46 items (Saimiri boliviensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PAK4	Non-specific serine/threonine protein kinase. (594 aa)
	ENSSBOP00000002754	Uncharacterized protein. (147 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (780 aa)
	ENSSBOP00000003434	Uncharacterized protein. (147 aa)
	DEPDC1B	DEP domain containing 1B. (529 aa)
	HGS	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (692 aa)
	WWP2	E3 ubiquitin-protein ligase. (870 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
	PEAK1	Pseudopodium enriched atypical kinase 1. (1747 aa)
	RHOU	Ras homolog family member U. (276 aa)
	PAK3	P21 (RAC1) activated kinase 3. (580 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1673 aa)
	ARHGAP30	Rho GTPase activating protein 30. (1105 aa)
	CDC42	Uncharacterized protein. (191 aa)
	STAM	Signal transducing adaptor molecule. (541 aa)
	STAM2	Uncharacterized protein. (525 aa)
	DST	Dystonin. (7439 aa)
	SPTAN1	Spectrin alpha, non-erythrocytic 1. (2409 aa)
	SPTBN1	Spectrin beta chain; Belongs to the spectrin family. (2364 aa)
	ENSSBOP00000022506	Uncharacterized protein. (442 aa)
	ARHGAP31	Rho GTPase activating protein 31. (1444 aa)
	TXNL1	Thioredoxin like 1. (317 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1294 aa)
	EPHA2	EPH receptor A2. (965 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	SRGAP2	Uncharacterized protein. (1071 aa)
	GIT1	GIT ArfGAP 1. (766 aa)
	GIT2	GIT ArfGAP 2. (686 aa)
	PEAK3	PEAK family member 3. (353 aa)
	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
	USP9X	Ubiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa)
	PARD6A	Par-6 family cell polarity regulator alpha. (385 aa)
	VANGL1	Vang-like protein. (524 aa)
	GRB2	Growth factor receptor bound protein 2. (184 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	WDR6	WD repeat domain 6. (1121 aa)
	PAK2	Non-specific serine/threonine protein kinase. (525 aa)
	ITSN2	Intersectin 2. (1688 aa)
	PIK3R2	Uncharacterized protein. (674 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
	PAK1	Non-specific serine/threonine protein kinase. (555 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1902 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (727 aa)
	MACF1	Microtubule actin crosslinking factor 1. (7598 aa)
	ENSSBOP00000040512	Uncharacterized protein. (158 aa)

Your Current Organism:

Saimiri boliviensis

NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP30	ITSN2	ENSSBOP00000016012	ENSSBOP00000036126	Rho GTPase activating protein 30.	Intersectin 2.	0.764
ARHGAP30	RHOU	ENSSBOP00000016012	ENSSBOP00000008566	Rho GTPase activating protein 30.	Ras homolog family member U.	0.584
ARHGAP31	CDC42	ENSSBOP00000022734	ENSSBOP00000018173	Rho GTPase activating protein 31.	Uncharacterized protein.	0.416
ARHGAP31	ENSSBOP00000002754	ENSSBOP00000022734	ENSSBOP00000002754	Rho GTPase activating protein 31.	Uncharacterized protein.	0.416
ARHGAP31	ENSSBOP00000003434	ENSSBOP00000022734	ENSSBOP00000003434	Rho GTPase activating protein 31.	Uncharacterized protein.	0.416
ARHGAP31	ENSSBOP00000040512	ENSSBOP00000022734	ENSSBOP00000040512	Rho GTPase activating protein 31.	Uncharacterized protein.	0.416
ARHGAP31	ITSN2	ENSSBOP00000022734	ENSSBOP00000036126	Rho GTPase activating protein 31.	Intersectin 2.	0.766
ARHGAP31	RHOU	ENSSBOP00000022734	ENSSBOP00000008566	Rho GTPase activating protein 31.	Ras homolog family member U.	0.535
ARHGEF6	ARHGEF7	ENSSBOP00000030444	ENSSBOP00000002832	Rac/Cdc42 guanine nucleotide exchange factor 6.	Rho guanine nucleotide exchange factor 7.	0.968
ARHGEF6	CDC42	ENSSBOP00000030444	ENSSBOP00000018173	Rac/Cdc42 guanine nucleotide exchange factor 6.	Uncharacterized protein.	0.650
ARHGEF6	ENSSBOP00000002754	ENSSBOP00000030444	ENSSBOP00000002754	Rac/Cdc42 guanine nucleotide exchange factor 6.	Uncharacterized protein.	0.650
ARHGEF6	ENSSBOP00000003434	ENSSBOP00000030444	ENSSBOP00000003434	Rac/Cdc42 guanine nucleotide exchange factor 6.	Uncharacterized protein.	0.650
ARHGEF6	ENSSBOP00000040512	ENSSBOP00000030444	ENSSBOP00000040512	Rac/Cdc42 guanine nucleotide exchange factor 6.	Uncharacterized protein.	0.650
ARHGEF6	GIT1	ENSSBOP00000030444	ENSSBOP00000027754	Rac/Cdc42 guanine nucleotide exchange factor 6.	GIT ArfGAP 1.	0.991
ARHGEF6	GIT2	ENSSBOP00000030444	ENSSBOP00000029171	Rac/Cdc42 guanine nucleotide exchange factor 6.	GIT ArfGAP 2.	0.922
ARHGEF6	GRB2	ENSSBOP00000030444	ENSSBOP00000034988	Rac/Cdc42 guanine nucleotide exchange factor 6.	Growth factor receptor bound protein 2.	0.571
ARHGEF6	HGS	ENSSBOP00000030444	ENSSBOP00000004238	Rac/Cdc42 guanine nucleotide exchange factor 6.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.412
ARHGEF6	ITSN2	ENSSBOP00000030444	ENSSBOP00000036126	Rac/Cdc42 guanine nucleotide exchange factor 6.	Intersectin 2.	0.943
ARHGEF6	NCK1	ENSSBOP00000030444	ENSSBOP00000035290	Rac/Cdc42 guanine nucleotide exchange factor 6.	Cytoplasmic protein.	0.744
ARHGEF6	NCK2	ENSSBOP00000030444	ENSSBOP00000010139	Rac/Cdc42 guanine nucleotide exchange factor 6.	Cytoplasmic protein.	0.643