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ARHGEF28 ARHGEF28 ENSSBOP00000026665 ENSSBOP00000026665 APH1B APH1B GIT1 GIT1 MYL6 MYL6 FMN2 FMN2 NGEF NGEF ENSSBOP00000028535 ENSSBOP00000028535 EFNB2 EFNB2 CLTCL1 CLTCL1 MYH9 MYH9 EFNA3 EFNA3 FYN FYN EPHA7 EPHA7 MMP2 MMP2 EPHA4 EPHA4 ARPC2 ARPC2 ENSSBOP00000032178 ENSSBOP00000032178 AP2S1 AP2S1 ADAM10 ADAM10 FMN1 FMN1 EPHB6 EPHB6 EPHB4 EPHB4 ENSSBOP00000034105 ENSSBOP00000034105 DSTN DSTN EPHB3 EPHB3 PAK2 PAK2 ACTB ACTB AP2B1 AP2B1 ENSSBOP00000036310 ENSSBOP00000036310 NCSTN NCSTN ROCK1 ROCK1 ENSSBOP00000037313 ENSSBOP00000037313 YES1 YES1 ENSSBOP00000037509 ENSSBOP00000037509 CLTC CLTC GRIN1 GRIN1 EFNA5 EFNA5 GRIN2B GRIN2B EPHA3 EPHA3 PAK1 PAK1 EFNA1 EFNA1 WASL WASL MYL9 MYL9 AP2A2 AP2A2 VAV3 VAV3 MYH10 MYH10 ENSSBOP00000040512 ENSSBOP00000040512 ENSSBOP00000026787 ENSSBOP00000026787 ENSSBOP00000025905 ENSSBOP00000025905 MYH11 MYH11 CFL1 CFL1 ARPC5L ARPC5L ROCK2 ROCK2 ITSN1 ITSN1 FNDC3A FNDC3A CLTB CLTB EPHA2 EPHA2 ELSPBP1 ELSPBP1 EFNA4 EFNA4 PSEN2 PSEN2 KALRN KALRN SDC2 SDC2 EPHA6 EPHA6 EFNB3 EFNB3 ACTR2 ACTR2 ENSSBOP00000022925 ENSSBOP00000022925 MYH14 MYH14 ENSSBOP00000022800 ENSSBOP00000022800 LYN LYN ARPC5 ARPC5 ENSSBOP00000001180 ENSSBOP00000001180 AP2M1 AP2M1 CFL2 CFL2 ENSSBOP00000002754 ENSSBOP00000002754 ARHGEF7 ARHGEF7 ENSSBOP00000003434 ENSSBOP00000003434 ENSSBOP00000003528 ENSSBOP00000003528 ARPC1B ARPC1B ENSSBOP00000004217 ENSSBOP00000004217 ENSSBOP00000004420 ENSSBOP00000004420 DNM1 DNM1 ENSSBOP00000005039 ENSSBOP00000005039 ARPC3 ARPC3 ARPC4 ARPC4 ACTL7A ACTL7A ENSSBOP00000006339 ENSSBOP00000006339 SDCBP2 SDCBP2 EFNB1 EFNB1 ENSSBOP00000008122 ENSSBOP00000008122 ACTR3B ACTR3B EPHB2 EPHB2 CLTA CLTA PTK2 PTK2 ENSSBOP00000009356 ENSSBOP00000009356 EPHB1 EPHB1 MMP9 MMP9 PAK3 PAK3 ENSSBOP00000009971 ENSSBOP00000009971 NCK2 NCK2 EFNA2 EFNA2 ENSSBOP00000010668 ENSSBOP00000010668 PSENEN PSENEN AP2A1 AP2A1 EPHA8 EPHA8 ACTL8 ACTL8 EPHA5 EPHA5 HRAS HRAS TIAM1 TIAM1 PSEN1 PSEN1 SDCBP SDCBP FNDC3B FNDC3B RASA1 RASA1 VAV2 VAV2 ENSSBOP00000015713 ENSSBOP00000015713 ACTR3 ACTR3 LIMK2 LIMK2 APH1A APH1A LIMK1 LIMK1 EPHA10 EPHA10 CDC42 CDC42 EPHA1 EPHA1 SRC SRC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARHGEF28Rho guanine nucleotide exchange factor 28. (1715 aa)
ENSSBOP00000026665ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (206 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
GIT1GIT ArfGAP 1. (766 aa)
MYL6Uncharacterized protein. (223 aa)
FMN2FH2 domain-containing protein. (190 aa)
NGEFNeuronal guanine nucleotide exchange factor. (707 aa)
ENSSBOP00000028535Uncharacterized protein; Belongs to the actin family. (309 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (336 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1642 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1964 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (232 aa)
FYNTyrosine-protein kinase. (537 aa)
EPHA7EPH receptor A7. (998 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
EPHA4EPH receptor A4. (949 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
ENSSBOP00000032178Uncharacterized protein. (185 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (157 aa)
ADAM10ADAM metallopeptidase domain 10. (751 aa)
FMN1Formin 1. (1422 aa)
EPHB6EPH receptor B6. (1022 aa)
EPHB4EPH receptor B4. (987 aa)
ENSSBOP00000034105AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (458 aa)
DSTNADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (165 aa)
EPHB3EPH receptor B3. (989 aa)
PAK2Non-specific serine/threonine protein kinase. (525 aa)
ACTBActin beta. (378 aa)
AP2B1AP complex subunit beta. (951 aa)
ENSSBOP00000036310annotation not available (334 aa)
NCSTNNicastrin. (716 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
ENSSBOP00000037313Uncharacterized protein; Belongs to the actin family. (360 aa)
YES1Tyrosine-protein kinase. (548 aa)
ENSSBOP00000037509annotation not available (164 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (864 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1483 aa)
EPHA3EPH receptor A3. (954 aa)
