STRINGSTRING
CERS1 CERS1 DEGS2 DEGS2 MS4A2 MS4A2 SPHK1 SPHK1 RAC3 RAC3 ADORA1 ADORA1 SGPP2 SGPP2 RAF1 RAF1 ENSSBOP00000003528 ENSSBOP00000003528 S1PR2 S1PR2 S1PR3 S1PR3 NOS3 NOS3 MAPK9 MAPK9 PIK3CA PIK3CA S1PR1 S1PR1 AKT1 AKT1 CTSD CTSD TNF TNF PLD2 PLD2 PIK3CB PIK3CB GAB2 GAB2 NRAS NRAS MAPK12 MAPK12 GNA12 GNA12 PPP2R2D PPP2R2D RAC2 RAC2 GNAQ GNAQ PPP2R3C PPP2R3C PRKCG PRKCG PPP2R2A PPP2R2A KRAS KRAS PPP2R3A PPP2R3A PRKCE PRKCE BDKRB2 BDKRB2 MAP2K1 MAP2K1 HRAS HRAS CERS4 CERS4 PLCB1 PLCB1 SGMS1 SGMS1 PDPK1 PDPK1 CERS3 CERS3 RAC1 RAC1 PLD1 PLD1 PIK3R3 PIK3R3 BID BID SGMS2 SGMS2 NSMAF NSMAF PRKCZ PRKCZ SMPD1 SMPD1 ROCK2 ROCK2 PPP2R5C PPP2R5C KNG1 KNG1 CERS6 CERS6 SPTLC1 SPTLC1 NFKB1 NFKB1 MAPK14 MAPK14 ACER1 ACER1 RHOC RHOC TRAF2 TRAF2 GNAI2 GNAI2 MAPK1 MAPK1 PRKCB PRKCB SPTLC3 SPTLC3 FCER1A FCER1A PPP2R2B PPP2R2B MAPK10 MAPK10 SPTLC2 SPTLC2 PTEN PTEN PLCB4 PLCB4 AKT3 AKT3 TNFRSF1A TNFRSF1A GNAI1 GNAI1 MAPK3 MAPK3 PPP2R1A PPP2R1A ASAH1 ASAH1 TRADD TRADD DEGS1 DEGS1 PPP2R5A PPP2R5A SGPL1 SGPL1 PPP2CB PPP2CB PLCB2 PLCB2 SPHK2 SPHK2 ASAH2 ASAH2 FYN FYN MAP3K5 MAP3K5 GNA13 GNA13 ACER2 ACER2 PPP2R5D PPP2R5D CERS2 CERS2 FCER1G FCER1G MAP2K2 MAP2K2 PPP2R2C PPP2R2C SMPD2 SMPD2 PIK3R2 PIK3R2 PPP2R1B PPP2R1B ABCC1 ABCC1 MAPK13 MAPK13 ROCK1 ROCK1 PRKCA PRKCA MAPK8 MAPK8 MAPK11 MAPK11 PLCB3 PLCB3 AKT2 AKT2 RELA RELA PPP2R5E PPP2R5E PIK3R1 PIK3R1 PPP2R5B PPP2R5B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CERS1TLC domain-containing protein. (239 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (323 aa)
MS4A2Uncharacterized protein. (139 aa)
SPHK1Sphingosine kinase 1. (488 aa)
RAC3Rac family small GTPase 3. (311 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (353 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ENSSBOP00000003528Uncharacterized protein. (1061 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (379 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (486 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (389 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
PLD2Phospholipase. (933 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1091 aa)
GAB2GRB2 associated binding protein 2. (638 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
GNA12G protein subunit alpha 12. (318 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (445 aa)
RAC2Rac family small GTPase 2. (192 aa)
GNAQG protein subunit alpha q. (301 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (698 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1119 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (389 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CERS4Ceramide synthase 4. (400 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
SGMS1Sphingomyelin synthase 1. (413 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (555 aa)
CERS3Ceramide synthase 3. (382 aa)
RAC1Uncharacterized protein. (207 aa)
PLD1Phospholipase. (1074 aa)
PIK3R3Uncharacterized protein. (461 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (192 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
NSMAFNeutral sphingomyelinase activation associated factor. (911 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (587 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1386 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
KNG1Kininogen 1. (644 aa)
CERS6Ceramide synthase 6. (375 aa)
SPTLC1Aminotran_1_2 domain-containing protein. (498 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
RHOCUncharacterized protein. (100 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (526 aa)
GNAI2G protein subunit alpha i2. (355 aa)
MAPK1Mitogen-activated protein kinase 1. (305 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (553 aa)
FCER1AFc fragment of IgE receptor Ia. (257 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
MAPK10Mitogen-activated protein kinase. (541 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (497 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
GNAI1G protein subunit alpha i1. (311 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (432 aa)
TRADDTNFRSF1A associated via death domain. (252 aa)
DEGS1Delta 4-desaturase, sphingolipid 1. (323 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
SPHK2Sphingosine kinase 2. (656 aa)
ASAH2Neutral ceramidase. (778 aa)
FYNTyrosine-protein kinase. (537 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1354 aa)
GNA13G protein subunit alpha 13. (282 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (666 aa)
CERS2Ceramide synthase 2. (431 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (369 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (422 aa)
PIK3R2Uncharacterized protein. (674 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (695 aa)
ABCC1ATP binding cassette subfamily C member 1. (1520 aa)
MAPK13Mitogen-activated protein kinase. (450 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAPK11Mitogen-activated protein kinase. (372 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1229 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RELARELA proto-oncogene, NF-kB subunit. (520 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (472 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (727 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
Your Current Organism:
Saimiri boliviensis
NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis
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