(25 nodes) TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain network (Saimiri boliviensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BCL6	BCL6 transcription repressor. (706 aa)
	TP53I3	Tumor protein p53 inducible protein 3. (332 aa)
	ZADH2	Zinc binding alcohol dehydrogenase domain containing 2. (363 aa)
	ENSSBOP00000038594	Uncharacterized protein. (96 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	RABGGTB	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. (331 aa)
	PPP1R13B	Protein phosphatase 1 regulatory subunit 13B. (1158 aa)
	ENSSBOP00000025679	PKS_ER domain-containing protein. (336 aa)
	CHM	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (656 aa)
	RTN4IP1	Reticulon 4 interacting protein 1. (396 aa)
	CRYZ	PKS_ER domain-containing protein. (329 aa)
	NDRG1	N-myc downstream regulated 1. (394 aa)
	BIRC5	Baculoviral IAP repeat containing 5. (150 aa)
	ENSSBOP00000019797	Uncharacterized protein. (359 aa)
	BCL6B	BCL6B transcription repressor. (504 aa)
	NDRG3	Uncharacterized protein. (388 aa)
	RABGGTA	Rab geranylgeranyltransferase subunit alpha. (567 aa)
	PERP	P53 apoptosis effector related to PMP22. (189 aa)
	PTAR1	Protein prenyltransferase alpha subunit repeat containing 1. (422 aa)
	BCL2L14	BCL2 like 14. (355 aa)
	CRYZL1	Crystallin zeta like 1. (349 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (635 aa)
	VAT1L	Vesicle amine transport 1 like. (419 aa)
	NDRG4	NDRG family member 4. (421 aa)
	NDRG2	NDRG family member 2. (371 aa)

Your Current Organism:

Saimiri boliviensis

NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	BCL6B	ENSSBOP00000019458	ENSSBOP00000018028	BCL6 transcription repressor.	BCL6B transcription repressor.	0.620
BCL6B	BCL6	ENSSBOP00000018028	ENSSBOP00000019458	BCL6B transcription repressor.	BCL6 transcription repressor.	0.620
CHM	PTAR1	ENSSBOP00000022801	ENSSBOP00000013001	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Protein prenyltransferase alpha subunit repeat containing 1.	0.937
CHM	RABGGTA	ENSSBOP00000022801	ENSSBOP00000016545	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Rab geranylgeranyltransferase subunit alpha.	0.985
CHM	RABGGTB	ENSSBOP00000022801	ENSSBOP00000028117	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX.	0.959
CRYZL1	ZADH2	ENSSBOP00000011001	ENSSBOP00000038994	Crystallin zeta like 1.	Zinc binding alcohol dehydrogenase domain containing 2.	0.562
ENSSBOP00000025679	TP53I3	ENSSBOP00000025679	ENSSBOP00000040124	PKS_ER domain-containing protein.	Tumor protein p53 inducible protein 3.	0.901
NDRG1	NDRG2	ENSSBOP00000021571	ENSSBOP00000004201	N-myc downstream regulated 1.	NDRG family member 2.	0.512
NDRG1	TP63	ENSSBOP00000021571	ENSSBOP00000034352	N-myc downstream regulated 1.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.407
NDRG2	NDRG1	ENSSBOP00000004201	ENSSBOP00000021571	NDRG family member 2.	N-myc downstream regulated 1.	0.512
PERP	TP63	ENSSBOP00000015263	ENSSBOP00000034352	P53 apoptosis effector related to PMP22.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.556
PPP1R13B	TP63	ENSSBOP00000027849	ENSSBOP00000034352	Protein phosphatase 1 regulatory subunit 13B.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.695
PPP1R13B	TP73	ENSSBOP00000027849	ENSSBOP00000010588	Protein phosphatase 1 regulatory subunit 13B.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.712
PTAR1	CHM	ENSSBOP00000013001	ENSSBOP00000022801	Protein prenyltransferase alpha subunit repeat containing 1.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.937
PTAR1	RABGGTB	ENSSBOP00000013001	ENSSBOP00000028117	Protein prenyltransferase alpha subunit repeat containing 1.	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX.	0.979
RABGGTA	CHM	ENSSBOP00000016545	ENSSBOP00000022801	Rab geranylgeranyltransferase subunit alpha.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.985
RABGGTA	RABGGTB	ENSSBOP00000016545	ENSSBOP00000028117	Rab geranylgeranyltransferase subunit alpha.	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX.	0.998
RABGGTB	CHM	ENSSBOP00000028117	ENSSBOP00000022801	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.959
RABGGTB	PTAR1	ENSSBOP00000028117	ENSSBOP00000013001	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX.	Protein prenyltransferase alpha subunit repeat containing 1.	0.979
RABGGTB	RABGGTA	ENSSBOP00000028117	ENSSBOP00000016545	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX.	Rab geranylgeranyltransferase subunit alpha.	0.998