PAK1Non-specific serine/threonine protein kinase. (555 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
WASLWASP like actin nucleation promoting factor. (507 aa)
MYL9Myosin light chain 9. (172 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (969 aa)
VAV3Vav guanine nucleotide exchange factor 3. (844 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
ENSSBOP00000040512Uncharacterized protein. (158 aa)
ENSSBOP00000026787Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (163 aa)
ENSSBOP00000025905Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (102 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1996 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (175 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1386 aa)
ITSN1Intersectin 1. (1690 aa)
FNDC3AFibronectin type III domain containing 3A. (1206 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (181 aa)
EPHA2EPH receptor A2. (965 aa)
ELSPBP1Epididymal sperm binding protein 1. (223 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (201 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (546 aa)
KALRNKalirin RhoGEF kinase. (2985 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
EPHA6EPH receptor A6. (1018 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (402 aa)
ENSSBOP00000022925Uncharacterized protein. (378 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1923 aa)
ENSSBOP00000022800ADF-H domain-containing protein. (207 aa)
LYNTyrosine-protein kinase. (512 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ENSSBOP00000001180ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (165 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ENSSBOP00000002754Uncharacterized protein. (147 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (780 aa)
ENSSBOP00000003434Uncharacterized protein. (147 aa)
ENSSBOP00000003528Uncharacterized protein. (1061 aa)
ARPC1BActin related protein 2/3 complex subunit 1B. (425 aa)
ENSSBOP00000004217Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (163 aa)
ENSSBOP00000004420Uncharacterized protein. (151 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (810 aa)
ENSSBOP00000005039Uncharacterized protein. (178 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (170 aa)
ARPC4Actin related protein 2/3 complex subunit 4. (227 aa)
ACTL7AActin like 7A; Belongs to the actin family. (434 aa)
ENSSBOP00000006339Uncharacterized protein. (169 aa)
SDCBP2Syndecan binding protein 2. (292 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
ENSSBOP00000008122Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (291 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (415 aa)
EPHB2EPH receptor B2. (1088 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (979 aa)
ENSSBOP00000009356ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (157 aa)
EPHB1EPH receptor B1. (984 aa)
MMP9Matrix metallopeptidase 9. (703 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
ENSSBOP00000009971Uncharacterized protein; Belongs to the actin family. (343 aa)
NCK2Cytoplasmic protein. (380 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (197 aa)
ENSSBOP00000010668Uncharacterized protein. (129 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (967 aa)
EPHA8EPH receptor A8. (1019 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
EPHA5EPH receptor A5. (1038 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
SDCBPSyndecan binding protein. (317 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
RASA1RAS p21 protein activator 1. (1049 aa)
VAV2Vav guanine nucleotide exchange factor 2. (810 aa)
ENSSBOP00000015713EF-hand domain-containing protein. (86 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (413 aa)
LIMK2LIM domain kinase 2. (638 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
LIMK1LIM domain kinase 1. (591 aa)
EPHA10EPH receptor A10. (902 aa)
CDC42Uncharacterized protein. (191 aa)
EPHA1EPH receptor A1. (972 aa)
SRCTyrosine-protein kinase. (542 aa)
Your Current Organism:
Saimiri boliviensis
NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis
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