(20 nodes) (2021) Unraveling Human Brain Development and Evolution Using Organoid Models. network (Saimiri boliviensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	MBP	Myelin basic protein. (304 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	TBR1	T-box brain transcription factor 1. (682 aa)
	LHX5	LIM homeobox 5. (402 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	SSTR2	Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (506 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (552 aa)
	CNP	2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (421 aa)
	INSR	Tyrosine-protein kinase receptor. (1388 aa)
	FEZF1	FEZ family zinc finger 1. (475 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	TH	Tyrosine hydroxylase. (528 aa)
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (330 aa)
	ORC4	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
	ITGB8	Integrin beta; Belongs to the integrin beta chain family. (770 aa)
	SATB2	DNA-binding protein SATB. (733 aa)
	RPS6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
	PAX6	Paired box 6. (488 aa)

Your Current Organism:

Saimiri boliviensis

NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	FGF2	ENSSBOP00000022210	ENSSBOP00000028462	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.680
BDNF	GFAP	ENSSBOP00000022210	ENSSBOP00000007664	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.654
BDNF	INSR	ENSSBOP00000022210	ENSSBOP00000013498	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine-protein kinase receptor.	0.749
BDNF	MBP	ENSSBOP00000022210	ENSSBOP00000028745	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Myelin basic protein.	0.585
BDNF	TH	ENSSBOP00000022210	ENSSBOP00000019737	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine hydroxylase.	0.747
CNP	FEZF1	ENSSBOP00000012311	ENSSBOP00000015521	2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family.	FEZ family zinc finger 1.	0.461
CNP	GFAP	ENSSBOP00000012311	ENSSBOP00000007664	2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.664
CNP	LHX5	ENSSBOP00000012311	ENSSBOP00000026894	2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family.	LIM homeobox 5.	0.474
CNP	MBP	ENSSBOP00000012311	ENSSBOP00000028745	2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family.	Myelin basic protein.	0.807
CNP	ORC4	ENSSBOP00000012311	ENSSBOP00000023185	2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family.	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.	0.572
CNP	SSTR2	ENSSBOP00000012311	ENSSBOP00000004907	2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family.	Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.471
FEZF1	CNP	ENSSBOP00000015521	ENSSBOP00000012311	FEZ family zinc finger 1.	2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family.	0.461
FEZF1	LHX5	ENSSBOP00000015521	ENSSBOP00000026894	FEZ family zinc finger 1.	LIM homeobox 5.	0.657
FEZF1	ORC4	ENSSBOP00000015521	ENSSBOP00000023185	FEZ family zinc finger 1.	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.	0.416
FEZF1	PAX6	ENSSBOP00000015521	ENSSBOP00000001518	FEZ family zinc finger 1.	Paired box 6.	0.481
FEZF1	SATB2	ENSSBOP00000015521	ENSSBOP00000024442	FEZ family zinc finger 1.	DNA-binding protein SATB.	0.496
FEZF1	SSTR2	ENSSBOP00000015521	ENSSBOP00000004907	FEZ family zinc finger 1.	Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.419
FEZF1	TBR1	ENSSBOP00000015521	ENSSBOP00000027098	FEZ family zinc finger 1.	T-box brain transcription factor 1.	0.531
FGF2	BDNF	ENSSBOP00000028462	ENSSBOP00000022210	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.680
FGF2	GFAP	ENSSBOP00000028462	ENSSBOP00000007664	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.506