089	ENSSBOP00000008867	Cyclin dependent kinase 8; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the cyclin family.	0.979
CREBBP	ENSSBOP00000006391	ENSSBOP00000022192	ENSSBOP00000006391	CREB binding protein.	Uncharacterized protein.	0.504
CREBBP	ENSSBOP00000021549	ENSSBOP00000022192	ENSSBOP00000021549	CREB binding protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.639
CREBBP	ENSSBOP00000029848	ENSSBOP00000022192	ENSSBOP00000029848	CREB binding protein.	Uncharacterized protein.	0.504
CREBBP	ENSSBOP00000036436	ENSSBOP00000022192	ENSSBOP00000036436	CREB binding protein.	SKIP_SNW domain-containing protein.	0.627
CREBBP	ENSSBOP00000037087	ENSSBOP00000022192	ENSSBOP00000037087	CREB binding protein.	Hist_deacetyl domain-containing protein.	0.620
CREBBP	ENSSBOP00000039148	ENSSBOP00000022192	ENSSBOP00000039148	CREB binding protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.639
CREBBP	EP300	ENSSBOP00000022192	ENSSBOP00000021524	CREB binding protein.	E1A binding protein p300.	0.998
CREBBP	HDAC1	ENSSBOP00000022192	ENSSBOP00000018138	CREB binding protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.639
CREBBP	HDAC10	ENSSBOP00000022192	ENSSBOP00000015792	CREB binding protein.	Histone deacetylase 10.	0.434
CREBBP	HDAC11	ENSSBOP00000022192	ENSSBOP00000027702	CREB binding protein.	Histone deacetylase 11.	0.467
CREBBP	HDAC2	ENSSBOP00000022192	ENSSBOP00000019047	CREB binding protein.	Hist_deacetyl domain-containing protein.	0.620
CREBBP	HDAC3	ENSSBOP00000022192	ENSSBOP00000015842	CREB binding protein.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.753
CREBBP	HDAC4	ENSSBOP00000022192	ENSSBOP00000021361	CREB binding protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.507
CREBBP	HDAC5	ENSSBOP00000022192	ENSSBOP00000019829	CREB binding protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.636
CREBBP	HDAC6	ENSSBOP00000022192	ENSSBOP00000014011	CREB binding protein.	Histone deacetylase 6.	0.504
CREBBP	HDAC7	ENSSBOP00000022192	ENSSBOP00000026861	CREB binding protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.554
CREBBP	HDAC8	ENSSBOP00000022192	ENSSBOP00000018647	CREB binding protein.	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.551