(117 nodes) RAB GEFs exchange GTP for GDP on RABs network (Saimiri boliviensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	RAB35	RAB35, member RAS oncogene family. (212 aa)
	WDR54	WD repeat domain 54. (341 aa)
	RAB7A	RAB7A, member RAS oncogene family. (217 aa)
	ENSSBOP00000002710	Uncharacterized protein. (981 aa)
	TRAPPC3L	Trafficking protein particle complex subunit; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (148 aa)
	ANKRD27	Ankyrin repeat domain 27. (1035 aa)
	DENND2D	DENN domain containing 2D. (470 aa)
	RSPH1	Radial spoke head component 1. (344 aa)
	TRAPPC13	Trafficking protein particle complex 13. (418 aa)
	ALS2CL	ALS2 C-terminal like. (953 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
	MON1B	MON1 homolog B, secretory trafficking associated. (547 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	RAB5B	RAB5B, member RAS oncogene family. (190 aa)
	SBF1	SET binding factor 1. (1899 aa)
	ENSSBOP00000038478	Uncharacterized protein. (249 aa)
	RIN1	Ras and Rab interactor 1. (783 aa)
	RIN3	Ras and Rab interactor 3. (982 aa)
	RAB10	RAB10, member RAS oncogene family. (200 aa)
	DENND6A	DENN domain containing 6A. (608 aa)
	RAB38	RAB38, member RAS oncogene family. (211 aa)
	ULK2	Unc-51 like autophagy activating kinase 2. (925 aa)
	RSPH10B	Uncharacterized protein. (821 aa)
	HPS4	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (706 aa)
	RAB21	RAB21, member RAS oncogene family. (225 aa)
	TRAPPC2	Trafficking protein particle complex 2. (172 aa)
	RAB3IL1	RAB3A interacting protein like 1. (434 aa)
	DENND1C	DENN domain containing 1C. (880 aa)
	ENSSBOP00000028045	Uncharacterized protein. (118 aa)
	DENND2C	DENN domain containing 2C. (928 aa)
	TRAPPC6A	Trafficking protein particle complex 6A. (159 aa)
	RINL	Ras and Rab interactor like. (565 aa)
	TRAPPC1	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (145 aa)
	RGP1	RGP1 homolog, RAB6A GEF complex partner 1. (402 aa)
	SBF2	SET binding factor 2. (1783 aa)
	RAB32	RAB32, member RAS oncogene family. (216 aa)
	MON1A	MON1 homolog A, secretory trafficking associated. (674 aa)
	RAB5C	Uncharacterized protein. (216 aa)
	RAB27B	RAB27B, member RAS oncogene family. (218 aa)
	CCZ1	Uncharacterized protein. (464 aa)
	ENSSBOP00000032229	Uncharacterized protein. (133 aa)
	TRAPPC11	Trafficking protein particle complex 11. (1133 aa)
	HPS1	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (700 aa)
	DENND2B	Suppression of tumorigenicity 5. (1137 aa)
	JPH1	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (661 aa)
	RAB14	RAB14, member RAS oncogene family. (215 aa)
	DENND2A	DENN domain containing 2A. (907 aa)
	GAPVD1	GTPase activating protein and VPS9 domains 1. (1487 aa)
	CHM	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (656 aa)
	RAB27A	RAB27A, member RAS oncogene family. (221 aa)
	RAB6A	RAB6A, member RAS oncogene family. (176 aa)
	RAB3IP	RAB3A interacting protein. (460 aa)
	DENND4B	DENN domain containing 4B. (1499 aa)
	DENND1B	DENN domain containing 1B. (768 aa)
	RIN2	Ras and Rab interactor 2. (929 aa)
	RAB5A	RAB5A, member RAS oncogene family. (174 aa)
	ENSSBOP00000025163	Uncharacterized protein. (58 aa)
	DENND6B	DENN domain containing 6B. (566 aa)
	ULK1	Unc-51 like autophagy activating kinase 1. (1006 aa)
	MORN5	MORN repeat containing 5. (172 aa)
	RAB3GAP2	RAB3 GTPase activating non-catalytic protein subunit 2. (1376 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	RAB8B	RAB8B, member RAS oncogene family. (207 aa)
	DENND1A	DENN domain containing 1A. (1075 aa)
	RAB1B	RAB1B, member RAS oncogene family. (201 aa)
	TRAPPC9	Trafficking protein particle complex 9. (1148 aa)
	TRAPPC2L	Trafficking protein particle complex 2 like. (131 aa)
	MORN4	MORN repeat containing 4. (146 aa)
	TRAPPC3	Trafficking protein particle complex subunit; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (185 aa)
	RAB3GAP1	Uncharacterized protein. (849 aa)
	TRAPPC6B	Trafficking protein particle complex 6B. (158 aa)
	DENND4C	DENN domain containing 4C. (1958 aa)
	JPH4	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (628 aa)
	GRIPAP1	GRIP1 associated protein 1. (823 aa)
	ENSSBOP00000040670	Uncharacterized protein. (140 aa)
	MORN1	MORN repeat containing 1. (472 aa)
	SH3YL1	SH3 and SYLF domain containing 1. (347 aa)
	ENSSBOP00000020002	Uncharacterized protein. (88 aa)
	ENSSBOP00000019357	Uncharacterized protein. (127 aa)
	ALS2	Alsin Rho guanine nucleotide exchange factor ALS2. (1610 aa)
	GDI2	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (445 aa)
	MORN3	MORN repeat containing 3. (241 aa)
	ENSSBOP00000018573	Uncharacterized protein. (78 aa)
	ANKMY1	Ankyrin repeat and MYND domain containing 1. (985 aa)
	DENND5B	DENN domain containing 5B. (1225 aa)
	RAB6B	RAB6B, member RAS oncogene family. (208 aa)
	ENSSBOP00000017357	Uncharacterized protein. (137 aa)
	ENSSBOP00000017316	Uncharacterized protein. (167 aa)
	RAB39B	RAB39B, member RAS oncogene family. (213 aa)
	ENSSBOP00000016821	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (169 aa)
	RAB31	RAB31, member RAS oncogene family. (194 aa)
	RABGEF1	Uncharacterized protein. (491 aa)
	RAB8A	RAB8A, member RAS oncogene family. (207 aa)
	RAB18	RAB18, member RAS oncogene family. (235 aa)
	RAB1A	Uncharacterized protein. (205 aa)
	RIC1	RIC1 homolog, RAB6A GEF complex partner 1. (1422 aa)
	TRAPPC8	Trafficking protein particle complex 8. (1390 aa)
	RAB3A	RAB3A, member RAS oncogene family. (220 aa)
	MADD	MAP kinase activating death domain. (1654 aa)
	TRAPPC12	TPR_REGION domain-containing protein. (379 aa)
	JPH3	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (748 aa)
	DENND4A	DENN domain containing 4A. (1892 aa)
	GDI1	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (477 aa)
	RAB12	RAB12, member RAS oncogene family. (262 aa)
	GAREM1	GRB2 associated regulator of MAPK1 subtype 1. (869 aa)
	VPS9D1	VPS9 domain containing 1. (569 aa)
	RAB13	Uncharacterized protein. (202 aa)
	GAREM2	GRB2 associated regulator of MAPK1 subtype 2. (634 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (486 aa)
	DENND5A	DENN domain containing 5A. (1192 aa)
	ENSSBOP00000006230	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (216 aa)
	ENSSBOP00000004844	Uncharacterized protein. (129 aa)
	RAB9A	RAB9A, member RAS oncogene family. (201 aa)
	TRAPPC10	Uncharacterized protein. (1249 aa)
	RAB39A	RAB39A, member RAS oncogene family. (217 aa)
	RAB7B	RAB7B, member RAS oncogene family. (199 aa)
	DENND3	DENN domain containing 3. (1249 aa)

