(17 nodes) (2022) Sleep timing and the circadian clock in mammals: Past, present and the road ahead. network (Saimiri boliviensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CRY1	Photolyase/cryptochrome alpha/beta domain-containing protein. (594 aa)
	GAL	Galanin and GMAP prepropeptide. (123 aa)
	HCRT	Orexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (130 aa)
	TIMELESS	Timeless circadian regulator. (1204 aa)
	SST	Somatostatin. (116 aa)
	NPY	Neuropeptide Y. (97 aa)
	PER3	Period circadian regulator 3. (1190 aa)
	SYT10	Synaptotagmin 10. (523 aa)
	GRP	Gastrin releasing peptide. (147 aa)
	NMS	Neuromedin S. (153 aa)
	CRY2	Cryptochrome circadian regulator 2. (593 aa)
	PROK2	Prokineticin 2. (129 aa)
	CLOCK	Clock circadian regulator. (845 aa)
	NPAS2	Neuronal PAS domain protein 2. (824 aa)
	NTS	Neurotensin. (170 aa)
	CCK	Cholecystokinin. (115 aa)
	PER2	Period circadian regulator 2. (1249 aa)

Your Current Organism:

Saimiri boliviensis

NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCK	GAL	ENSSBOP00000033918	ENSSBOP00000004647	Cholecystokinin.	Galanin and GMAP prepropeptide.	0.763
CCK	GRP	ENSSBOP00000033918	ENSSBOP00000023234	Cholecystokinin.	Gastrin releasing peptide.	0.792
CCK	HCRT	ENSSBOP00000033918	ENSSBOP00000004770	Cholecystokinin.	Orexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family.	0.645
CCK	NPY	ENSSBOP00000033918	ENSSBOP00000014247	Cholecystokinin.	Neuropeptide Y.	0.901
CCK	NTS	ENSSBOP00000033918	ENSSBOP00000032851	Cholecystokinin.	Neurotensin.	0.859
CCK	PROK2	ENSSBOP00000033918	ENSSBOP00000026815	Cholecystokinin.	Prokineticin 2.	0.455
CCK	SST	ENSSBOP00000033918	ENSSBOP00000012802	Cholecystokinin.	Somatostatin.	0.926
CLOCK	CRY1	ENSSBOP00000028622	ENSSBOP00000018535	Clock circadian regulator.	Photolyase/cryptochrome alpha/beta domain-containing protein.	0.994
CLOCK	CRY2	ENSSBOP00000028622	ENSSBOP00000024526	Clock circadian regulator.	Cryptochrome circadian regulator 2.	0.995
CLOCK	NPAS2	ENSSBOP00000028622	ENSSBOP00000032243	Clock circadian regulator.	Neuronal PAS domain protein 2.	0.977
CLOCK	PER2	ENSSBOP00000028622	ENSSBOP00000034348	Clock circadian regulator.	Period circadian regulator 2.	0.987
CLOCK	PER3	ENSSBOP00000028622	ENSSBOP00000014884	Clock circadian regulator.	Period circadian regulator 3.	0.853
CLOCK	TIMELESS	ENSSBOP00000028622	ENSSBOP00000008172	Clock circadian regulator.	Timeless circadian regulator.	0.741
CRY1	CLOCK	ENSSBOP00000018535	ENSSBOP00000028622	Photolyase/cryptochrome alpha/beta domain-containing protein.	Clock circadian regulator.	0.994
CRY1	CRY2	ENSSBOP00000018535	ENSSBOP00000024526	Photolyase/cryptochrome alpha/beta domain-containing protein.	Cryptochrome circadian regulator 2.	0.989
CRY1	GRP	ENSSBOP00000018535	ENSSBOP00000023234	Photolyase/cryptochrome alpha/beta domain-containing protein.	Gastrin releasing peptide.	0.437
CRY1	NPAS2	ENSSBOP00000018535	ENSSBOP00000032243	Photolyase/cryptochrome alpha/beta domain-containing protein.	Neuronal PAS domain protein 2.	0.991
CRY1	NTS	ENSSBOP00000018535	ENSSBOP00000032851	Photolyase/cryptochrome alpha/beta domain-containing protein.	Neurotensin.	0.437
CRY1	PER2	ENSSBOP00000018535	ENSSBOP00000034348	Photolyase/cryptochrome alpha/beta domain-containing protein.	Period circadian regulator 2.	0.996
CRY1	PER3	ENSSBOP00000018535	ENSSBOP00000014884	Photolyase/cryptochrome alpha/beta domain-containing protein.	Period circadian regulator 3.	0.979