Your Current Organism:

Saimiri boliviensis

NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSSBOP00000006552	ENSSBOP00000038751	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.971
AKT1	AKT3	ENSSBOP00000006552	ENSSBOP00000026533	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.937
AKT2	AKT1	ENSSBOP00000038751	ENSSBOP00000006552	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.971
AKT2	AKT3	ENSSBOP00000038751	ENSSBOP00000026533	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.938
AKT3	AKT1	ENSSBOP00000026533	ENSSBOP00000006552	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.937
AKT3	AKT2	ENSSBOP00000026533	ENSSBOP00000038751	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.938
ALS2	ALS2CL	ENSSBOP00000019054	ENSSBOP00000039215	Alsin Rho guanine nucleotide exchange factor ALS2.	ALS2 C-terminal like.	0.457
ALS2	ANKRD27	ENSSBOP00000019054	ENSSBOP00000000830	Alsin Rho guanine nucleotide exchange factor ALS2.	Ankyrin repeat domain 27.	0.570
ALS2	ENSSBOP00000018573	ENSSBOP00000019054	ENSSBOP00000018573	Alsin Rho guanine nucleotide exchange factor ALS2.	Uncharacterized protein.	0.418
ALS2	ENSSBOP00000038478	ENSSBOP00000019054	ENSSBOP00000038478	Alsin Rho guanine nucleotide exchange factor ALS2.	Uncharacterized protein.	0.487
ALS2	GAPVD1	ENSSBOP00000019054	ENSSBOP00000022657	Alsin Rho guanine nucleotide exchange factor ALS2.	GTPase activating protein and VPS9 domains 1.	0.738
ALS2	GDI1	ENSSBOP00000019054	ENSSBOP00000008729	Alsin Rho guanine nucleotide exchange factor ALS2.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.580
ALS2	GDI2	ENSSBOP00000019054	ENSSBOP00000018941	Alsin Rho guanine nucleotide exchange factor ALS2.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.580
ALS2	RAB31	ENSSBOP00000019054	ENSSBOP00000016051	Alsin Rho guanine nucleotide exchange factor ALS2.	RAB31, member RAS oncogene family.	0.418
ALS2	RAB5A	ENSSBOP00000019054	ENSSBOP00000025038	Alsin Rho guanine nucleotide exchange factor ALS2.	RAB5A, member RAS oncogene family.	0.487
ALS2	RAB5B	ENSSBOP00000019054	ENSSBOP00000038710	Alsin Rho guanine nucleotide exchange factor ALS2.	RAB5B, member RAS oncogene family.	0.501
ALS2	RAB5C	ENSSBOP00000019054	ENSSBOP00000032743	Alsin Rho guanine nucleotide exchange factor ALS2.	Uncharacterized protein.	0.487
ALS2	RABGEF1	ENSSBOP00000019054	ENSSBOP00000015507	Alsin Rho guanine nucleotide exchange factor ALS2.	Uncharacterized protein.	0.957
ALS2	RIN1	ENSSBOP00000019054	ENSSBOP00000037332	Alsin Rho guanine nucleotide exchange factor ALS2.	Ras and Rab interactor 1.	0.531
ALS2	RIN2	ENSSBOP00000019054	ENSSBOP00000024670	Alsin Rho guanine nucleotide exchange factor ALS2.	Ras and Rab interactor 2.	0.469